| Tag | Content |
|---|---|
| UniProt Accession | AMOT_HUMAN; Q4VCS5; |
| Entrez ID | 154796 |
| GenBank Protein ID | NM_001113490.1; NM_133265.2; XM_005262087.1; XM_005262090.1; XM_011530875.2; XM_017029289.1; |
| GenBank Nucleotide ID | NP_001106962.1; NP_573572.1; XP_005262144.1; XP_005262147.1; XP_011529177.1; XP_016884778.1; |
| Protein Name | Angiomotin |
| Gene Name | AMOT; KIAA1071 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. |
| Sequence (Fasta) | MRNSEEQPSG GTTVLQRLLQ EQLRYGNPSE NRSLLAIHQQ ATGNGPPFPS GSGNPGPQSD 60 VLSPQDHHQQ LVAHAARQEP QGQEIQSENL IMEKQLSPRM QNNEELPTYE EAKVQSQYFR 120 GQQHASVGAA FYVTGVTNQK MRTEGRPSVQ RLNPGKMHQD EGLRDLKQGH VRSLSERLMQ 180 MSLATSGVKA HPPVTSAPLS PPQPNDLYKN PTSSSEFYKA QGPLPNQHSL KGMEHRGPPP 240 EYPFKGMPPQ SVVCKPQEPG HFYSEHRLNQ PGRTEGQLMR YQHPPEYGAA RPAQDISLPL 300 SARNSQPHSP TSSLTSGGSL PLLQSPPSTR LSPARHPLVP NQGDHSAHLP RPQQHFLPNQ 360 AHQGDHYRLS QPGLSQQQQQ QQQQHHHHHH HQQQQQQQPQ QQPGEAYSAM PRAQPSSASY 420 QPVPADPFAI VSRAQQMVEI LSDENRNLRQ ELEGCYEKVA RLQKVETEIQ RVSEAYENLV 480 KSSSKREALE KAMRNKLEGE IRRMHDFNRD LRERLETANK QLAEKEYEGS EDTRKTISQL 540 FAKNKESQRE KEKLEAELAT ARSTNEDQRR HIEIRDQALS NAQAKVVKLE EELKKKQVYV 600 DKVEKMQQAL VQLQAACEKR EQLEHRLRTR LERELESLRI QQRQGNCQPT NVSEYNAAAL 660 MELLREKEER ILALEADMTK WEQKYLEENV MRHFALDAAA TVAAQRDTTV ISHSPNTSYD 720 TALEARIQKE EEEILMANKR CLDMEGRIKT LHAQIIEKDA MIKVLQQRSR KEPSKTEQLS 780 CMRPAKSLMS ISNAGSGLLS HSSTLTGSPI MEEKRDDKSW KGSLGILLGG DYRAEYVPST 840 PSPVPPSTPL LSAHSKTGSR DCSTQTERGT ESNKTAAVAP ISVPAPVAAA ATAAAITATA 900 ATITTTMVAA APVAVAAAAA PAAAAAPSPA TAAATAAAVS PAAAGQIPAA ASVASAAAVA 960 PSAAAAAAVQ VAPAAPAPVP APALVPVPAP AAAQASAPAQ TQAPTSAPAV APTPAPTPTP 1020 AVAQAEVPAS PATGPGPHRL SIPSLTCNPD KTDGPVFHSN TLERKTPIQI LGQEPDAEMV 1080 EYLI 1085 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 1) | rs2189809; Urinary metabolites; kidney disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 33) (view all) | 1059 TDGPVFHSNTLERKT dbPAF
1061 GPVFHSNTLERKTPI dbPAF 109 NNEELPTYEEAKVQS dbPAF 12 EEQPSGGTTVLQRLL dbPAF 175 QGHVRSLSERLMQMS dbPAF 200 PVTSAPLSPPQPNDL dbPAF |
| Acetylation (count: 1) | 545 SQLFAKNKESQREKE PLMD |
| Ubiquitination (count: 9) (view all) | 113 LPTYEEAKVQSQYFR PLMD
167 DEGLRDLKQGHVRSL PLMD 209 PQPNDLYKNPTSSSE PLMD 219 TSSSEFYKAQGPLPN PLMD 464 EKVARLQKVETEIQR PLMD 496 LEKAMRNKLEGEIRR PLMD |
| Sumoylation (count: 1) | 594 VKLEEELKKKQVYVD PLMD |
| Glycation (count: 1) | 763 IEKDAMIKVLQQRSR PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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