Q16658

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession FSCN1_HUMAN; Q16658;
Entrez ID 6624
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)
Gene Name FSCN1; FAN1; HSN; SNL
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionOrganizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
Sequence
(Fasta)		MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV 60
CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS 120
CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA 180
FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL 240
KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR 300
DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN 360
GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND 420
GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA 480
SAETVDPASL WEY 494

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationSquamous cell carcinomaUS3920713986
[Reference]: Our results suggest that high expression of fascin correlates with poor outcome and that high expression of phospho-S39-fascin decreases the risk of poor prognosis in ESCC.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs1640235; Hypertension (essential hypertension); hypertension

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 20)
(view all)		 115       HRRYFGGTEDRLSCF     dbPAF
120       GGTEDRLSCFAQTVS     dbPAF
127       SCFAQTVSPAEKWSV     dbPAF
145       MHPQVNIYSVTRKRY     dbPAF
146       HPQVNIYSVTRKRYA     dbPAF
148       QVNIYSVTRKRYAHL     dbPAF
Acetylation
(count: 10)
(view all)		 131       QTVSPAEKWSVHIAM     PLMD
241       SGPSGTLKAGKATKV     PLMD
250       GKATKVGKDELFALE     PLMD
303       LEIDRDTKKCAFRTH     PLMD
313       AFRTHTGKYWTLTAT     PLMD
353       TLRASNGKFVTSKKN     PLMD
Ubiquitination
(count: 14)
(view all)		 131       QTVSPAEKWSVHIAM     PLMD
241       SGPSGTLKAGKATKV     PLMD
247       LKAGKATKVGKDELF     PLMD
250       GKATKVGKDELFALE     PLMD
303       LEIDRDTKKCAFRTH     PLMD
353       TLRASNGKFVTSKKN     PLMD
Sumoylation
(count: 1)		 399       HGFIGCRKVTGTLDA     PLMD
Malonylation
(count: 4)		 220       TLEFRSGKVAFRDCE     PLMD
241       SGPSGTLKAGKATKV     PLMD
43        SASSLKKKQIWTLEQ     PLMD
74        GRYLAADKDGNVTCE     PLMD
Methylation
(count: 1)		 353       TLRASNGKFVTSKKN     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource