Q15102

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PA1B3_HUMAN; Q15102;
Entrez ID 5050
GenBank Protein ID NM_001145939.1; NM_001145940.1; NM_002573.3;
GenBank Nucleotide ID NP_001139411.1; NP_001139412.1; NP_002564.1;
Protein Name Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)
Gene Name PAFAH1B3; PAFAHG
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.
Sequence
(Fasta)		MSGEENPASK PTPVQDVQGD GRWMSLHHRF VADSKDKEPE VVFIGDSLVQ LMHQCEIWRE 60
LFSPLHALNF GIGGDGTQHV LWRLENGELE HIRPKIVVVW VGTNNHGHTA EQVTGGIKAI 120
VQLVNERQPQ ARVVVLGLLP RGQHPNPLRE KNRQVNELVR AALAGHPRAH FLDADPGFVH 180
SDGTISHHDM YDYLHLSRLG YTPVCRALHS LLLRLLAQDQ GQGAPLLEPA P 232

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PalmitoylationCardiovascular/heart diseaseAC5624357059
[Reference]: we confirmed that insulin stimulated palmitoylation without affecting PAFAH1b3 protein abundance. Chemical inhibition of palmitoylation prevented insulin-induced angiogenesis in vitro; knockdown of PAFAH1b3 had the same effect. PAFAH1b3 knockdown also disrupted cell migration
2PalmitoylationCardiovascular/heart diseaseAC20624357059
[Reference]: PAFAH1b3 knockdown also disrupted cell migration. Mutagenesis of cysteines at residues 56 and 206 prevented palmitoylation of PAFAH1b3,

※ Disease Cross-ref Annotation

DatabaseAnnotation
HGMD
(count: 2)		CP015805; Mental retardation, ataxia & atrophy of the brain; Complex rearrangements
CP015806; Mental retardation, ataxia & atrophy of the brain; Complex rearrangements

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)		 12        ENPASKPTPVQDVQG     dbPAF
184       GFVHSDGTISHHDMY     dbPAF
191       TISHHDMYDYLHLSR     dbPAF
2         ******MSGEENPAS     dbPAF
210       PVCRALHSLLLRLLA     dbPAF
Ubiquitination
(count: 1)		 10        GEENPASKPTPVQDV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
H0YG74Q15102MINT
O60383Q15102HPRD; IntAct; MINT
P04406Q15102HPRD; IntAct; MINT
P04637Q15102HPRD; IntAct; MINT
P12956Q15102HPRD; IntAct; MINT
P32456Q15102HPRD; IntAct
P43034Q15102HPRD
P61956Q15102IntAct
P68104Q15102HPRD; IntAct
P68402Q15102HPRD; IntAct; MINT
Q04724Q15102HPRD; IntAct; MINT
Q05516Q15102HPRD; IntAct; MINT
Q13011Q15102HPRD; IntAct; MINT
Q13432Q15102HPRD; IntAct; MINT
Q13885Q15102IntAct; MINT
Q14194Q15102IntAct; MINT;HPRD
Q15047Q15102HPRD; IntAct; MINT
Q15102Q15102HPRD; IntAct; MINT
Q15102Q5RL73HPRD; IntAct
Q15102Q5T3J3HPRD; MINT
Q15102Q5UIP0IntAct
Q15102Q5VTE0MINT
Q15102Q6EEV6HPRD
Q15102Q6P2R5MINT
Q15102Q7L5N1HPRD; IntAct; MINT
Q15102Q8N8V2MINT
Q15102Q8TBB1HPRD; IntAct; MINT
Q15102Q8WUX9HPRD; IntAct; MINT
Q15102Q96ID5HPRD; IntAct; MINT
Q15102Q9C0C9IntAct
Q15102Q9GZR7HPRD; IntAct; MINT
Q15102Q9GZT6HPRD; IntAct; MINT
Q15102Q9H190HPRD; IntAct; MINT
Q15102Q9NPI1IntAct; MINT;HPRD
Q15102Q9UKR5HPRD; IntAct; MINT
Q15102Q9UKY1HPRD; IntAct; MINT
Q15102Q9Y3C7HPRD; IntAct; MINT
Q15102Q9Y4G2HPRD; IntAct