| Tag | Content |
|---|---|
| UniProt Accession | RABE1_HUMAN; Q15276; |
| Entrez ID | 9135 |
| GenBank Protein ID | NM_001083585.2; NM_001291581.1; NM_004703.5; |
| GenBank Nucleotide ID | NP_001077054.1; NP_001278510.1; NP_004694.2; |
| Protein Name | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) |
| Gene Name | RABEP1; RAB5EP; RABPT5; RABPT5A |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. |
| Sequence (Fasta) | MAQPGPASQP DVSLQQRVAE LEKINAEFLR AQQQLEQEFN QKRAKFKELY LAKEEDLKRQ 60 NAVLQAAQDD LGHLRTQLWE AQAEMENIKA IATVSENTKQ EAIDEVKRQW REEVASLQAV 120 MKETVRDYEH QFHLRLEQER TQWAQYRESA EREIADLRRR LSEGQEEENL ENEMKKAQED 180 AEKLRSVVMP MEKEIAALKD KLTEAEDKIK ELEASKVKEL NHYLEAEKSC RTDLEMYVAV 240 LNTQKSVLQE DAEKLRKELH EVCHLLEQER QQHNQLKHTW QKANDQFLES QRLLMRDMQR 300 MEIVLTSEQL RQVEELKKKD QEDDEQQRLN KRKDHKKADV EEEIKIPVVC ALTQEESSAQ 360 LSNEEEHLDS TRGSVHSLDA GLLLPSGDPF SKSDNDMFKD GLRRAQSTDS LGTSGSLQSK 420 ALGYNYKAKS AGNLDESDFG PLVGADSVSE NFDTASLGSL QMPSGFMLTK DQERAIKAMT 480 PEQEETASLL SSVTQGMESA YVSPSGYRLV SETEWNLLQK EVHNAGNKLG RRCDMCSNYE 540 KQLQGIQIQE AETRDQVKKL QLMLRQANDQ LEKTMKDKQE LEDFIKQSSE DSSHQISALV 600 LRAQASEILL EELQQGLSQA KRDVQEQMAV LMQSREQVSE ELVRLQKDND SLQGKHSLHV 660 SLQQAEDFIL PDTTEALREL VLKYREDIIN VRTAADHVEE KLKAEILFLK EQIQAEQCLK 720 ENLEETLQLE IENCKEEIAS ISSLKAELER IKVEKGQLES TLREKSQQLE SLQEIKISLE 780 EQLKKETAAK ATVEQLMFEE KNKAQRLQTE LDVSEQVQRD FVKLSQTLQV QLERIRQADS 840 LERIRAILND TKLTDINQLP ET 863 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | CMML |
| GWASdb (count: 4) | rs9903704; Cognitive performance; cognitive disorder
rs72634030; Rheumatoid arthritis; rheumatoid arthritis rs3026108; Urinary metabolites; kidney disease rs1065483; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 28) (view all) | 116 QWREEVASLQAVMKE dbPAF
13 PASQPDVSLQQRVAE dbPAF 162 ADLRRRLSEGQEEEN dbPAF 203 AALKDKLTEAEDKIK dbPAF 223 KVKELNHYLEAEKSC dbPAF 306 QRMEIVLTSEQLRQV dbPAF |
| Acetylation (count: 1) | 282 QLKHTWQKANDQFLE PLMD |
| Ubiquitination (count: 10) (view all) | 107 QEAIDEVKRQWREEV PLMD
317 LRQVEELKKKDQEDD PLMD 420 TSGSLQSKALGYNYK PLMD 477 KDQERAIKAMTPEQE PLMD 520 TEWNLLQKEVHNAGN PLMD 586 QELEDFIKQSSEDSS PLMD |
| Glycation (count: 3) | 199 EKEIAALKDKLTEAE PLMD
201 EIAALKDKLTEAEDK PLMD 208 KLTEAEDKIKELEAS PLMD |
| Malonylation (count: 3) | 282 QLKHTWQKANDQFLE PLMD
47 NQKRAKFKELYLAKE PLMD 559 ETRDQVKKLQLMLRQ PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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