Q15717

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ELAV1_HUMAN; Q15717;
Entrez ID 1994
GenBank Protein ID
GenBank Nucleotide ID
Protein Name ELAV-like protein 1 (Hu-antigen R) (HuR)
Gene Name ELAVL1; HUR
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionRNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).
Sequence
(Fasta)
MSNGYEDHMA EDCRGDIGRT NLIVNYLPQN MTQDELRSLF SSIGEVESAK LIRDKVAGHS 60
LGYGFVNYVT AKDAERAINT LNGLRLQSKT IKVSYARPSS EVIKDANLYI SGLPRTMTQK 120
DVEDMFSRFG RIINSRVLVD QTTGLSRGVA FIRFDKRSEA EEAITSFNGH KPPGSSEPIT 180
VKFAANPNQN KNVALLSQLY HSPARRFGGP VHHQAQRFRF SPMGVDHMSG LSGVNVPGNA 240
SSGWCIFIYN LGQDADEGIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYEEAAM 300
AIASLNGYRL GDKILQVSFK TNKSHK 327

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationColon cancer/carcinomacell lineUS31821310943
[Reference]: High-constitutive HuR phosphorylation at Ser 318 by PKC propagates tumor relevant functions in colon carcinoma cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
MESH:D004715 ; Endometriosis
DisGeNet (Curated)
(count: 1)
C0014175; Endometriosis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 27)
(view all)
100       VSYARPSSEVIKDAN     dbPAF
109       VIKDANLYISGLPRT     dbPAF
111       KDANLYISGLPRTMT     dbPAF
118       SGLPRTMTQKDVEDM     dbPAF
142       SRVLVDQTTGLSRGV     dbPAF
143       RVLVDQTTGLSRGVA     dbPAF
Acetylation
(count: 10)
(view all)
104       RPSSEVIKDANLYIS     PLMD
120       LPRTMTQKDVEDMFS     PLMD
171       ITSFNGHKPPGSSEP     PLMD
182       SSEPITVKFAANPNQ     PLMD
191       AANPNQNKNVALLSQ     PLMD
313       NGYRLGDKILQVSFK     PLMD
Ubiquitination
(count: 12)
(view all)
104       RPSSEVIKDANLYIS     PLMD
120       LPRTMTQKDVEDMFS     PLMD
171       ITSFNGHKPPGSSEP     PLMD
182       SSEPITVKFAANPNQ     PLMD
191       AANPNQNKNVALLSQ     PLMD
313       NGYRLGDKILQVSFK     PLMD
Sumoylation
(count: 1)
320       KILQVSFKTNKSHK*     PLMD
Malonylation
(count: 1)
320       KILQVSFKTNKSHK*     PLMD
Neddylation
(count: 3)
283       IRDFNTNKCKGFGFV     PLMD
313       NGYRLGDKILQVSFK     PLMD
326       FKTNKSHK*******     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource