Q16555

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	DPYL2_HUMAN; Q16555;
Entrez ID	1808
GenBank Protein ID	NM_001197293.2; NM_001244604.1; NM_001386.5;
GenBank Nucleotide ID	NP_001184222.1; NP_001231533.1; NP_001377.1;
Protein Name	Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)
Gene Name	DPYSL2; CRMP2; ULIP2
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. Functional Description Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Sequence (Fasta)	MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA 60 HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF 120 DQWREWADSK SCCDYSLHVD ISEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDCQ 180 IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRAI 240 TIANQTNCPL YITKVMSKSS AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA 300 FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE 360 RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR IAVGSDADLV IWDPDSVKTI 420 SAKTHNSSLE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK 480 RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS 540 LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG 573 Fasta Sequence >Q16555\|DPYSL2; CRMP2; ULIP2\|Homo sapiens (Human) MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Colon cancer/carcinoma		C		24036111
1	[Reference]: Using phosphorylation-mimetic and -resistant CRMP-2L constructs, it was revealed that phosphorylation of CRMP-2L negatively regulates its inhibitory function in ROCK-dependent haptotactic cell migration, as well as invasion of human colon carcinoma cells
2	Threonine Phosphorylation	Alzheimer's disease		U	T509	10757975
2	[Reference]: Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.
3	Threonine Phosphorylation	Non-small cell lung cancer/carcinoma	cell line	P	T514	23023514
3	[Reference]: Phosphorylated tubulin adaptor protein CRMP-2 as prognostic marker and candidate therapeutic target for NSCLC
4	Serine Phosphorylation	Alzheimer's disease		U	S518	10757975
4	[Reference]: Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.
5	Serine Phosphorylation	Non-small cell lung cancer/carcinoma		P	S522	26555036
5	[Reference]: in lung cancer the anti-phospho-Ser522 signal is positive in squamous cell carcinoma more frequently than adenocarcinoma.?
6	Serine Phosphorylation	Alzheimer's disease		U	S522	17683481; 10757975
6	[Reference]: Here, using novel phosphospecific antibodies, we demonstrate that phosphorylation of CRMP2 at Ser522 (Cdk5-mediated) is increased in Alzheimer?? disease (AD) brain,;

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:D000544 ; Alzheimer Disease MESH:D010003 ; Osteoarthritis MESH:D012563 ; Schizophrenia, Paranoid
DisGeNet (Curated) (count: 8) (view all)	C0001973; Alcoholic Intoxication, Chronic C0002395; Alzheimer's Disease C0005586; Bipolar Disorder C0011570; Mental Depression C0011581; Depressive disorder C0029408; Degenerative polyarthritis C0033937; Psychoses, Drug C0036349; Paranoid Schizophrenia
HGMD (count: 1)	CR035539; Schizophrenia, association with; Regulatory
GWASdb (count: 19) (view all)	rs7826601; Multiple complex diseases; Null rs7826601; Serum metabolites; Null rs431217; Hemoglobin; hemoglobinopathy rs431217; Erythrocyte counts; hematopoietic system disease\|heart disease rs327236; Adverse response to radiation therapy; rectal disease rs327234; Iron levels; iron metabolism disease rs327229; Height; Null rs327229; ldl cholesterol; atherosclerosis\|coronary artery disease rs13249543; Suicide attempts in bipolar disorder; bipolar disorder rs13249543; Post-operative nausea and vomiting; Null rs7832234; Multiple complex diseases; Null rs17055515; Multiple complex diseases; Null rs327224; Response to cytidine analogues (gemcitabine); cancer rs327227; Response to cytidine analogues (gemcitabine); cancer rs327215; Response to cytidine analogues (gemcitabine); cancer rs13271910; Multiple complex diseases; Null rs4733048; Suicide attempts in bipolar disorder; bipolar disorder rs4076071; Suicide attempts in bipolar disorder; bipolar disorder rs7828056; Type 2 diabetes; type 2 diabetes mellitus

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 29) (view all)	288 ASLGTDGSHYWSKNW dbPAF 3 ***MSYQGKKNIP dbPAF 30 KIVNDDQSFYADIYM dbPAF 32 VNDDQSFYADIYMED dbPAF 358 IPEGTNGTEERMSVI dbPAF 416 LVIWDPDSVKTISAK dbPAF 424 VKTISAKTHNSSLEY dbPAF 431 THNSSLEYNIFEGME dbPAF 462 EDGTLHVTEGSGRYI dbPAF 465 TLHVTEGSGRYIPRK dbPAF 479 KPFPDFVYKRIKARS dbPAF 499 RGVPRGLYDGPVCEV dbPAF 507 DGPVCEVSVTPKTVT dbPAF 509 PVCEVSVTPKTVTPA dbPAF 512 EVSVTPKTVTPASSA dbPAF 514 SVTPKTVTPASSAKT dbPAF 517 PKTVTPASSAKTSPA dbPAF 518 KTVTPASSAKTSPAK dbPAF 521 TPASSAKTSPAKQQA dbPAF 522 PASSAKTSPAKQQAP dbPAF 537 PVRNLHQSGFSLSGA dbPAF 540 NLHQSGFSLSGAQID dbPAF 542 HQSGFSLSGAQIDDN dbPAF 554 DDNIPRRTTQRIVAP dbPAF 555 DNIPRRTTQRIVAPP dbPAF 569 PGGRANITSLG dbPAF 57 IVPGGVKTIEAHSRM dbPAF 570 GGRANITSLG*** dbPAF 74 PGGIDVHTRFQMPDQ dbPAF
Acetylation (count: 5)	20 TSDRLLIKGGKIVND PLMD 254 NCPLYITKVMSKSSA PLMD 293 DGSHYWSKNWAKAAA PLMD 423 SVKTISAKTHNSSLE PLMD 520 VTPASSAKTSPAKQQ PLMD
Ubiquitination (count: 14) (view all)	254 NCPLYITKVMSKSSA PLMD 258 YITKVMSKSSAEVIA PLMD 269 EVIAQARKKGTVVYG PLMD 270 VIAQARKKGTVVYGE PLMD 368 RMSVIWDKAVVTGKM PLMD 374 DKAVVTGKMDENQFV PLMD 390 VTSTNAAKVFNLYPR PLMD 418 IWDPDSVKTISAKTH PLMD 423 SVKTISAKTHNSSLE PLMD 43 YMEDGLIKQIGENLI PLMD 472 SGRYIPRKPFPDFVY PLMD 511 CEVSVTPKTVTPASS PLMD 520 VTPASSAKTSPAKQQ PLMD 525 SAKTSPAKQQAPPVR PLMD
Malonylation (count: 1)	472 SGRYIPRKPFPDFVY PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O14531	Q16555	MINT
O14939	Q16555	HPRD
P49757	Q16555	HPRD
P49841	Q16555	HPRD
P60709	Q16555	MINT
Q13464	Q16555	HPRD
Q13885	Q16555	HPRD
Q14194	Q16555	MINT;HPRD
Q15051	Q16555	IntAct
Q15835	Q16555	MINT
Q16555	Q6B856	MINT
Q16555	Q7Z5P9	BioGRID
Q16555	Q9BPU6	HPRD
Q16555	Q9NRI5	IntAct
Q16555	Q9UJU2	IntAct
Q16555	Q9Y6V0	BioGRID