Tag | Content |
---|---|
UniProt Accession | PEA15_HUMAN; Q15121; |
Entrez ID | 8682 |
GenBank Protein ID | NM_001297576.1; NM_001297577.1; NM_001297578.1; NM_003768.4; XM_006711599.2; |
GenBank Nucleotide ID | NP_001284505.1; NP_001284506.1; NP_001284507.1; NP_003759.1; XP_006711662.1; |
Protein Name | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) |
Gene Name | PEA15 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. |
Sequence (Fasta) | MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL 60 SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI 120 IKLAPPPKKA 131 |
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Database | Annotation |
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GWASdb (count: 1) | rs680083; Fibrinogen; cardiovascular system disease |
PTM | Modification Sites |
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Phosphorylation (count: 10) (view all) | 100 DELDTKLTRIPSAKK dbPAF
104 TKLTRIPSAKKYKDI dbPAF 108 RIPSAKKYKDIIRQP dbPAF 116 KDIIRQPSEEEIIKL dbPAF 25 EDLEQLKSACKEDIP dbPAF 4 ****MAEYGTLLQDL dbPAF |
Acetylation (count: 1) | 35 KEDIPSEKSEEITTG PLMD |
Ubiquitination (count: 4) | 109 IPSAKKYKDIIRQPS PLMD
122 PSEEEIIKLAPPPKK PLMD 129 KLAPPPKKA****** PLMD 98 EEDELDTKLTRIPSA PLMD |
Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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