Tag | Content |
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UniProt Accession | NUMA1_HUMAN; Q14980; |
Entrez ID | 4926 |
GenBank Protein ID | NM_001286561.1; NM_006185.3; XM_006718564.1; |
GenBank Nucleotide ID | NP_001273490.1; NP_006176.2; XP_006718627.1; |
Protein Name | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) |
Gene Name | NUMA1; NMP22; NUMA |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaph(view all) |
Sequence (Fasta) | MTLHATRGAA LLSWVNSLHV ADPVEAVLQL QDCSIFIKII DRIHGTEEGQ QILKQPVSER 60 LDFVCSFLQK NRKHPSSPEC LVSAQKVLEG SELELAKMTM LLLYHSTMSS KSPRDWEQFE 120 YKIQAELAVI LKFVLDHEDG LNLNEDLENF LQKAPVPSTC SSTFPEELSP PSHQAKREIR 180 FLELQKVASS SSGNNFLSGS PASPMGDILQ TPQFQMRRLK KQLADERSNR DELELELAEN 240 RKLLTEKDAQ IAMMQQRIDR LALLNEKQAA SPLEPKELEE LRDKNESLTM RLHETLKQCQ 300 DLKTEKSQMD RKINQLSEEN GDLSFKLREF ASHLQQLQDA LNELTEEHSK ATQEWLEKQA 360 QLEKELSAAL QDKKCLEEKN EILQGKLSQL EEHLSQLQDN PPQEKGEVLG DVLQLETLKQ 420 EAATLAANNT QLQARVEMLE TERGQQEAKL LAERGHFEEE KQQLSSLITD LQSSISNLSQ 480 AKEELEQASQ AHGARLTAQV ASLTSELTTL NATIQQQDQE LAGLKQQAKE KQAQLAQTLQ 540 QQEQASQGLR HQVEQLSSSL KQKEQQLKEV AEKQEATRQD HAQQLATAAE EREASLRERD 600 AALKQLEALE KEKAAKLEIL QQQLQVANEA RDSAQTSVTQ AQREKAELSR KVEELQACVE 660 TARQEQHEAQ AQVAELELQL RSEQQKATEK ERVAQEKDQL QEQLQALKES LKVTKGSLEE 720 EKRRAADALE EQQRCISELK AETRSLVEQH KRERKELEEE RAGRKGLEAR LQQLGEAHQA 780 ETEVLRRELA EAMAAQHTAE SECEQLVKEV AAWRERYEDS QQEEAQYGAM FQEQLMTLKE 840 ECEKARQELQ EAKEKVAGIE SHSELQISRQ QNELAELHAN LARALQQVQE KEVRAQKLAD 900 DLSTLQEKMA ATSKEVARLE TLVRKAGEQQ ETASRELVKE PARAGDRQPE WLEEQQGRQF 960 CSTQAALQAM EREAEQMGNE LERLRAALME SQGQQQEERG QQEREVARLT QERGRAQADL 1020 ALEKAARAEL EMRLQNALNE QRVEFATLQE ALAHALTEKE GKDQELAKLR GLEAAQIKEL 1080 EELRQTVKQL KEQLAKKEKE HASGSGAQSE AAGRTEPTGP KLEALRAEVS KLEQQCQKQQ 1140 EQADSLERSL EAERASRAER DSALETLQGQ LEEKAQELGH SQSALASAQR ELAAFRTKVQ 1200 DHSKAEDEWK AQVARGRQEA ERKNSLISSL EEEVSILNRQ VLEKEGESKE LKRLVMAESE 1260 KSQKLEERLR LLQAETASNS ARAAERSSAL REEVQSLREE AEKQRVASEN LRQELTSQAE 1320 RAEELGQELK AWQEKFFQKE QALSTLQLEH TSTQALVSEL LPAKHLCQQL QAEQAAAEKR 1380 HREELEQSKQ AAGGLRAELL RAQRELGELI PLRQKVAEQE RTAQQLRAEK ASYAEQLSML 1440 KKAHGLLAEE NRGLGERANL GRQFLEVELD QAREKYVQEL AAVRADAETR LAEVQREAQS 1500 TARELEVMTA KYEGAKVKVL EERQRFQEER QKLTAQVEQL EVFQREQTKQ VEELSKKLAD 1560 SDQASKVQQQ KLKAVQAQGG ESQQEAQRLQ AQLNELQAQL SQKEQAAEHY KLQMEKAKTH 1620 YDAKKQQNQE LQEQLRSLEQ LQKENKELRA EAERLGHELQ QAGLKTKEAE QTCRHLTAQV 1680 RSLEAQVAHA DQQLRDLGKF QVATDALKSR EPQAKPQLDL SIDSLDLSCE EGTPLSITSK 1740 LPRTQPDGTS VPGEPASPIS QRLPPKVESL ESLYFTPIPA RSQAPLESSL DSLGDVFLDS 1800 GRKTRSARRR TTQIINITMT KKLDVEEPDS ANSSFYSTRS APASQASLRA TSSTQSLARL 1860 GSPDYGNSAL LSLPGYRPTT RSSARRSQAG VSSGAPPGRN SFYMGTCQDE PEQLDDWNRI 1920 AELQQRNRVC PPHLKTCYPL ESRPSLSLGT ITDEEMKTGD PQETLRRASM QPIQIAEGTG 1980 ITTRQQRKRV SLEPHQGPGT PESKKATSCF PRPMTPRDRH EGRKQSTTEA QKKAAPASTK 2040 QADRRQSMAF SILNTPKKLG NSLLRRGASK KALSKASPNT RSGTRRSPRI ATTTASAATA 2100 AAIGATPRAK GKAKH 2116 |
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Database | Annotation |
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Cancer Gene Census | APL |
CTD (Curated) (count: 2) | MESH:D017449
; Dermatitis, Allergic Contact MESH:D015473 ; Leukemia, Promyelocytic, Acute |
GWASdb (count: 5) | rs5743684; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs2298456; Multiple complex diseases; Null rs10898815; Blood pressure (response to calcium channel blocker); hypertension rs4945434; Multiple complex diseases; Null rs679926; Multiple complex diseases; Null |
PTM | Modification Sites |
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Phosphorylation (count: 133) (view all) | 107 MLLLYHSTMSSKSPR dbPAF
1103 KKEKEHASGSGAQSE dbPAF 1105 EKEHASGSGAQSEAA dbPAF 1109 ASGSGAQSEAAGRTE dbPAF 112 HSTMSSKSPRDWEQF dbPAF 1145 KQQEQADSLERSLEA dbPAF |
Acetylation (count: 49) (view all) | 1024 QADLALEKAARAELE PLMD
1088 EELRQTVKQLKEQLA PLMD 1099 EQLAKKEKEHASGSG PLMD 111 YHSTMSSKSPRDWEQ PLMD 1121 RTEPTGPKLEALRAE PLMD 1131 ALRAEVSKLEQQCQK PLMD |
Ubiquitination (count: 54) (view all) | 1024 QADLALEKAARAELE PLMD
1078 GLEAAQIKELEELRQ PLMD 1121 RTEPTGPKLEALRAE PLMD 1131 ALRAEVSKLEQQCQK PLMD 1138 KLEQQCQKQQEQADS PLMD 1174 LQGQLEEKAQELGHS PLMD |
Sumoylation (count: 5) | 1766 ISQRLPPKVESLESL PLMD
1822 INITMTKKLDVEEPD PLMD 2033 STTEAQKKAAPASTK PLMD 2058 SILNTPKKLGNSLLR PLMD 276 AASPLEPKELEELRD PLMD |
Glycation (count: 2) | 1059 LAHALTEKEGKDQEL PLMD
1062 ALTEKEGKDQELAKL PLMD |
Malonylation (count: 1) | 891 ALQQVQEKEVRAQKL PLMD |
Methylation (count: 1) | 1803 VFLDSGRKTRSARRR PLMD |
Succinylation (count: 1) | 708 QEQLQALKESLKVTK PLMD |
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