| Tag | Content |
|---|---|
| UniProt Accession | L2GL1_HUMAN; Q15334; |
| Entrez ID | 3996 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) |
| Gene Name | LLGL1; DLG4; HUGL; HUGL1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. |
| Sequence (Fasta) | MMKFRFRRQG ADPQREKLKQ ELFAFNKTVE HGFPNQPSAL AFDPELRIMA IGTRSGAVKI 60 YGAPGVEFTG LHRDAATVTQ MHFLTGQGRL LSLLDDSSLH LWEIVHHNGC AHLEEALSFQ 120 LPSRPGFDGA SAPLSLTRVT VVLLVAASDI AALGTEGSSV FFLDVTTLTL LEGQTLAPGE 180 VLRSVPDDYR CGKALGPVES LQGHLRDPTK ILIGYSRGLL VIWNQASQCV DHIFLGNQQL 240 ESLCWGRDSS TVVSSHSDGS YAVWSVDAGS FPTLQPTVAT TPYGPFPCKA INKILWRNCE 300 SGGHFIIFSG GMPRASYGDR HCVSVLRAET LVTLDFTSRI IDFFTVHSTR PEDEFDDPQA 360 LAVLLEEELV VLDLQTPGWP AVPAPYLAPL HSSAITCSAH VASVPAKLWA RIVSAGEQQS 420 PQPVSSALSW PITGGRNLAQ EPSQRGLLLT GHEDGTVRFW DASGVALRPL YKLSTAGLFQ 480 TDCEHADSLA QAAEDDWPPF RKVGCFDPYS DDPRLGVQKV ALCKYTAQMV VAGTAGQVLV 540 LELSDVPVEQ AVSVAIIDLL QDREGFTWKG HERLSPRTGP LPWPAGFQPR VLVQCLPPAA 600 VTAVTLHTEW SLVAFGTSHG FGLFDYQRKS PVLARCTLHP NDSLAMEGPL SRVKSLKKSL 660 RQSFRRIRKS RVSGKKRAAN ASSKLQEANA QLAEQACPHD VEMTPVQRRI EPRSADDSLS 720 GVVRCLYFAD TFLRDGAHHG PTMWAGTNSG SVFAYALEVP AAAVGGEKRP EQAVEAVLGK 780 EVQLMHRAPV VAIAVLDGRG RPLPEPYEAS RDLAQAPDMQ GGHAVLIASE EQFKVFTLPK 840 VSAKTKFKLT AHEGCRVRKV ALATFASVAC EDYAETCLAC LTNLGDVHVF SVPGLRPQVH 900 YSCIRKEDIS GIASCVFTRH GQGFYLISPS EFERFSLSAR NITEPLCSLD INWPRDATQA 960 SYRIRESPKL SQANGTPSIL LAPQSLDGSP DPAHSMGPDT PEPPEAALSP MSIDSATSAD 1020 TTLDTTGDVT VEDVKDFLGS SEESEKNLRN LAEDEAHACA ILIK 1065 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D001943 ; Breast Neoplasms |
| DisGeNet (Curated) (count: 1) | C1458155; Mammary Neoplasms |
| GWASdb (count: 1) | rs2746028; Osteoarthritis (knee and hip); osteoarthritis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 15) (view all) | 1040 DVKDFLGSSEESEKN dbPAF
1041 VKDFLGSSEESEKNL dbPAF 420 VSAGEQQSPQPVSSA dbPAF 488 TDCEHADSLAQAAED dbPAF 509 KVGCFDPYSDDPRLG dbPAF 510 VGCFDPYSDDPRLGV dbPAF |
| Ubiquitination (count: 14) (view all) | 1046 GSSEESEKNLRNLAE PLMD
17 GADPQREKLKQELFA PLMD 19 DPQREKLKQELFAFN PLMD 27 QELFAFNKTVEHGFP PLMD 293 FPCKAINKILWRNCE PLMD 502 DDWPPFRKVGCFDPY PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |