Q2NL51

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	GSK3A_MOUSE; Q2NL51;
Entrez ID	606496
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
Gene Name	Gsk3a
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in m(view all) Functional Description Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Sequence (Fasta)	MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV 60 GASSSGGGPS GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATVGQG PERSQEVAYT 120 DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 180 SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLITPIIY IKVYMYQLFR SLAYIHSQGV 240 CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 300 IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK 360 AHPWTKVFKS SKTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFFDELRRL GAQLPNDRPL 420 PPLFNFSPGE LSIQPSLNAI LIPPHLRSPA GPASPLTTSY NPSSQALTEA QTGQDWQPSD 480 ATTATLASSS 491 Fasta Sequence >Q2NL51\|Gsk3a\|Mus musculus (Mouse) MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAGPASPLTTSYNPSSQALTEAQTGQDWQPSDATTATLASSS

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Alzheimer's disease		D	S21	15033922
1	[Reference]: Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.
2	Serine Phosphorylation	Diabetes mellitus		D	S21	15033922; 17130464
2	[Reference]: Most interestingly, we found that decreased pS21-GSK-3alpha and pS9-GSK-3beta phosphorylation, which is an index of GSK activation, positively correlated with the generation of brain C-terminal fragment (CTF)-gamma cleavage product of amyloid precursor protein

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:D001714 ; Bipolar Disorder MESH:D003866 ; Depressive Disorder MESH:D012559 ; Schizophrenia

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 18) (view all)	14 SGGGPGGSGRARTSS dbPAF 19 GGSGRARTSSFAEPG dbPAF 2 ****MSGGGPSGG dbPAF 20 GSGRARTSSFAEPGG dbPAF 21 SGRARTSSFAEPGGG dbPAF 278 VRGEPNVSYICSRYY dbPAF 279 RGEPNVSYICSRYYR dbPAF 282 PNVSYICSRYYRAPE dbPAF 39 GGGGPGGSASGPGGT dbPAF 41 GGPGGSASGPGGTGG dbPAF 454 RSPAGPASPLTTSYN dbPAF 488 ATTATLASSS*** dbPAF 7 *MSGGGPSGGGPGGS dbPAF 70 SSSGGGPSGSGGGGS dbPAF 72 SGGGPSGSGGGGSGG dbPAF 77 SGSGGGGSGGPGAGT dbPAF 84 SGGPGAGTSFPPPGV dbPAF 85 GGPGAGTSFPPPGVK dbPAF
Acetylation (count: 1)	166 RELQIMRKLDHCNIV PLMD
Ubiquitination (count: 3)	268 LCDFGSAKQLVRGEP PLMD 355 NPNYTEFKFPQIKAH PLMD 372 TKVFKSSKTPPEAIA PLMD