Tag | Content |
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UniProt Accession | NFAC4_HUMAN; Q14934; |
Entrez ID | 4776 |
GenBank Protein ID | NM_001136022.2; NM_001198965.1; NM_001198966.2; NM_001198967.2; NM_001288802.1; NM_001320043.1; NM_004554.4; XM_011536797.2; XM_011536799.2; |
GenBank Nucleotide ID | NP_001129494.1; NP_001185894.1; NP_001185895.1; NP_001185896.1; NP_001275731.1; NP_001306972.1; NP_004545.2; XP_011535099.1; XP_011535101.1; |
Protein Name | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) |
Gene Name | NFATC4; NFAT3 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. |
Sequence (Fasta) | MGAASCEDEE LEFKLVFGEE KEAPPLGAGG LGEELDSEDA PPCCRLALGE PPPYGAAPIG 60 IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS 120 ISPTPEPPAA LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS 180 FFSDASDEAA LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG 240 RGPEDSWLLL SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP 300 PPLPLARDPG SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE 360 SVAPPGGSRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR 420 IEVQPRAHHR AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA 480 FYQVHRITGK MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE 540 TDIGRKNTRV RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG 600 GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR 660 PVQVYFYVSN GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP 720 PYPSYPHEDP ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTGCAQPPAV 780 SFLPRPFPSD PYGGRGSSFS LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY 840 NKVGPGYGPG EGAPEQEKSR GGYSSGFRDS VPIQGITLEE VSEIIGRDLS GFPAPPGEEP 900 PA 903 |
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Database | Annotation |
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GWASdb (count: 3) | rs2295298; Hemoglobin concentration; hemoglobinopathy
rs11628929; Hemoglobin concentration; hemoglobinopathy rs3742517; Hemoglobin concentration; hemoglobinopathy |
PTM | Modification Sites |
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Phosphorylation (count: 32) (view all) | 122 SIRITSISPTPEPPA dbPAF
168 QGGGAFFSPSPGSSS dbPAF 170 GGAFFSPSPGSSSLS dbPAF 173 FFSPSPGSSSLSSWS dbPAF 213 ASRFGLGSPLPSPRA dbPAF 217 GLGSPLPSPRASPRP dbPAF |
Sumoylation (count: 1) | 689 RFLPVICKEEPLPDS PLMD |