Q15831

※ Protein Information

Tag	Content
UniProt Accession	STK11_HUMAN; Q15831;
Entrez ID	6794
GenBank Protein ID	NM_000455.4; XM_005259618.3;
GenBank Nucleotide ID	NP_000446.1; XP_005259675.1;
Protein Name	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)
Gene Name	STK11; LKB1; PJS
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53(view all) Functional Description Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).;Isoform 2: Has a role in spermiogenesis.
Sequence (Fasta)	MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY 60 GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE 120 EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG 180 NLLLTTGGTL KISDLGVAEA LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS 240 AGVTLYNITT GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI 300 RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED EDLFDIEDDI 360 IYTQDFTVPG QVPEEEASHN GQRRGLPKAV CMNGTEAAQL STKSRAEGRA PNPARKACSA 420 SSKIRRLSAC KQQ 434 Fasta Sequence >Q15831\|STK11; LKB1; PJS\|Homo sapiens (Human) MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Threonine Phosphorylation	Peutz-Jeghers syndrome	P	T336	11853558
1	[Reference]: We show that phosphorylation of LKB1 does not directly affect its nuclear localization or its catalytic activity in vitro, but that its phosphorylation at Thr(336), and perhaps to a lesser extent at Thr(366), inhibits LKB1 from suppressing cell growth.
2	Threonine Phosphorylation	Peutz-Jeghers syndrome	P	T363	11853558
2	[Reference]: We show that phosphorylation of LKB1 does not directly affect its nuclear localization or its catalytic activity in vitro, but that its phosphorylation at Thr(336), and perhaps to a lesser extent at Thr(366), inhibits LKB2 from suppressing cell growth.

