Q15797

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SMAD1_HUMAN; Q15797;
Entrez ID 4086
GenBank Protein ID NM_001003688.1; NM_005900.2; XM_005262992.3; XM_006714217.2; XM_011531961.1; XM_011531962.1; XM_011531963.1; XM_011531964.1;
GenBank Nucleotide ID NP_001003688.1; NP_005891.1; XP_005263049.1; XP_006714280.1; XP_011530263.1; XP_011530264.1; XP_011530265.1; XP_011530266.1;
Protein Name Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene Name SMAD1; BSP1; MADH1; MADR1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Sequence
(Fasta)		MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ 60
PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV 120
CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN 180
SHPFPHSPNS SYPNSPGSSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ 240
PMDTNMMAPP LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 300
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC 360
NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW 420
GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS 466

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationNon-small cell lung cancer/carcinomacell linesDS46318687633
[Reference]: Laser Capture Microdissection and Protein Microarray Analysis of Human Non-small Cell Lung Cancer
2Serine PhosphorylationNon-small cell lung cancer/carcinomaDS46518687633
[Reference]: Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 7)
(view all)		rs7694604; Hemoglobin concentration; hemoglobinopathy
rs7662541; Hemoglobin concentration; hemoglobinopathy
rs7662541; Duodenal ulcer; duodenal ulcer
rs7698944; Hemoglobin concentration; hemoglobinopathy
rs2043779; Hemoglobin concentration; hemoglobinopathy
rs7670486; Hemoglobin concentration; hemoglobinopathy

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 16)
(view all)		 10        VTSLFSFTSPAVKRL     dbPAF
11        TSLFSFTSPAVKRLL     dbPAF
127       VCINPYHYKRVESPV     dbPAF
132       YHYKRVESPVLPPVL     dbPAF
146       LVPRHSEYNPQHSLL     dbPAF
187       NSHPFPHSPNSSYPN     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource