Q15170

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TCAL1_HUMAN; Q15170;
Entrez ID 9338
GenBank Protein ID NM_001006639.1; NM_001006640.1; NM_004780.2;
GenBank Nucleotide ID NP_001006640.1; NP_001006641.1; NP_004771.2;
Protein Name Transcription elongation factor A protein-like 1 (TCEA-like protein 1) (Nuclear phosphoprotein p21/SIIR) (Transcription elongation factor S-II protein-like 1)
Gene Name TCEAL1; SIIR
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.
Sequence
(Fasta)		MDKPRKENEE EPQSRPRPMR RGLRWSTLPK SSPPRSSLRR SSPRRRSSFL RSSCLSSCLR 60
CSSRRTPSAG LSRKDLFEGR PPMEQPPCGV GKHKLEEGSF KERLARSRPQ FRGDIHGRNL 120
SNEEMIQAAD ELEEMKRVRN KLMIMHWKAK RSRPYPI 158

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationRous sarcomaPS367592688
[Reference]: The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression.
2Serine PhosphorylationRous sarcomaPS377592688
[Reference]: The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression.


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 11)
(view all)		 121       DIHGRNLSNEEMIQA     dbPAF
155       KAKRSRPYPI*****     dbPAF
27        RRGLRWSTLPKSSPP     dbPAF
31        RWSTLPKSSPPRSSL     dbPAF
32        WSTLPKSSPPRSSLR     dbPAF
36        PKSSPPRSSLRRSSP     dbPAF
Ubiquitination
(count: 1)		 136       ADELEEMKRVRNKLM     PLMD
Sumoylation
(count: 1)		 94        PCGVGKHKLEEGSFK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource