Q15303

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ERBB4_HUMAN; Q15303;
Entrez ID 2066
GenBank Protein ID NM_001042599.1; NM_005235.2; XM_005246376.2; XM_005246377.2;
GenBank Nucleotide ID NP_001036064.1; NP_005226.1; XP_005246433.1; XP_005246434.1;
Protein Name Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene Name ERBB4; HER4
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal(view all)
Sequence
(Fasta)
MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 60
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 120
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST 180
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 240
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 300
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 360
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 420
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 480
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD 540
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 600
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 660
LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 720
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL 780
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 840
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 900
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID 960
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 1020
EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP 1080
YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS 1140
PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED 1200
EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ 1260
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV 1309

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationBreast cancer/tumor/carcinomaP11389077
[Reference]: p85-sErbB3 inhibits HRG-induced phosphorylation of ErbB2, ErbB3, and ErbB4 in breast carcinoma-derived cell lines and can also block HRG-stimulated activation of mitogen-activated protein kinase, Akt, and association of ErbB3 with the phosphatidylinositol 3'-kinase p85 regulatory subunit.

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
melanoma, gastric, NSCLC
CTD (Curated)
(count: 4)
OMIM:615515 ; AMYOTROPHIC LATERAL SCLEROSIS 19
MESH:D005706 ; Gallbladder Neoplasms
MESH:D008545 ; Melanoma
MESH:D012878 ; Skin Neoplasms
DisGeNet (Curated)
(count: 32)
(view all)
C0002736; Amyotrophic Lateral Sclerosis
C0003467; Anxiety
C0005586; Bipolar Disorder
C0011581; Depressive disorder
C0013404; Dyspnea
C0015672; Fatigue
HGMD
(count: 3)
CP090901; Epileptic encephalopathy, early infantile 3; Complex rearrangements
CR076695; Breast and colorectal cancer, association with; Regulatory
CR076696; Increased promoter activity, association with; Regulatory
GWASdb
(count: 105)
(view all)
rs1595066; Monocyte chemoattractant protein-1; obesity
rs10932374; Paclitaxel-induced neuropathy; sensory peripheral neuropathy
rs10932374; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease
rs17744862; Lung function (forced expiratory flow between 25% and 75% of forced vital capacity); lung disease
rs3791682; Myopia (pathological); myopia
rs3791682; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 28)
(view all)
1022      DMMDAEEYLVPQAFN     dbPAF
1035      FNIPPPIYTSRARID     dbPAF
1056      GHSPPPAYTPMSGNQ     dbPAF
1066      MSGNQFVYRDGGFAA     dbPAF
1081      EQGVSVPYRAPTSTI     dbPAF
1128      EDSSTQRYSADPTVF     dbPAF
Acetylation
(count: 2)
873       RLLEGDEKEYNADGG     PLMD
881       EYNADGGKMPIKWMA     PLMD
Ubiquitination
(count: 3)
1265      YLQEYSTKYFYKQNG     PLMD
722       ETELKRVKVLGSGAF     PLMD
745       VPEGETVKIPVAIKI     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
O00459Q15303HPRD; MINT
O14511Q15303HPRD
O14944Q15303HPRD
O43639Q15303MINT
P00519Q15303MINT
P00533Q15303HPRD; IntAct
P01135Q15303HPRD
P04626Q15303HPRD; IntAct
P10276Q15303IntAct
P15941Q15303HPRD
P16070Q15303HPRD
P20936Q15303MINT
P21860Q15303HPRD; IntAct
P29279Q15303HPRD
P29353Q15303MINT;HPRD
P35070Q15303HPRD
P42229Q15303HPRD
P42684Q15303MINT
P43405Q15303MINT
P46108Q15303HPRD
P46109Q15303MINT
P46937Q15303HPRD
P51692Q15303HPRD; MINT
P56975Q15303HPRD
P62988Q15303DIP
P62993Q15303HPRD; MINT
P78352Q15303IntAct;HPRD
P78536Q15303HPRD
Q02297Q15303HPRD; DIP
Q05586Q15303IntAct
Q06124Q15303MINT
Q12816Q15303IntAct
Q12959Q15303HPRD
Q13425Q15303HPRD; IntAct
Q15303Q15303HPRD; DIP
Q15303Q15700IntAct;HPRD
Q15303Q5JUW8MINT
Q15303Q7Z6G8MINT
Q15303Q8WWG1HPRD
Q15303Q92625MINT
Q15303Q92796HPRD; IntAct
Q15303Q96J02DIP
Q15303Q99075HPRD
Q15303Q9H4P4HPRD
Q15303Q9NZC7IntAct
Q15303Q9UBN7IntAct