| Tag | Content |
|---|---|
| UniProt Accession | CDK10_HUMAN; Q15131; |
| Entrez ID | 8558 |
| GenBank Protein ID | NM_001098533.2; NM_001160367.1; NM_052987.3; NM_052988.4; XM_017023808.1; XM_017023809.1; XM_017023810.1; |
| GenBank Nucleotide ID | NP_001092003.2; NP_001153839.1; NP_443713.2; NP_443714.3; XP_016879297.1; XP_016879298.1; XP_016879299.1; |
| Protein Name | Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE) |
| Gene Name | CDK10 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). |
| Sequence (Fasta) | MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 60 TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120 EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA 180 DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP 240 GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 300 HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT SEGQSKRCKP 360 361 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 11) (view all) | rs258324; Hair, eye and skin pigmentation; hair disease|iris disease|skin disease
rs258324; Skin sensitivity to sun; skin disease rs258324; Major depressive disorder; major depressive disorder rs258322; Hair, eye and skin pigmentation; hair disease|iris disease|skin disease rs258322; Black vs. red hair color; hair disease rs258322; Skin sensitivity to sun; skin disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 9) (view all) | 133 SLLENMPTPFSEAQV dbPAF
196 GVPVKPMTPKVVTLW dbPAF 320 TAGDCLESSYFKEKP dbPAF 321 AGDCLESSYFKEKPL dbPAF 322 GDCLESSYFKEKPLP dbPAF 49 LNRIGEGTYGIVYRA dbPAF |
| Acetylation (count: 1) | 178 MTDKGCVKTADFGLA PLMD |
| Ubiquitination (count: 5) | 178 MTDKGCVKTADFGLA PLMD
41 RSVKEFEKLNRIGEG PLMD 68 TDEIVALKKVRMDKE PLMD 69 DEIVALKKVRMDKEK PLMD 76 KVRMDKEKDGIPISS PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |