| Tag | Content |
|---|---|
| UniProt Accession | SMAD2_HUMAN; Q15796; |
| Entrez ID | 4087 |
| GenBank Protein ID | NM_001003652.3; NM_005901.5; XM_005258259.3; XM_006722451.3; XM_017025745.1; XM_017025746.1; |
| GenBank Nucleotide ID | NP_001003652.1; NP_005892.1; XP_005258316.1; XP_006722514.1; XP_016881234.1; XP_016881235.1; |
| Protein Name | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) |
| Gene Name | SMAD2; MADH2; MADR2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Sequence (Fasta) | MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 60 LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR 120 KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 180 PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 240 MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 300 GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 360 NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 420 GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS 468 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Database | Annotation |
|---|---|
| Cancer Gene Census | colorectal carcinoma, hepatocellular carcinoma |
| CTD (Curated) (count: 6) | MESH:C535662
; Acromicric dysplasia MESH:C566858 ; Copper-Overload Cirrhosis MESH:D019465 ; Craniofacial Abnormalities MESH:D006521 ; Hepatitis, Chronic MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D020257 ; Ventricular Remodeling |
| DisGeNet (Curated) (count: 6) | C0019189; Hepatitis, Chronic
C0023893; Liver Cirrhosis, Experimental C0265287; Acromicric Dysplasia C0376634; Craniofacial Abnormalities C0600519; Ventricular Remodeling C1876165; Copper-Overload Cirrhosis |
| HGMD (count: 1) | CD084228; Congenital heart defects ?; Small deletions
|
| GWASdb (count: 1) | rs8085335; Atopy; hypersensitivity reaction disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 23) (view all) | 102 QWDTTGLYSFSEQTR dbPAF
110 SFSEQTRSLDGRLQV dbPAF 172 YHYQRVETPVLPPVL dbPAF 197 LPPLDDYTHSIPENT dbPAF 2 ******MSSILPFTP dbPAF 21 RLLGWKKSAGGSGGA dbPAF |
| Acetylation (count: 3) | 156 CEYAFNLKKDEVCVN PLMD
19 VKRLLGWKKSAGGSG PLMD 20 KRLLGWKKSAGGSGG PLMD |
| Ubiquitination (count: 3) | 13 PFTPPVVKRLLGWKK PLMD
157 EYAFNLKKDEVCVNP PLMD 54 SLVKKLKKTGRLDEL PLMD |
| Sumoylation (count: 1) | 156 CEYAFNLKKDEVCVN PLMD |