| Tag | Content |
|---|---|
| UniProt Accession | BECN1_HUMAN; Q14457; |
| Entrez ID | 8678 |
| GenBank Protein ID | NM_001313998.1; NM_001313999.1; NM_001314000.1; NM_003766.4; |
| GenBank Nucleotide ID | NP_001300927.1; NP_001300928.1; NP_001300929.1; NP_003757.1; |
| Protein Name | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] |
| Gene Name | BECN1; GT197 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.;Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. |
| Sequence (Fasta) | MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE 60 ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG 120 DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL 180 QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ 240 LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW 300 NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF 360 WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN 420 SEEQWTKALK FMLTNLKWGL AWVSSQFYNK 451 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 5) | MESH:D003110
; Colonic Neoplasms MESH:D020961 ; Lewy Body Disease MESH:D008175 ; Lung Neoplasms MESH:D009203 ; Myocardial Infarction MESH:D013226 ; Status Epilepticus |
| GWASdb (count: 1) | rs9910698; Depression (quantitative trait); mental depression |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 108 GEASDGGTMENLSRR dbPAF
119 LSRRLKVTGDLFDIM dbPAF 15 NNSTMQVSFVCQRCS dbPAF 229 LDQEEAQYQREYSEF dbPAF 233 EAQYQREYSEFKRQQ dbPAF 234 AQYQREYSEFKRQQL dbPAF |
| Acetylation (count: 1) | 206 EDVEKNRKIVAENLE PLMD |
| Ubiquitination (count: 10) (view all) | 206 EDVEKNRKIVAENLE PLMD
214 IVAENLEKVQAEAER PLMD 237 QREYSEFKRQQLELD PLMD 248 LELDDELKSVENQMR PLMD 26 QRCSQPLKLDTSFKI PLMD 263 YAQTQLDKLKKTNVF PLMD |