※ Disease Cross-ref Annotation

Database	Annotation
Cancer Gene Census	NSCLC, pancreatic jejunal hamartoma, ovarian, testicular, pancreatic Peutz-Jeghers syndrome
CTD (Curated) (count: 10) (view all)	MESH:D000230 ; Adenocarcinoma MESH:C538231 ; Adenocarcinoma of lung MESH:D002294 ; Carcinoma, Squamous Cell MESH:D006973 ; Hypertension MESH:D017379 ; Hypertrophy, Left Ventricular MESH:D044483 ; Intestinal Polyposis MESH:D008175 ; Lung Neoplasms MESH:D010190 ; Pancreatic Neoplasms MESH:D010580 ; Peutz-Jeghers Syndrome MESH:C563236 ; Testicular Germ Cell Tumor
HGMD (count: 229) (view all)	CP055819; Peutz-Jeghers syndrome; Complex rearrangements CP995119; Peutz-Jeghers syndrome; Complex rearrangements CP984562; Peutz-Jeghers syndrome; Complex rearrangements CD032761; Peutz-Jeghers syndrome; Small deletions CD064644; Peutz-Jeghers syndrome; Small deletions CD991887; Peutz-Jeghers syndrome; Small deletions CD991886; Peutz-Jeghers syndrome; Small deletions CD982964; Peutz-Jeghers syndrome; Small deletions CD982958; Peutz-Jeghers syndrome; Small deletions CD032760; Peutz-Jeghers syndrome; Small deletions CD991889; Peutz-Jeghers syndrome; Small deletions CD982959; Peutz-Jeghers syndrome; Small deletions CD982955; Peutz-Jeghers syndrome; Small deletions CD001917; Peutz-Jeghers syndrome; Small deletions CD044167; Peutz-Jeghers syndrome; Small deletions CD044169; Peutz-Jeghers syndrome; Small deletions CD012012; Peutz-Jeghers syndrome; Small deletions CD044168; Peutz-Jeghers syndrome; Small deletions CD082208; Peutz-Jeghers syndrome; Small deletions CD991880; Peutz-Jeghers syndrome; Small deletions CD050018; Peutz-Jeghers syndrome; Small deletions CD090873; Peutz-Jeghers syndrome; Small deletions CD041178; Peutz-Jeghers syndrome; Small deletions CD055730; Peutz-Jeghers syndrome; Small deletions CD991881; Peutz-Jeghers syndrome; Small deletions CD982957; Peutz-Jeghers syndrome; Small deletions CD983984; Peutz-Jeghers syndrome; Small deletions CD051786; Peutz-Jeghers syndrome; Small deletions CD077783; Peutz-Jeghers syndrome ?; Small deletions CD012011; Peutz-Jeghers syndrome; Small deletions CD982961; Peutz-Jeghers syndrome; Small deletions CD041177; Peutz-Jeghers syndrome; Small deletions CD044164; Peutz-Jeghers syndrome; Small deletions CD982954; Peutz-Jeghers syndrome; Small deletions CD032762; Peutz-Jeghers syndrome; Small deletions CD055731; Peutz-Jeghers syndrome; Small deletions CD022293; Peutz-Jeghers syndrome; Small deletions CD044165; Peutz-Jeghers syndrome; Small deletions CD044166; Peutz-Jeghers syndrome; Small deletions CD051787; Peutz-Jeghers syndrome; Small deletions CD075564; Peutz-Jeghers syndrome ?; Small deletions CD055732; Peutz-Jeghers syndrome; Small deletions CD991882; Peutz-Jeghers syndrome; Small deletions CD012010; Peutz-Jeghers syndrome; Small deletions CD982956; Peutz-Jeghers syndrome; Small deletions CD982962; Peutz-Jeghers syndrome; Small deletions CD991884; Peutz-Jeghers syndrome; Small deletions CD012014; Peutz-Jeghers syndrome; Small deletions CD062237; Peutz-Jeghers syndrome; Small deletions CD012015; Peutz-Jeghers syndrome; Small deletions CD004817; Peutz-Jeghers syndrome; Small deletions CD982960; Peutz-Jeghers syndrome; Small deletions CD982963; Peutz-Jeghers syndrome; Small deletions CD051785; Peutz-Jeghers syndrome; Small deletions CD991885; Peutz-Jeghers syndrome; Small deletions CD062238; Peutz-Jeghers syndrome; Small deletions CD035104; Peutz-Jeghers syndrome; Small deletions CD991883; Peutz-Jeghers syndrome; Small deletions CD012013; Peutz-Jeghers syndrome; Small deletions CD991888; Peutz-Jeghers syndrome; Small deletions CG984472; Peutz-Jeghers syndrome; Gross deletions CG984473; Peutz-Jeghers syndrome; Gross deletions CG995016; Peutz-Jeghers syndrome; Gross deletions CG025017; Peutz-Jeghers syndrome; Gross deletions CG025018; Peutz-Jeghers syndrome; Gross deletions CG044455; Peutz-Jeghers syndrome; Gross deletions CG984474; Peutz-Jeghers syndrome; Gross deletions CG056922; Juvenile polyposis coli; Gross deletions CG044456; Peutz-Jeghers syndrome; Gross deletions CG015658; Peutz-Jeghers syndrome; Gross deletions CG984475; Peutz-Jeghers syndrome; Gross deletions CG075876; Peutz-Jeghers syndrome ?; Gross deletions CG055890; Peutz-Jeghers