| Tag | Content |
|---|---|
| UniProt Accession | UBP10_HUMAN; Q14694; |
| Entrez ID | 9100 |
| GenBank Protein ID | NM_001272075.1; NM_005153.2; |
| GenBank Nucleotide ID | NP_001259004.1; NP_005144.2; |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) |
| Gene Name | USP10; KIAA0190 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN(view all) |
| Sequence (Fasta) | MALHSPQYIF GDFSPDEFNQ FFVTPRSSVE LPPYSGTVLC GTQAVDKLPD GQEYQRIEFG 60 VDEVIEPSDT LPRTPSYSIS STLNPQAPEF ILGCTASKIT PDGITKEASY GSIDCQYPGS 120 ALALDGSSNV EAEVLENDGV SGGLGQRERK KKKKRPPGYY SYLKDGGDDS ISTEALVNGH 180 ANSAVPNSVS AEDAEFMGDM PPSVTPRTCN SPQNSTDSVS DIVPDSPFPG ALGSDTRTAG 240 QPEGGPGADF GQSCFPAEAG RDTLSRTAGA QPCVGTDTTE NLGVANGQIL ESSGEGTATN 300 GVELHTTESI DLDPTKPESA SPPADGTGSA SGTLPVSQPK SWASLFHDSK PSSSSPVAYV 360 ETKYSPPAIS PLVSEKQVEV KEGLVPVSED PVAIKIAELL ENVTLIHKPV SLQPRGLINK 420 GNWCYINATL QALVACPPMY HLMKFIPLYS KVQRPCTSTP MIDSFVRLMN EFTNMPVPPK 480 PRQALGDKIV RDIRPGAAFE PTYIYRLLTV NKSSLSEKGR QEDAEEYLGF ILNGLHEEML 540 NLKKLLSPSN EKLTISNGPK NHSVNEEEQE EQGEGSEDEW EQVGPRNKTS VTRQADFVQT 600 PITGIFGGHI RSVVYQQSSK ESATLQPFFT LQLDIQSDKI RTVQDALESL VARESVQGYT 660 TKTKQEVEIS RRVTLEKLPP VLVLHLKRFV YEKTGGCQKL IKNIEYPVDL EISKELLSPG 720 VKNKNFKCHR TYRLFAVVYH HGNSATGGHY TTDVFQIGLN GWLRIDDQTV KVINQYQVVK 780 PTAERTAYLL YYRRVDLL 799 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 29) (view all) | rs8045120; Type 2 diabetes; type 2 diabetes mellitus
rs3764286; Parkinson's disease; Parkinson's disease rs1862794; Type 2 diabetes; type 2 diabetes mellitus rs1862794; Multiple complex diseases; Null rs41422347; Multiple complex diseases; Null rs12149617; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 62) (view all) | 100 GCTASKITPDGITKE dbPAF
105 KITPDGITKEASYGS dbPAF 110 GITKEASYGSIDCQY dbPAF 14 QYIFGDFSPDEFNQF dbPAF 159 KKKRPPGYYSYLKDG dbPAF 160 KKRPPGYYSYLKDGG dbPAF |
| Acetylation (count: 16) (view all) | 350 ASLFHDSKPSSSSPV PLMD
363 PVAYVETKYSPPAIS PLMD 376 ISPLVSEKQVEVKEG PLMD 408 ENVTLIHKPVSLQPR PLMD 47 CGTQAVDKLPDGQEY PLMD 488 PRQALGDKIVRDIRP PLMD |
| Ubiquitination (count: 16) (view all) | 381 SEKQVEVKEGLVPVS PLMD
408 ENVTLIHKPVSLQPR PLMD 451 KFIPLYSKVQRPCTS PLMD 488 PRQALGDKIVRDIRP PLMD 512 YRLLTVNKSSLSEKG PLMD 544 EEMLNLKKLLSPSNE PLMD |
| Malonylation (count: 2) | 693 LKRFVYEKTGGCQKL PLMD
780 INQYQVVKPTAERTA PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |