Tag | Content |
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UniProt Accession | KS6A1_HUMAN; Q15418; |
Entrez ID | 6195 |
GenBank Protein ID | NM_001006665.1; NM_001330441.1; NM_002953.3; |
GenBank Nucleotide ID | NP_001006666.1; NP_001317370.1; NP_002944.2; |
Protein Name | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 |
Gene Name | RPS6KA1; MAPKAPK1A; RSK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional ac(view all) |
Sequence (Fasta) | MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS 60 HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 120 HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 180 LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS 240 HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 300 PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 360 KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL HSVVQQLHGK NLVFSDGYVV 420 KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD 480 DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIG KTVEYLHSQG VVHRDLKPSN 540 ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600 GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP 660 HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS 720 ILAQRRVRKL PSTTL 736 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D012751 ; Sezary Syndrome |
GWASdb (count: 4) | rs6670311; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs282177; Multiple sclerosis; multiple sclerosis rs190737; Nonalcoholic fatty liver disease; fatty liver disease rs2229714; Dilated cardiomyopathy; dilated cardiomyopathy |
PTM | Modification Sites |
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Phosphorylation (count: 43) (view all) | 154 GDLFTRLSKEVMFTE dbPAF
204 EEGHIKLTDFGLSKE dbPAF 209 KLTDFGLSKEAIDHE dbPAF 220 IDHEKKAYSFCGTVE dbPAF 221 DHEKKAYSFCGTVEY dbPAF 225 KAYSFCGTVEYMAPE dbPAF |
Acetylation (count: 4) | 433 VGSYSECKRCVHKAT PLMD
56 HVKAGSEKADPSHFE PLMD 587 FVAPEVLKRQGYDEG PLMD 715 SKPTPQLKPIESSIL PLMD |
Ubiquitination (count: 14) (view all) | 278 MTLILKAKLGMPQFL PLMD
316 PDGAEEIKRHVFYST PLMD 392 GLMEDDGKPRAPQAP PLMD 410 VVQQLHGKNLVFSDG PLMD 433 VGSYSECKRCVHKAT PLMD 453 VKVIDKSKRDPSEEI PLMD |
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