| Tag | Content |
|---|---|
| UniProt Accession | DREB_HUMAN; Q16643; |
| Entrez ID | 1627 |
| GenBank Protein ID | NM_004395.3; NM_080881.2; XM_005265827.3; XM_017009140.1; |
| GenBank Nucleotide ID | NP_004386.2; NP_543157.1; XP_005265884.1; XP_016864629.1; |
| Protein Name | Drebrin (Developmentally-regulated brain protein) |
| Gene Name | DBN1; D0S117E |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. |
| Sequence (Fasta) | MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG LQELSGHFEN 60 QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS HVAKVAEFFQ GVDVIVNASS 120 VEDIDAGAIG QRLSNGLARL SSPVLHRLRL REDENAEPVG TTYQKTDAAV EMKRINREQF 180 WEQAKKEEEL RKEEERKKAL DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ 240 TLEAEEAKRR LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV 300 ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE QIERALDEVT 360 SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP MEEPPQAQAP PRGPGSPAED 420 LMFMESAEQA VLAAPVEPAT ADATEIHDAA DTIETDTATA DTTVANNVPP AATSLIDLWP 480 GNGEGASTLQ GEPRAPTPPS GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP 540 ATFCDPEEVE GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ 600 SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD |
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| Database | Annotation |
|---|---|
| DisGeNet (Curated) (count: 2) | C0005586; Bipolar Disorder
C0036341; Schizophrenia |
| GWASdb (count: 9) (view all) | rs2544809; Dengue shock syndrome; dengue disease
rs2544809; End-stage coagulation; cerebrovascular disease|blood coagulation disease rs335466; End-stage coagulation; cerebrovascular disease|blood coagulation disease rs337374; End-stage coagulation; cerebrovascular disease|blood coagulation disease rs335467; End-stage coagulation; cerebrovascular disease|blood coagulation disease rs335468; End-stage coagulation; cerebrovascular disease|blood coagulation disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 43) (view all) | 134 GAIGQRLSNGLARLS dbPAF
141 SNGLARLSSPVLHRL dbPAF 142 NGLARLSSPVLHRLR dbPAF 162 NAEPVGTTYQKTDAA dbPAF 163 AEPVGTTYQKTDAAV dbPAF 241 EHRRKQQTLEAEEAK dbPAF |
| Acetylation (count: 7) (view all) | 165 PVGTTYQKTDAAVEM PLMD
173 TDAAVEMKRINREQF PLMD 252 EEAKRRLKEQSIFGD PLMD 295 DNPREFFKQQERVAS PLMD 62 SGHFENQKVMYGFCS PLMD 71 MYGFCSVKDSQAALP PLMD |
| Ubiquitination (count: 8) (view all) | 165 PVGTTYQKTDAAVEM PLMD
173 TDAAVEMKRINREQF PLMD 238 QIEEHRRKQQTLEAE PLMD 248 TLEAEEAKRRLKEQS PLMD 252 EEAKRRLKEQSIFGD PLMD 295 DNPREFFKQQERVAS PLMD |
| Malonylation (count: 1) | 295 DNPREFFKQQERVAS PLMD |
| Succinylation (count: 1) | 295 DNPREFFKQQERVAS PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |