| Tag | Content |
|---|---|
| UniProt Accession | NOLC1_HUMAN; Q14978; |
| Entrez ID | 9221 |
| GenBank Protein ID | NM_001284388.1; NM_001284389.1; NM_004741.4; |
| GenBank Nucleotide ID | NP_001271317.1; NP_001271318.1; NP_004732.2; |
| Protein Name | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) |
| Gene Name | NOLC1; KIAA0035; NS5ATP13 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). |
| Sequence (Fasta) | MADAGIRRVV PSDLYPLVLG FLRDNQLSEV ANKFAKATGA TQQDANASSL LDIYSFWLKS 60 AKVPERKLQA NGPVAKKAKK KASSSDSEDS SEEEEEVQGP PAKKAAVPAK RVGLPPGKAA 120 AKASESSSSE ESSDDDDEED QKKQPVQKGV KPQAKAAKAP PKKAKSSDSD SDSSSEDEPP 180 KNQKPKITPV TVKAQTKAPP KPARAAPKIA NGKAASSSSS SSSSSSSDDS EEEKAAATPK 240 KTVPKKQVVA KAPVKAATTP TRKSSSSEDS SSDEEEEQKK PMKNKPGPYS SVPPPSAPPP 300 KKSLGTQPPK KAVEKQQPVE SSEDSSDESD SSSEEEKKPP TKAVVSKATT KPPPAKKAAE 360 SSSDSSDSDS SEDDEAPSKP AGTTKNSSNK PAVTTKSPAV KPAAAPKQPV GGGQKLLTRK 420 ADSSSSEEES SSSEEEKTKK MVATTKPKAT AKAALSLPAK QAPQGSRDSS SDSDSSSSEE 480 EEEKTSKSAV KKKPQKVAGG AAPSKPASAK KGKAESSNSS SSDDSSEEEE EKLKGKGSPR 540 PQAPKANGTS ALTAQNGKAA KNSEEEEEEK KKAAVVVSKS GSLKKRKQNE AAKEAETPQA 600 KKIKLQTPNT FPKRKKGEKR ASSPFRRVRE EEIEVDSRVA DNSFDAKRGA AGDWGERANQ 660 VLKFTKGKSF RHEKTKKKRG SYRGGSISVQ VNSIKFDSE |
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| Database | Annotation |
|---|---|
| GWASdb (count: 2) | rs11191224; Prostate cancer (advanced); prostate cancer
rs1049466; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 106) (view all) | 124 GKAAAKASESSSSEE dbPAF
126 AAAKASESSSSEESS dbPAF 127 AAKASESSSSEESSD dbPAF 128 AKASESSSSEESSDD dbPAF 129 KASESSSSEESSDDD dbPAF 132 ESSSSEESSDDDDEE dbPAF |
| Acetylation (count: 30) (view all) | 110 KKAAVPAKRVGLPPG PLMD
118 RVGLPPGKAAAKASE PLMD 193 KITPVTVKAQTKAPP PLMD 197 VTVKAQTKAPPKPAR PLMD 251 PKKQVVAKAPVKAAT PLMD 255 VVAKAPVKAATTPTR PLMD |
| Ubiquitination (count: 9) (view all) | 193 KITPVTVKAQTKAPP PLMD
197 VTVKAQTKAPPKPAR PLMD 33 QLSEVANKFAKATGA PLMD 36 EVANKFAKATGATQQ PLMD 59 DIYSFWLKSAKVPER PLMD 602 AETPQAKKIKLQTPN PLMD |
| Sumoylation (count: 8) (view all) | 193 KITPVTVKAQTKAPP PLMD
407 VKPAAAPKQPVGGGQ PLMD 415 QPVGGGQKLLTRKAD PLMD 572 EEEEEKKKAAVVVSK PLMD 604 TPQAKKIKLQTPNTF PLMD 647 ADNSFDAKRGAAGDW PLMD |
| Malonylation (count: 1) | 33 QLSEVANKFAKATGA PLMD |
| Methylation (count: 1) | 80 PVAKKAKKKASSSDS PLMD |
| Succinylation (count: 1) | 647 ADNSFDAKRGAAGDW PLMD |