Tag | Content |
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UniProt Accession | ELAV1_HUMAN; Q15717; |
Entrez ID | 1994 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | ELAV-like protein 1 (Hu-antigen R) (HuR) |
Gene Name | ELAVL1; HUR |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). |
Sequence (Fasta) | MSNGYEDHMA EDCRGDIGRT NLIVNYLPQN MTQDELRSLF SSIGEVESAK LIRDKVAGHS 60 LGYGFVNYVT AKDAERAINT LNGLRLQSKT IKVSYARPSS EVIKDANLYI SGLPRTMTQK 120 DVEDMFSRFG RIINSRVLVD QTTGLSRGVA FIRFDKRSEA EEAITSFNGH KPPGSSEPIT 180 VKFAANPNQN KNVALLSQLY HSPARRFGGP VHHQAQRFRF SPMGVDHMSG LSGVNVPGNA 240 SSGWCIFIYN LGQDADEGIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYEEAAM 300 AIASLNGYRL GDKILQVSFK TNKSHK 327 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D004715 ; Endometriosis |
DisGeNet (Curated) (count: 1) | C0014175; Endometriosis |
PTM | Modification Sites |
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Phosphorylation (count: 27) (view all) | 100 VSYARPSSEVIKDAN dbPAF
109 VIKDANLYISGLPRT dbPAF 111 KDANLYISGLPRTMT dbPAF 118 SGLPRTMTQKDVEDM dbPAF 142 SRVLVDQTTGLSRGV dbPAF 143 RVLVDQTTGLSRGVA dbPAF |
Acetylation (count: 10) (view all) | 104 RPSSEVIKDANLYIS PLMD
120 LPRTMTQKDVEDMFS PLMD 171 ITSFNGHKPPGSSEP PLMD 182 SSEPITVKFAANPNQ PLMD 191 AANPNQNKNVALLSQ PLMD 313 NGYRLGDKILQVSFK PLMD |
Ubiquitination (count: 12) (view all) | 104 RPSSEVIKDANLYIS PLMD
120 LPRTMTQKDVEDMFS PLMD 171 ITSFNGHKPPGSSEP PLMD 182 SSEPITVKFAANPNQ PLMD 191 AANPNQNKNVALLSQ PLMD 313 NGYRLGDKILQVSFK PLMD |
Sumoylation (count: 1) | 320 KILQVSFKTNKSHK* PLMD |
Malonylation (count: 1) | 320 KILQVSFKTNKSHK* PLMD |
Neddylation (count: 3) | 283 IRDFNTNKCKGFGFV PLMD
313 NGYRLGDKILQVSFK PLMD 326 FKTNKSHK******* PLMD |
Network | Interaction | ||
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A | B | Source | |