Q15121

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PEA15_HUMAN; Q15121;
Entrez ID 8682
GenBank Protein ID NM_001297576.1; NM_001297577.1; NM_001297578.1; NM_003768.4; XM_006711599.2;
GenBank Nucleotide ID NP_001284505.1; NP_001284506.1; NP_001284507.1; NP_003759.1; XP_006711662.1;
Protein Name Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED)
Gene Name PEA15
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionBlocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Sequence
(Fasta)		MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL 60
SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI 120
IKLAPPPKKA 131

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1DephosphorylationOvarian cancer/carcinomaPS10423552738
[Reference]: PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking -catenin
2DephosphorylationOvarian cancer/carcinomaPS11623552738
[Reference]: PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking -catenin

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs680083; Fibrinogen; cardiovascular system disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)		 100       DELDTKLTRIPSAKK     dbPAF
104       TKLTRIPSAKKYKDI     dbPAF
108       RIPSAKKYKDIIRQP     dbPAF
116       KDIIRQPSEEEIIKL     dbPAF
25        EDLEQLKSACKEDIP     dbPAF
4         ****MAEYGTLLQDL     dbPAF
Acetylation
(count: 1)		 35        KEDIPSEKSEEITTG     PLMD
Ubiquitination
(count: 4)		 109       IPSAKKYKDIIRQPS     PLMD
122       PSEEEIIKLAPPPKK     PLMD
129       KLAPPPKKA******     PLMD
98        EEDELDTKLTRIPSA     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource