| Tag | Content |
|---|---|
| UniProt Accession | TRIP6_HUMAN; Q15654; |
| Entrez ID | 7205 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) |
| Gene Name | TRIP6; OIP1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. |
| Sequence (Fasta) | MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP SEQCYQAPGG 60 PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL SSTLAELNGG RGHASRRPDR 120 QAYEPPPPPA YRTGSLKPNP ASPLPASPYG GPTPASYTTA STPAGPAFPV QVKVAQPVRG 180 CGPPRRGASQ ASGPLPGPHF PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG 240 EHGPQVPLSQ PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF 300 HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI LRAMGKAYHP 360 GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS VCGGAIMPEP GQEETVRIVA 420 LDRSFHIGCY KCEECGLLLS SEGECQGCYP LDGHILCKAC SAWRIQELSA TVTTDC 477 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 1) | rs2075756; Plasminogen activator inhibitor type 1 levels (PAI-1); type 2 diabetes mellitus|coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 24) (view all) | 101 DAEIDLLSSTLAELN dbPAF
102 AEIDLLSSTLAELNG dbPAF 103 EIDLLSSTLAELNGG dbPAF 123 RRPDRQAYEPPPPPA dbPAF 131 EPPPPPAYRTGSLKP dbPAF 142 SLKPNPASPLPASPY dbPAF |
| Acetylation (count: 1) | 137 AYRTGSLKPNPASPL PLMD |
| Ubiquitination (count: 2) | 173 PAFPVQVKVAQPVRG PLMD
458 LDGHILCKACSAWRI PLMD |