Tag | Content |
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UniProt Accession | FAK2_HUMAN; Q14289; |
Entrez ID | 2185 |
GenBank Protein ID | NM_004103.4; NM_173174.2; NM_173175.2; NM_173176.2; XM_005273447.4; XM_011544441.2; XM_017013214.1; |
GenBank Nucleotide ID | NP_004094.3; NP_775266.1; NP_775267.1; NP_775268.1; XP_005273504.1; XP_011542743.1; XP_016868703.1; |
Protein Name | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine |
Gene Name | PTK2B; FAK2; PYK2; RAFTK |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell respons(view all) |
Sequence (Fasta) | MSGVSEPLSR VKLGTLRRPE GPAEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK 60 CTVQTEIREI ITSILLSGRI GPNIRLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC 120 LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC 180 LELRRFFKDM PHNALDKKSN FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS 240 LREEECVMKF FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDAKPTCLA 300 EFKQIRSIRC LPLEEGQAVL QLGIEGAPQA LSIKTSSLAE AENMADLIDG YCRLQGEHQG 360 SLIIHPRKDG EKRNSLPQIP MLNLEARRSH LSESCSIESD IYAEIPDETL RRPGGPQYGI 420 AREDVVLNRI LGEGFFGEVY EGVYTNHKGE KINVAVKTCK KDCTLDNKEK FMSEAVIMKN 480 LDHPHIVKLI GIIEEEPTWI IMELYPYGEL GHYLERNKNS LKVLTLVLYS LQICKAMAYL 540 ESINCVHRDI AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR 600 RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPDLC PPVLYTLMTR 660 CWDYDPSDRP RFTELVCSLS DVYQMEKDIA MEQERNARYR TPKILEPTAF QEPPPKPSRP 720 KYRPPPQTNL LAPKLQFQVP EGLCASSPTL TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR 780 EEDFIQPSSR EEAQQLWEAE KVKMRQILDK QQKQMVEDYQ WLRQEEKSLD PMVYMNDKSP 840 LTPEKEVGYL EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YLNVMELVRA VLELKNELCQ 900 LPPEGYVVVV KNVGLTLRKL IGSVDDLLPS LPSSSRTEIE GTQKLLNKDL AELINKMRLA 960 QQNAVTSLSE ECKRQMLTAS HTLAVDAKNL LDAVDQAKVL ANLAHPPAE |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D008545
; Melanoma MESH:D013226 ; Status Epilepticus MESH:D012878 ; Skin Neoplasms |
DisGeNet (Curated) (count: 4) | C0001973; Alcoholic Intoxication, Chronic
C0025202; melanoma C0037286; Skin Neoplasms C0038220; Status Epilepticus |
GWASdb (count: 17) (view all) | rs7833348; Major depressive disorder; major depressive disorder
rs28834970; Alzheimer's disease (late onset); Alzheimer's disease rs4534095; Urinary metabolites; kidney disease rs10097651; Urinary metabolites; kidney disease rs755951; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder rs12679874; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder |
PTM | Modification Sites |
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Phosphorylation (count: 55) (view all) | 135 RYDLQIRYLPEDFME dbPAF
149 ESLKEDRTTLLYFYQ dbPAF 15 LSRVKLGTLRRPEGP dbPAF 150 SLKEDRTTLLYFYQQ dbPAF 153 EDRTTLLYFYQQLRN dbPAF 155 RTTLLYFYQQLRNDY dbPAF |
Acetylation (count: 2) | 564 VASPECVKLGDFGLS PLMD
973 TSLSEECKRQMLTAS PLMD |
Ubiquitination (count: 4) | 188 LELRRFFKDMPHNAL PLMD
295 QLTSQDAKPTCLAEF PLMD 581 IEDEDYYKASVTRLP PLMD 944 TEIEGTQKLLNKDLA PLMD |