Tag | Content |
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UniProt Accession | ERBB4_HUMAN; Q15303; |
Entrez ID | 2066 |
GenBank Protein ID | NM_001042599.1; NM_005235.2; XM_005246376.2; XM_005246377.2; |
GenBank Nucleotide ID | NP_001036064.1; NP_005226.1; XP_005246433.1; XP_005246434.1; |
Protein Name | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] |
Gene Name | ERBB4; HER4 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal(view all) |
Sequence (Fasta) | MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 60 GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 120 LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST 180 NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 240 PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 300 SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 360 KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 420 VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 480 INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD 540 GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 600 NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 660 LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 720 VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL 780 VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 840 HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 900 SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID 960 ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 1020 EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP 1080 YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS 1140 PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED 1200 EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ 1260 EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV 1309 |
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Database | Annotation |
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Cancer Gene Census | melanoma, gastric, NSCLC |
CTD (Curated) (count: 4) | OMIM:615515
; AMYOTROPHIC LATERAL SCLEROSIS 19 MESH:D005706 ; Gallbladder Neoplasms MESH:D008545 ; Melanoma MESH:D012878 ; Skin Neoplasms |
DisGeNet (Curated) (count: 32) (view all) | C0002736; Amyotrophic Lateral Sclerosis
C0003467; Anxiety C0005586; Bipolar Disorder C0011581; Depressive disorder C0013404; Dyspnea C0015672; Fatigue |
HGMD (count: 3) | CP090901; Epileptic encephalopathy, early infantile 3; Complex rearrangements
CR076695; Breast and colorectal cancer, association with; Regulatory CR076696; Increased promoter activity, association with; Regulatory |
GWASdb (count: 105) (view all) | rs1595066; Monocyte chemoattractant protein-1; obesity
rs10932374; Paclitaxel-induced neuropathy; sensory peripheral neuropathy rs10932374; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease rs17744862; Lung function (forced expiratory flow between 25% and 75% of forced vital capacity); lung disease rs3791682; Myopia (pathological); myopia rs3791682; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease |
PTM | Modification Sites |
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Phosphorylation (count: 28) (view all) | 1022 DMMDAEEYLVPQAFN dbPAF
1035 FNIPPPIYTSRARID dbPAF 1056 GHSPPPAYTPMSGNQ dbPAF 1066 MSGNQFVYRDGGFAA dbPAF 1081 EQGVSVPYRAPTSTI dbPAF 1128 EDSSTQRYSADPTVF dbPAF |
Acetylation (count: 2) | 873 RLLEGDEKEYNADGG PLMD
881 EYNADGGKMPIKWMA PLMD |
Ubiquitination (count: 3) | 1265 YLQEYSTKYFYKQNG PLMD
722 ETELKRVKVLGSGAF PLMD 745 VPEGETVKIPVAIKI PLMD |
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