| Tag | Content |
|---|---|
| UniProt Accession | CDC37_HUMAN; Q16543; |
| Entrez ID | 11140 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] |
| Gene Name | CDC37; CDC37A |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). |
| Sequence (Fasta) | MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK 60 VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS 120 KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH 180 LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK 240 IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES 300 LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG 360 DPLLEAVPKT GDEKDVSV 379 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 3) | rs7254474; Parkinson's disease (familial); Parkinson's disease
rs7254474; Soluble ICAM-1; fatty liver disease|myocardial infarction rs11879191; Inflammatory bowel disease; inflammatory bowel disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 15) (view all) | 111 EMRKKEKSMPWNVDT dbPAF
118 SMPWNVDTLSKDGFS dbPAF 120 PWNVDTLSKDGFSKS dbPAF 127 SKDGFSKSMVNTKPE dbPAF 13 VWDHIEVSDDEDETH dbPAF 140 PEKTEEDSEEVREQK dbPAF |
| Acetylation (count: 17) (view all) | 101 EERSWEQKLEEMRKK PLMD
110 EEMRKKEKSMPWNVD PLMD 121 WNVDTLSKDGFSKSM PLMD 126 LSKDGFSKSMVNTKP PLMD 132 SKSMVNTKPEKTEED PLMD 154 KHKTFVEKYEKQIKH PLMD |
| Ubiquitination (count: 21) (view all) | 101 EERSWEQKLEEMRKK PLMD
110 EEMRKKEKSMPWNVD PLMD 121 WNVDTLSKDGFSKSM PLMD 126 LSKDGFSKSMVNTKP PLMD 132 SKSMVNTKPEKTEED PLMD 135 MVNTKPEKTEEDSEE PLMD |
| Sumoylation (count: 1) | 132 SKSMVNTKPEKTEED PLMD |
| Malonylation (count: 3) | 101 EERSWEQKLEEMRKK PLMD
154 KHKTFVEKYEKQIKH PLMD 69 AECQRKLKELEVAEG PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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