syndrome; Gross deletions CG055891; Peutz-Jeghers syndrome; Gross deletions CG075877; Peutz-Jeghers syndrome ?; Gross deletions CG055892; Peutz-Jeghers syndrome; Gross deletions CG055893; Peutz-Jeghers syndrome; Gross deletions CG075878; Peutz-Jeghers syndrome ?; Gross deletions CG055894; Peutz-Jeghers syndrome; Gross deletions CG055895; Peutz-Jeghers syndrome; Gross deletions CG062354; Peutz-Jeghers syndrome; Gross deletions CG062355; Peutz-Jeghers syndrome; Gross deletions CG062356; Peutz-Jeghers syndrome; Gross deletions CG055896; Peutz-Jeghers syndrome; Gross deletions CG044457; Peutz-Jeghers syndrome; Gross deletions CN005242; Peutz-Jeghers syndrome; Gross insertions CN015749; Peutz-Jeghers syndrome; Gross insertions CN045523; Peutz-Jeghers syndrome; Gross insertions CX984037; Peutz-Jeghers syndrome; Small indels CX067277; Peutz-Jeghers syndrome; Small indels CP044543; Peutz-Jeghers syndrome; Small indels CX983287; Peutz-Jeghers syndrome; Small indels CX012582; Peutz-Jeghers syndrome; Small indels CX055796; Peutz-Jeghers syndrome; Small indels CX075745; Peutz-Jeghers syndrome; Small indels CX075746; Peutz-Jeghers syndrome; Small indels CP995120; Peutz-Jeghers syndrome; Small indels CX075747; Peutz-Jeghers syndrome; Small indels CI044195; Peutz-Jeghers syndrome; Small insertions CI041208; Peutz-Jeghers syndrome; Small insertions CI055775; Peutz-Jeghers syndrome; Small insertions CI004818; Peutz-Jeghers syndrome; Small insertions CI994398; Peutz-Jeghers syndrome; Small insertions CI041206; Peutz-Jeghers syndrome; Small insertions CI051814; Peutz-Jeghers syndrome; Small insertions CI983226; Peutz-Jeghers syndrome; Small insertions CI045120; Peutz-Jeghers syndrome; Small insertions CI983228; Peutz-Jeghers syndrome; Small insertions CI992084; Peutz-Jeghers syndrome; Small insertions CI032784; Peutz-Jeghers syndrome; Small insertions CI075702; Peutz-Jeghers syndrome ?; Small insertions CI055776; Peutz-Jeghers syndrome; Small insertions CI055777; Peutz-Jeghers syndrome; Small insertions CI995131; Peutz-Jeghers syndrome; Small insertions CI051815; Peutz-Jeghers syndrome; Small insertions CI064736; Peutz-Jeghers syndrome; Small insertions CI055778; Peutz-Jeghers syndrome; Small insertions CI064737; Peutz-Jeghers syndrome; Small insertions CI044196; Peutz-Jeghers syndrome; Small insertions CI032783; Peutz-Jeghers syndrome; Small insertions CI983227; Peutz-Jeghers syndrome; Small insertions CI992085; Peutz-Jeghers syndrome; Small insertions CI001589; Peutz-Jeghers syndrome; Small insertions CI055779; Peutz-Jeghers syndrome; Small insertions CI001947; Peutz-Jeghers syndrome; Small insertions CI983229; Peutz-Jeghers syndrome; Small insertions CI090874; Peutz-Jeghers syndrome; Small insertions CI044197; Peutz-Jeghers syndrome; Small insertions CI983225; Peutz-Jeghers syndrome; Small insertions CI994798; Peutz-Jeghers syndrome; Small insertions CI041207; Peutz-Jeghers syndrome; Small insertions CI055780; Peutz-Jeghers syndrome; Small insertions CM044071; Peutz-Jeghers syndrome; Missense/nonsense CM066241; Gonadotrophin-independent precocious puberty; Missense/nonsense CM051648; Peutz-Jeghers syndrome; Missense/nonsense CM981862; Peutz-Jeghers syndrome; Missense/nonsense CM991149; Peutz-Jeghers syndrome; Missense/nonsense CM981863; Peutz-Jeghers syndrome; Missense/nonsense CM981864; Peutz-Jeghers syndrome; Missense/nonsense CM011960; Peutz-Jeghers syndrome; Missense/nonsense CM981865; Peutz-Jeghers syndrome; Missense/nonsense CM062005; Peutz-Jeghers syndrome; Missense/nonsense CM981866; Peutz-Jeghers syndrome; Missense/nonsense CM991150; Peutz-Jeghers syndrome; Missense/nonsense CM991151; Peutz-Jeghers syndrome; Missense/nonsense CM991152; Peutz-Jeghers syndrome; Missense/nonsense CM075023; Peutz-Jeghers syndrome; Missense/nonsense CM011961; Peutz-Jeghers syndrome; Missense/nonsense CM051649; Peutz-Jeghers syndrome; Missense/nonsense CM041078; Peutz-Jeghers syndrome; Missense/nonsense CM044072; Peutz-Jeghers syndrome; Missense/nonsense HM080026; Peutz-Jeghers syndrome; Missense/nonsense CM011962; Peutz-Jeghers syndrome; Missense/nonsense CM011963; Peutz-Jeghers syndrome; Missense/nonsense CM041079; Peutz-Jeghers syndrome; Missense/nonsense CM055546; Peutz-Jeghers syndrome; Missense/nonsense CM991153; Peutz-Jeghers syndrome; Missense/nonsense CM051650; Peutz-Jeghers syndrome; Missense/nonsense CM991154; Peutz-Jeghers syndrome; Missense/nonsense CM044073; Peutz-Jeghers syndrome; Missense/nonsense CM044074; Peutz-Jeghers syndrome; Missense/nonsense CM044075; Peutz-Jeghers syndrome; Missense/nonsense CM044076; Peutz-Jeghers syndrome; Missense/nonsense CM055545; Peutz-Jeghers syndrome; Missense/nonsense CM041080; Peutz-Jeghers syndrome; Missense/nonsense CM013293; Peutz-Jeghers syndrome; Missense/nonsense CM064292; Peutz-Jeghers syndrome; Missense/nonsense CM981867; Peutz-Jeghers syndrome; Missense/nonsense CM021341; Peutz-Jeghers syndrome; Missense/nonsense CM002108; Peutz-Jeghers syndrome; Missense/nonsense CM991155; Peutz-Jeghers syndrome; Missense/nonsense CM011964; Peutz-Jeghers syndrome; Missense/nonsense CM075025; Peutz-Jeghers syndrome ?; Missense/nonsense CM075024; Peutz-Jeghers syndrome ?; Missense/nonsense CM991156; Peutz-Jeghers syndrome; Missense/nonsense CM051651; Peutz-Jeghers syndrome; Missense/nonsense CM991157; Peutz-Jeghers syndrome; Missense/nonsense CM041081; Peutz-Jeghers syndrome; Missense/nonsense CM001344; Peutz-Jeghers syndrome; Missense/nonsense CM075022; Peutz-Jeghers syndrome ?; Missense/nonsense CM022255; Peutz-Jeghers syndrome ?; Missense/nonsense CM044077; Peutz-Jeghers syndrome; Missense/nonsense CM012193; Peutz-Jeghers syndrome; Missense/nonsense CM067471; Peutz-Jeghers syndrome ?; Missense/nonsense CM011965; Peutz-Jeghers syndrome; Missense/nonsense CM051652; Peutz-Jeghers syndrome; Missense/nonsense CM041862; Peutz-Jeghers syndrome; Missense/nonsense CM981868; Peutz-Jeghers syndrome; Missense/nonsense CM981869; Peutz-Jeghers syndrome; Missense/nonsense CM002109; Peutz-Jeghers syndrome; Missense/nonsense CM001345; Peutz-Jeghers syndrome; Missense/nonsense CM067470; Peutz-Jeghers syndrome; Missense/nonsense CM067469; Peutz-Jeghers syndrome ?; Missense/nonsense CM991158; Peutz-Jeghers syndrome; Missense/nonsense CM001792; Peutz-Jeghers syndrome; Missense/nonsense CM981870; Peutz-Jeghers syndrome; Missense/nonsense CM055544; Peutz-Jeghers syndrome; Missense/nonsense CM001793; Peutz-Jeghers syndrome; Missense/nonsense CM991159; Peutz-Jeghers syndrome; Missense/nonsense CM981871; Peutz-Jeghers syndrome; Missense/nonsense CM001346; Peutz-Jeghers syndrome; Missense/nonsense CM041082; Peutz-Jeghers syndrome; Missense/nonsense CM991160; Peutz-Jeghers syndrome; Missense/nonsense CS001462; Peutz-Jeghers syndrome; Splicing CS991505; Peutz-Jeghers syndrome; Splicing CS982372; Peutz-Jeghers syndrome; Splicing CS004815; Peutz-Jeghers syndrome; Splicing CS012223; Peutz-Jeghers syndrome; Splicing CS067505; Peutz-Jeghers syndrome ?; Splicing CS055617; Peutz-Jeghers syndrome; Splicing CS044093; Peutz-Jeghers syndrome; Splicing CS021376; Peutz-Jeghers syndrome; Splicing CS012224; Peutz-Jeghers syndrome; Splicing CS055618; Peutz-Jeghers syndrome; Splicing CS982373; Peutz-Jeghers syndrome; Splicing CS012225; Peutz-Jeghers syndrome; Splicing CS067506; Peutz-Jeghers syndrome ?; Splicing CS064454; Peutz-Jeghers syndrome; Splicing CS044094; Peutz-Jeghers syndrome; Splicing CS012226; Peutz-Jeghers syndrome; Splicing CS012227; Peutz-Jeghers syndrome; Splicing CS982374; Peutz-Jeghers syndrome; Splicing CS001846; Peutz-Jeghers syndrome; Splicing CS044095; Peutz-Jeghers syndrome; Splicing CS035538; Peutz-Jeghers syndrome; Splicing CS991506; Peutz-Jeghers syndrome; Splicing CS035065; Peutz-Jeghers syndrome; Splicing CS032716; Peutz-Jeghers syndrome; Splicing CS041130; Peutz-Jeghers syndrome; Splicing
GWASdb (count: 3)	rs147615524; PR interval in Tripanosoma cruzi seropositivity; Chagas disease\|cardiomyopathy rs3764640; Alzheimer's disease; Alzheimer's disease rs741765; Alzheimer's disease; Alzheimer's disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 14) (view all)	185 KPGNLLLTTGGTLKI dbPAF 189 LLLTTGGTLKISDLG dbPAF 240 GFKVDIWSAGVTLYN dbPAF 307 IRQIRQHSWFRKKHP dbPAF 31 TFIHRIDSTEVIYQP dbPAF 32 FIHRIDSTEVIYQPR dbPAF 325 APVPIPPSPDTKDRW dbPAF 334 DTKDRWRSMTVVPYL dbPAF 336 KDRWRSMTVVPYLED dbPAF 36 IDSTEVIYQPRRKRA dbPAF 363 IEDDIIYTQDFTVPG dbPAF 401 GTEAAQLSTKSRAEG dbPAF 402 TEAAQLSTKSRAEGR dbPAF 428 SSKIRRLSACKQQ** dbPAF

PTM

Modification Sites

Phosphorylation
(count: 14)
(view all)

185       KPGNLLLTTGGTLKI     dbPAF
189       LLLTTGGTLKISDLG     dbPAF
240       GFKVDIWSAGVTLYN     dbPAF
307       IRQIRQHSWFRKKHP     dbPAF
31        TFIHRIDSTEVIYQP     dbPAF
32        FIHRIDSTEVIYQPR     dbPAF

※ Protein-Protein Interaction

Network

Interaction

Source

H0YG33	Q15831	IntAct
O60285	Q15831	IntAct
O75582	Q15831	HPRD
P04637	Q15831	HPRD; IntAct
P07900	Q15831	IntAct
P17612	Q15831	HPRD
P23443	Q15831	HPRD
P48059	Q15831	IntAct
P51532	Q15831	IntAct
P51784	Q15831	IntAct
P51812	Q15831	HPRD
P54646	Q15831	HPRD
P60484	Q15831	HPRD
Q02241	Q15831	IntAct
Q13315	Q15831	HPRD
Q13451	Q15831	IntAct
Q14232	Q15831	IntAct
Q15831	Q15831	HPRD; IntAct
Q15831	Q16543	HPRD; IntAct
Q15831	Q7KZI7	HPRD
Q15831	Q7RTN6	HPRD; DIP; IntAct; MINT
Q15831	Q8N1F8	HPRD
Q15831	Q8NFZ5	HPRD; IntAct
Q15831	Q8TAF3	IntAct
Q15831	Q8TEW0	HPRD; IntAct
Q15831	Q92922	IntAct
Q15831	Q96CW1	IntAct
Q15831	Q96L34	IntAct;HPRD
Q15831	Q9C0K7	HPRD; IntAct
Q15831	Q9H6T3	IntAct
Q15831	Q9H9S4	IntAct
Q15831	Q9HBD4	HPRD
Q15831	Q9NNW5	IntAct
Q15831	Q9NRH2	HPRD; MINT
Q15831	Q9P0L2	HPRD
Q15831	Q9Y376	HPRD; DIP; IntAct; MINT
Q15831	Q9Y3A3	HPRD; IntAct; MINT

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction