Tag | Content |
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UniProt Accession | MK14_HUMAN; Q16539; |
Entrez ID | 1432 |
GenBank Protein ID | NM_001315.2; NM_139012.2; NM_139013.2; NM_139014.2; |
GenBank Nucleotide ID | NP_001306.1; NP_620581.1; NP_620582.1; NP_620583.1; |
Protein Name | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 a |
Gene Name | MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which (view all) |
Sequence (Fasta) | MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 60 SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 120 KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180 GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG 240 TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 300 QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES 360 361 |
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Database | Annotation |
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CTD (Curated) (count: 6) | MESH:D009202
; Cardiomyopathies MESH:D002779 ; Cholestasis MESH:D015464 ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive MESH:D008113 ; Liver Neoplasms MESH:D008175 ; Lung Neoplasms MESH:D017202 ; Myocardial Ischemia |
DisGeNet (Curated) (count: 11) (view all) | C0008370; Cholestasis
C0023473; Myeloid Leukemia, Chronic C0023903; Liver neoplasms C0024121; Lung Neoplasms C0024809; Marijuana Abuse C0036341; Schizophrenia |
GWASdb (count: 4) | rs17714205; Multiple complex diseases; Null
rs2237093; Multiple complex diseases; Null rs2237093; Type 1 diabetes; type 1 diabetes mellitus rs851006; Premature ovarian failure; premature ovarian failure |
PTM | Modification Sites |
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Phosphorylation (count: 16) (view all) | 123 IVKCQKLTDDHVQFL dbPAF
16 YRQELNKTIWEVPER dbPAF 175 DFGLARHTDDEMTGY dbPAF 180 RHTDDEMTGYVATRW dbPAF 182 TDDEMTGYVATRWYR dbPAF 185 EMTGYVATRWYRAPE dbPAF |
Acetylation (count: 3) | 152 DIIHRDLKPSNLAVN PLMD
233 TDHIDQLKLILRLVG PLMD 53 TGLRVAVKKLSRPFQ PLMD |
Ubiquitination (count: 12) (view all) | 121 NNIVKCQKLTDDHVQ PLMD
139 YQILRGLKYIHSADI PLMD 15 FYRQELNKTIWEVPE PLMD 152 DIIHRDLKPSNLAVN PLMD 233 TDHIDQLKLILRLVG PLMD 248 TPGAELLKKISSESA PLMD |
Sumoylation (count: 1) | 79 LRLLKHMKHENVIGL PLMD |