Tag | Content |
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UniProt Accession | DCTN1_HUMAN; Q14203; |
Entrez ID | 1639 |
GenBank Protein ID | NM_001135040.2; NM_001135041.2; NM_001190836.1; NM_001190837.1; NM_004082.4; NM_023019.3; |
GenBank Nucleotide ID | NP_001128512.1; NP_001128513.1; NP_001177765.1; NP_001177766.1; NP_004073.2; NP_075408.1; |
Protein Name | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) |
Gene Name | DCTN1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility al(view all) |
Sequence (Fasta) | MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV 60 ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE 120 GTDTTAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGASSSLGPS GSASAGELSS 180 SEPSTPAQTP LAAPIIPTPV LTSPGAVPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRAE 240 DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT 300 ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL 360 KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE 420 STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE 480 TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA 540 SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG 600 GDHDCVLVLL LMPRLICKAE LIRKQAQEKF ELSENCSERP GLRGAAGEQL SFAAGLVYSL 660 SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL 720 TKAIKYYQHL YSIHLAEQPE DCTMQLADHI KFTQSALDCM SVEVGRLRAF LQGGQEATDI 780 ALLLRDLETS CSDIRQFCKK IRRRMPGTDA PGIPAALAFG PQVSDTLLDC RKHLTWVVAV 840 LQEVAAAAAQ LIAPLAENEG LLVAALEELA FKASEQIYGT PSSSPYECLR QSCNILISTM 900 NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK 960 IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLEE TQALLRKKEK EFEETMDALQ 1020 ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEQQR GAIPGQAPGS 1080 VPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG 1140 SELPAGALYR KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE 1200 KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGFGQRH 1260 RLVLTQEQLH QLHSRLIS 1279 |
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Database | Annotation |
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Cancer Gene Census | inflammatory myofibroblastic tumour, Spitzoid tumour |
CTD (Curated) (count: 6) | MESH:C531617
; Amyotrophic lateral sclerosis 1 MESH:D007040 ; Hypoventilation MESH:D019964 ; Mood Disorders MESH:C564362 ; Neuronopathy, Distal Hereditary Motor, Type Viib MESH:D020734 ; Parkinsonian Disorders MESH:C566822 ; Perry Syndrome |
DisGeNet (Curated) (count: 65) (view all) | C0002736; Amyotrophic Lateral Sclerosis
C0003467; Anxiety C0011581; Depressive disorder C0013362; Dysarthria C0013404; Dyspnea C0015672; Fatigue |
HGMD (count: 11) (view all) | CM030648; Motor neuron disease, lower; Missense/nonsense
CM090397; Perry syndrome; Missense/nonsense CM090398; Perry syndrome; Missense/nonsense CM090396; Perry syndrome; Missense/nonsense CM090399; Perry syndrome; Missense/nonsense CM090400; Perry syndrome; Missense/nonsense |
PTM | Modification Sites |
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Phosphorylation (count: 30) (view all) | 1001 VQTRLEETQALLRKK dbPAF
103 VFEDGADTTSPETPD dbPAF 104 FEDGADTTSPETPDS dbPAF 1041 KQRLNSQSKRTIEGL dbPAF 105 EDGADTTSPETPDSS dbPAF 108 ADTTSPETPDSSASK dbPAF |
Acetylation (count: 6) | 230 QVRDLEEKLETLRLK PLMD
262 LEQVQEWKSKMQEQQ PLMD 38 SRVEVIGKGHRGTVA PLMD 390 SEKQEHVKLQKLMEK PLMD 393 QEHVKLQKLMEKKNQ PLMD 725 EPLTKAIKYYQHLYS PLMD |
Ubiquitination (count: 25) (view all) | 1034 EAEKAELKQRLNSQS PLMD
1115 QHENSILKGAQMKAS PLMD 1120 ILKGAQMKASLASLP PLMD 1133 LPPLHVAKLSHEGPG PLMD 115 TPDSSASKVLKREGT PLMD 1151 PAGALYRKTSQLLET PLMD |
Sumoylation (count: 1) | 1203 SDTVEKLKDEVLKET PLMD |
Malonylation (count: 6) | 398 LQKLMEKKNQELEVV PLMD
453 RNLNLEEKVRELRET PLMD 518 ADYQQTIKKYRQLTA PLMD 567 AETKAHAKAIEMELR PLMD 77 DGTVQGRKYFTCDEG PLMD 960 KELKKSLKIKGEELS PLMD |
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