Q16881

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TRXR1_HUMAN; Q16881;
Entrez ID 7296
GenBank Protein ID NM_001093771.2; NM_001261445.1; NM_001261446.1; NM_003330.3; NM_182729.2; NM_182742.2; NM_182743.2;
GenBank Nucleotide ID NP_001087240.1; NP_001248374.1; NP_001248375.1; NP_003321.3; NP_877393.1; NP_877419.1; NP_877420.1;
Protein Name Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thior
Gene Name TXNRD1; GRIM12; KDRF
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionIsoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Sequence
(Fasta)		MGCAEGKAVA AAAPTELQTK GKNGDGRRRS AKDHHPGKTL PENPAGFTST ATADSRALLQ 60
AYIDGHSVVI FSRSTCTRCT EVKKLFKSLC VPYFVLELDQ TEDGRALEGT LSELAAETDL 120
PVVFVKQRKI GGHGPTLKAY QEGRLQKLLK MNGPEDLPKS YDYDLIIIGG GSGGLAAAKE 180
AAQYGKKVMV LDFVTPTPLG TRWGLGGTCV NVGCIPKKLM HQAALLGQAL QDSRNYGWKV 240
EETVKHDWDR MIEAVQNHIG SLNWGYRVAL REKKVVYENA YGQFIGPHRI KATNNKGKEK 300
IYSAERFLIA TGERPRYLGI PGDKEYCISS DDLFSLPYCP GKTLVVGASY VALECAGFLA 360
GIGLDVTVMV RSILLRGFDQ DMANKIGEHM EEHGIKFIRQ FVPIKVEQIE AGTPGRLRVV 420
AQSTNSEEII EGEYNTVMLA IGRDACTRKI GLETVGVKIN EKTGKIPVTD EEQTNVPYIY 480
AIGDILEDKV ELTPVAIQAG RLLAQRLYAG STVKCDYENV PTTVFTPLEY GACGLSEEKA 540
VEKFGEENIE VYHSYFWPLE WTIPSRDNNK CYAKIICNTK DNERVVGFHV LGPNAGEVTQ 600
GFAAALKCGL TKKQLDSTIG IHPVCAEVFT TLSVTKRSGA SILQAGCUG

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNeuroblastomaUY28124349301
[Reference]: Increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line)

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 8)
(view all)		MESH:D000236 ; Adenoma
MESH:D018827 ; Carcinoma, Lewis Lung
MESH:D015179 ; Colorectal Neoplasms
MESH:D003877 ; Dermatitis, Contact
MESH:D004827 ; Epilepsy
MESH:D008654 ; Mesothelioma
GWASdb
(count: 5)		rs4545635; Alzheimer's disease; Alzheimer's disease
rs4964735; Type 2 diabetes; type 2 diabetes mellitus
rs10861184; Alcohol dependence; alcohol dependence
rs10735392; Urinary metabolites; kidney disease
rs10861197; Glucose levels; type 2 diabetes mellitus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 160       GPEDLPKSYDYDLII     dbPAF
161       PEDLPKSYDYDLIII     dbPAF
163       DLPKSYDYDLIIIGG     dbPAF
184       AAKEAAQYGKKVMVL     dbPAF
201       VTPTPLGTRWGLGGT     dbPAF
277       LREKKVVYENAYGQF     dbPAF
Acetylation
(count: 13)
(view all)		 179       SGGLAAAKEAAQYGK     PLMD
217       VNVGCIPKKLMHQAA     PLMD
239       DSRNYGWKVEETVKH     PLMD
245       WKVEETVKHDWDRMI     PLMD
274       RVALREKKVVYENAY     PLMD
300       TNNKGKEKIYSAERF     PLMD
Ubiquitination
(count: 25)
(view all)		 126       DLPVVFVKQRKIGGH     PLMD
179       SGGLAAAKEAAQYGK     PLMD
187       EAAQYGKKVMVLDFV     PLMD
217       VNVGCIPKKLMHQAA     PLMD
218       NVGCIPKKLMHQAAL     PLMD
239       DSRNYGWKVEETVKH     PLMD
Sumoylation
(count: 1)		 405       IRQFVPIKVEQIEAG     PLMD
Malonylation
(count: 3)		 274       RVALREKKVVYENAY     PLMD
300       TNNKGKEKIYSAERF     PLMD
449       GRDACTRKIGLETVG     PLMD
Succinylation
(count: 2)		 245       WKVEETVKHDWDRMI     PLMD
405       IRQFVPIKVEQIEAG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource