| Tag | Content |
|---|---|
| UniProt Accession | NR0B2_HUMAN; Q15466; |
| Entrez ID | 8431 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner) |
| Gene Name | NR0B2; SHP |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. |
| Sequence (Fasta) | MSTSQPGACP CQGAASRPAI LYALLSSSLK AVPRPRSRCL CRQHRPVQLC APHRTCREAL 60 DVLAKTVAFL RNLPSFWQLP PQDQRRLLQG CWGPLFLLGL AQDAVTFEVA EAPVPSILKK 120 ILLEEPSSSG GSGQLPDRPQ PSLAAVQWLQ CCLESFWSLE LSPKEYACLK GTILFNPDVP 180 GLQAASHIGH LQQEAHWVLC EVLEPWCPAA QGRLTRVLLT ASTLKSIPTS LLGDLFFRPI 240 IGDVDIAGLL GDMLLLR 258 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D008064 ; Lipidoses MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009765 ; Obesity |
| HGMD (count: 16) (view all) | CD033863; Lower birth weight, association with; Small deletions
CD011173; Obesity; Small deletions CX011254; Obesity; Small indels CM033797; Obesity ?; Missense/nonsense CM010942; Obesity; Missense/nonsense CM033798; Obesity ?; Missense/nonsense |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 1) | 55 QLCAPHRTCREALDV dbPAF |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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