Q16875

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession F263_HUMAN; Q16875;
Entrez ID 5209
GenBank Protein ID NM_001282630.2; NM_001314063.1; NM_004566.3;
GenBank Nucleotide ID NP_001269559.1; NP_001300992.1; NP_004557.1;
Protein Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2
Gene Name PFKFB3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionSynthesis and degradation of fructose 2,6-bisphosphate.
Sequence
(Fasta)		MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN 60
WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMKVRK QCALAALRDV KSYLAKEGGQ 120
IAVFDATNTT RERRHMILHF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS 180
AEAMDDFMKR ISCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM 240
NIHVQPRTIY LCRHGENEHN LQGRIGGDSG LSSRGKKFAS ALSKFVEEQN LKDLRVWTSQ 300
LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG 360
ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL 420
TPVAYGCRVE SIYLNVESVC THRERSEDAK KGPNPLMRRN SVTPLASPEP TKKPRINSFE 480
EHVASTSAAL PSCLPPEVPT QLPGQNMKGS RSSADSSRKH 521

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Arginine MethylationColon cancer/carcinomaHCT116 cell linePR13124633012
[Reference]: CO decreases methylated PFKFB3 to cause chemoresistance
2Arginine MethylationColon cancer/carcinomaHCT116 cell linePR13424633012
[Reference]: CO decreases methylated PFKFB3 to cause chemoresistance

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D020261 ; Arsenic Poisoning
MESH:D017202 ; Myocardial Ischemia
MESH:D009765 ; Obesity
MESH:D012871 ; Skin Diseases
GWASdb
(count: 7)
(view all)		rs11257010; Multiple complex diseases; Null
rs674430; Non-alcoholic fatty liver disease histology (other); fatty liver disease
rs678395; Multiple complex diseases; Null
rs2516618; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension
rs2148294; Aging (time to event); Null
rs1064891; Celiac disease; celiac disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 11)
(view all)		 172       IMEVKISSPDYKDCN     dbPAF
194       FMKRISCYEASYQPL     dbPAF
273       GGDSGLSSRGKKFAS     dbPAF
283       KKFASALSKFVEEQN     dbPAF
403       LAYFLDKSAEEMPYL     dbPAF
461       NPLMRRNSVTPLASP     dbPAF
Acetylation
(count: 1)		 411       AEEMPYLKCPLHTVL     PLMD
Ubiquitination
(count: 8)
(view all)		 111       LAALRDVKSYLAKEG     PLMD
116       DVKSYLAKEGGQIAV     PLMD
214       DRDLSLIKVIDVGRR     PLMD
292       FVEEQNLKDLRVWTS     PLMD
302       RVWTSQLKSTIQTAE     PLMD
352       YALREQDKYYYRYPT     PLMD
Malonylation
(count: 1)		 100       EEAMKVRKQCALAAL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource