Q14934

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession NFAC4_HUMAN; Q14934;
Entrez ID 4776
GenBank Protein ID NM_001136022.2; NM_001198965.1; NM_001198966.2; NM_001198967.2; NM_001288802.1; NM_001320043.1; NM_004554.4; XM_011536797.2; XM_011536799.2;
GenBank Nucleotide ID NP_001129494.1; NP_001185894.1; NP_001185895.1; NP_001185896.1; NP_001275731.1; NP_001306972.1; NP_004545.2; XP_011535099.1; XP_011535101.1;
Protein Name Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)
Gene Name NFATC4; NFAT3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPlays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
Sequence
(Fasta)
MGAASCEDEE LEFKLVFGEE KEAPPLGAGG LGEELDSEDA PPCCRLALGE PPPYGAAPIG 60
IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS 120
ISPTPEPPAA LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS 180
FFSDASDEAA LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG 240
RGPEDSWLLL SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP 300
PPLPLARDPG SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE 360
SVAPPGGSRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR 420
IEVQPRAHHR AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA 480
FYQVHRITGK MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE 540
TDIGRKNTRV RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG 600
GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR 660
PVQVYFYVSN GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP 720
PYPSYPHEDP ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTGCAQPPAV 780
SFLPRPFPSD PYGGRGSSFS LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY 840
NKVGPGYGPG EGAPEQEKSR GGYSSGFRDS VPIQGITLEE VSEIIGRDLS GFPAPPGEEP 900
PA 903

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationSquamous cell carcinomaUS25927893713
[Reference]: Importantly, we showed that CDK3, NFAT3 and phosphorylated NFAT3-Ser259 were highly expressed in skin cancer compared with normal skin tissues. These results provided evidence supporting the oncogenic potential of NFAT3 and suggested that CDK3-mediated phosphorylation of NFAT3 has an important role in skin tumorigenesis.
2Serine PhosphorylationMelanomaUS25927893713
[Reference]: Importantly, we showed that CDK3, NFAT3 and phosphorylated NFAT3-Ser259 were highly expressed in skin cancer compared with normal skin tissues. These results provided evidence supporting the oncogenic potential of NFAT3 and suggested that CDK3-mediated phosphorylation of NFAT3 has an important role in skin tumorigenesis.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 3)
rs2295298; Hemoglobin concentration; hemoglobinopathy
rs11628929; Hemoglobin concentration; hemoglobinopathy
rs3742517; Hemoglobin concentration; hemoglobinopathy

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 32)
(view all)
122       SIRITSISPTPEPPA     dbPAF
168       QGGGAFFSPSPGSSS     dbPAF
170       GGAFFSPSPGSSSLS     dbPAF
173       FFSPSPGSSSLSSWS     dbPAF
213       ASRFGLGSPLPSPRA     dbPAF
217       GLGSPLPSPRASPRP     dbPAF
Sumoylation
(count: 1)
689       RFLPVICKEEPLPDS     PLMD