Q14289

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession FAK2_HUMAN; Q14289;
Entrez ID 2185
GenBank Protein ID NM_004103.4; NM_173174.2; NM_173175.2; NM_173176.2; XM_005273447.4; XM_011544441.2; XM_017013214.1;
GenBank Nucleotide ID NP_004094.3; NP_775266.1; NP_775267.1; NP_775268.1; XP_005273504.1; XP_011542743.1; XP_016868703.1;
Protein Name Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine
Gene Name PTK2B; FAK2; PYK2; RAFTK
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionNon-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell respons(view all)
Sequence
(Fasta)
MSGVSEPLSR VKLGTLRRPE GPAEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK 60
CTVQTEIREI ITSILLSGRI GPNIRLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC 120
LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC 180
LELRRFFKDM PHNALDKKSN FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS 240
LREEECVMKF FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDAKPTCLA 300
EFKQIRSIRC LPLEEGQAVL QLGIEGAPQA LSIKTSSLAE AENMADLIDG YCRLQGEHQG 360
SLIIHPRKDG EKRNSLPQIP MLNLEARRSH LSESCSIESD IYAEIPDETL RRPGGPQYGI 420
AREDVVLNRI LGEGFFGEVY EGVYTNHKGE KINVAVKTCK KDCTLDNKEK FMSEAVIMKN 480
LDHPHIVKLI GIIEEEPTWI IMELYPYGEL GHYLERNKNS LKVLTLVLYS LQICKAMAYL 540
ESINCVHRDI AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR 600
RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPDLC PPVLYTLMTR 660
CWDYDPSDRP RFTELVCSLS DVYQMEKDIA MEQERNARYR TPKILEPTAF QEPPPKPSRP 720
KYRPPPQTNL LAPKLQFQVP EGLCASSPTL TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR 780
EEDFIQPSSR EEAQQLWEAE KVKMRQILDK QQKQMVEDYQ WLRQEEKSLD PMVYMNDKSP 840
LTPEKEVGYL EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YLNVMELVRA VLELKNELCQ 900
LPPEGYVVVV KNVGLTLRKL IGSVDDLLPS LPSSSRTEIE GTQKLLNKDL AELINKMRLA 960
QQNAVTSLSE ECKRQMLTAS HTLAVDAKNL LDAVDQAKVL ANLAHPPAE

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationProstate cancer/carcinoma/adenocarcinomatumor tissueUY40222307624
[Reference]: Tyrosine Phosphorylation Is Increased in Clinical Castration-Resistant Prostate Cancer Samples
2Tyrosine PhosphorylationProstate cancer/carcinoma/adenocarcinomatumor tissueUY57922307624
[Reference]: Tyrosine Phosphorylation Is Increased in Clinical Castration-Resistant Prostate Cancer Samples
3Tyrosine PhosphorylationProstate cancer/carcinoma/adenocarcinomatumor tissueUY84922307624
[Reference]: Tyrosine Phosphorylation Is Increased in Clinical Castration-Resistant Prostate Cancer Samples
4Tyrosine PhosphorylationNon-small cell lung cancer/carcinomacell lineUY88123922106
[Reference]: The levels of Pyk2 mRNA, total protein, and its phosphorylated form pY881 were higher in lung cancer lesions than in the paired noncancerous tissues

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)
MESH:D008545 ; Melanoma
MESH:D013226 ; Status Epilepticus
MESH:D012878 ; Skin Neoplasms
DisGeNet (Curated)
(count: 4)
C0001973; Alcoholic Intoxication, Chronic
C0025202; melanoma
C0037286; Skin Neoplasms
C0038220; Status Epilepticus
GWASdb
(count: 17)
(view all)
rs7833348; Major depressive disorder; major depressive disorder
rs28834970; Alzheimer's disease (late onset); Alzheimer's disease
rs4534095; Urinary metabolites; kidney disease
rs10097651; Urinary metabolites; kidney disease
rs755951; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder
rs12679874; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 55)
(view all)
135       RYDLQIRYLPEDFME     dbPAF
149       ESLKEDRTTLLYFYQ     dbPAF
15        LSRVKLGTLRRPEGP     dbPAF
150       SLKEDRTTLLYFYQQ     dbPAF
153       EDRTTLLYFYQQLRN     dbPAF
155       RTTLLYFYQQLRNDY     dbPAF
Acetylation
(count: 2)
564       VASPECVKLGDFGLS     PLMD
973       TSLSEECKRQMLTAS     PLMD
Ubiquitination
(count: 4)
188       LELRRFFKDMPHNAL     PLMD
295       QLTSQDAKPTCLAEF     PLMD
581       IEDEDYYKASVTRLP     PLMD
944       TEIEGTQKLLNKDLA     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
E7ESA6Q14289HPRD
G3V0F8Q14289HPRD
O00562Q14289HPRD
O15259Q14289HPRD
O15530Q14289HPRD
O43150Q14289HPRD
O43281Q14289HPRD
O43294Q14289HPRD
O60674Q14289HPRD
O60711Q14289HPRD
O94875Q14289HPRD
O95886Q14289HPRD
P00533Q14289HPRD; IntAct
P04626Q14289HPRD
P05106Q14289HPRD
P05107Q14289HPRD
P06239Q14289HPRD
P06241Q14289HPRD
P06396Q14289HPRD
P07948Q14289HPRD
P11166Q14289HPRD
P12931Q14289HPRD
P15498Q14289HPRD
P16389Q14289HPRD
P16871Q14289HPRD
P17948Q14289HPRD
P20936Q14289HPRD
P21802Q14289HPRD
P21860Q14289HPRD
P22607Q14289HPRD
P22681Q14289HPRD
P23458Q14289HPRD
P27986Q14289HPRD
P29353Q14289HPRD
P37840Q14289HPRD
P40763Q14289HPRD
P42679Q14289HPRD
P43121Q14289HPRD
P43403Q14289HPRD
P43405Q14289HPRD
P46108Q14289HPRD
P49023Q14289HPRD
P51681Q14289HPRD
P52333Q14289HPRD
P56945Q14289HPRD
P62993Q14289HPRD
P78352Q14289HPRD
Q00005Q14289IntAct
Q01844Q14289HPRD
Q05209Q14289HPRD
Q05655Q14289HPRD
Q06124Q14289HPRD
Q12879Q14289HPRD
Q13017Q14289HPRD
Q14289Q14289HPRD
Q14289Q14344HPRD
Q14289Q14511HPRD
Q14289Q5T5U3HPRD
Q14289Q7L0Q8IntAct
Q14289Q8N5H7HPRD
Q14289Q8TDY2HPRD
Q14289Q8WUM4HPRD; MINT
Q14289Q92796HPRD
Q14289Q9BZ71HPRD
Q14289Q9BZ72HPRD
Q14289Q9UKX2HPRD
Q14289Q9ULH1HPRD;MINT
Q14289Q9ULZ2HPRD
Q14289Q9Y490HPRD
Q14289Q9Y6R4HPRD; MINT