| Tag | Content |
|---|---|
| UniProt Accession | MYPC3_HUMAN; Q14896; |
| Entrez ID | 4607 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform) |
| Gene Name | MYBPC3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Sequence (Fasta) | MPEPGKKPVS AFSKKPRSVE VAAGSPAVFE AETERAGVKV RWQRGGSDIS ASNKYGLATE 60 GTRHTLTVRE VGPADQGSYA VIAGSSKVKF DLKVIEAEKA EPMLAPAPAP AEATGAPGEA 120 PAPAAELGES APSPKGSSSA ALNGPTPGAP DDPIGLFVMR PQDGEVTVGG SITFSARVAG 180 ASLLKPPVVK WFKGKWVDLS SKVGQHLQLH DSYDRASKVY LFELHITDAQ PAFTGSYRCE 240 VSTKDKFDCS NFNLTVHEAM GTGDLDLLSA FRRTSLAGGG RRISDSHEDT GILDFSSLLK 300 KRDSFRTPRD SKLEAPAEED VWEILRQAPP SEYERIAFQY GVTDLRGMLK RLKGMRRDEK 360 KSTAFQKKLE PAYQVSKGHK IRLTVELADH DAEVKWLKNG QEIQMSGSKY IFESIGAKRT 420 LTISQCSLAD DAAYQCVVGG EKCSTELFVK EPPVLITRPL EDQLVMVGQR VEFECEVSEE 480 GAQVKWLKDG VELTREETFK YRFKKDGQRH HLIINEAMLE DAGHYALCTS GGQALAELIV 540 QEKKLEVYQS IADLMVGAKD QAVFKCEVSD ENVRGVWLKN GKELVPDSRI KVSHIGRVHK 600 LTIDDVTPAD EADYSFVPEG FACNLSAKLH FMEVKIDFVP RQEPPKIHLD CPGRIPDTIV 660 VVAGNKLRLD VPISGDPAPT VIWQKAITQG NKAPARPAPD APEDTGDSDE WVFDKKLLCE 720 TEGRVRVETT KDRSIFTVEG AEKEDEGVYT VTVKNPVGED QVNLTVKVID VPDAPAAPKI 780 SNVGEDSCTV QWEPPAYDGG QPILGYILER KKKKSYRWMR LNFDLIQELS HEARRMIEGV 840 VYEMRVYAVN AIGMSRPSPA SQPFMPIGPP SEPTHLAVED VSDTTVSLKW RPPERVGAGG 900 LDGYSVEYCP EGCSEWVAAL QGLTEHTSIL VKDLPTGARL LFRVRAHNMA GPGAPVTTTE 960 PVTVQEILQR PRLQLPRHLR QTIQKKVGEP VNLLIPFQGK PRPQVTWTKE GQPLAGEEVS 1020 IRNSPTDTIL FIRAARRVHS GTYQVTVRIE NMEDKATLVL QVVDKPSPPQ DLRVTDAWGL 1080 NVALEWKPPQ DVGNTELWGY TVQKADKKTM EWFTVLEHYR RTHCVVPELI IGNGYYFRVF 1140 SQNMVGFSDR AATTKEPVFI PRPGITYEPP NYKALDFSEA PSFTQPLVNR SVIAGYTAML 1200 CCAVRGSPKP KISWFKNGLD LGEDARFRMF SKQGVLTLEI RKPCPFDGGI YVCRATNLQG 1260 EARCECRLEV RVPQ 1275 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 8) (view all) | MESH:D006332
; Cardiomegaly MESH:D009202 ; Cardiomyopathies MESH:C566169 ; Cardiomyopathy, Familial Hypertrophic, 4 MESH:D002312 ; Cardiomyopathy, Hypertrophic MESH:D024741 ; Cardiomyopathy, Hypertrophic, Familial MESH:D016757 ; Death, Sudden, Cardiac |
| GWASdb (count: 7) (view all) | rs11570119; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs2290146; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease rs1052373; Type 2 diabetes; type 2 diabetes mellitus rs11570094; Type 2 diabetes; type 2 diabetes mellitus rs2697920; Coronary artery calcification; coronary artery disease rs2856656; Venous thrombosis; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 34) (view all) | 1043 RRVHSGTYQVTVRIE dbPAF
1067 LQVVDKPSPPQDLRV dbPAF 1119 WFTVLEHYRRTHCVV dbPAF 1135 ELIIGNGYYFRVFSQ dbPAF 1136 LIIGNGYYFRVFSQN dbPAF 1167 IPRPGITYEPPNYKA dbPAF |