Q14203

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession DCTN1_HUMAN; Q14203;
Entrez ID 1639
GenBank Protein ID NM_001135040.2; NM_001135041.2; NM_001190836.1; NM_001190837.1; NM_004082.4; NM_023019.3;
GenBank Nucleotide ID NP_001128512.1; NP_001128513.1; NP_001177765.1; NP_001177766.1; NP_004073.2; NP_075408.1;
Protein Name Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene Name DCTN1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPlays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility al(view all)
Sequence
(Fasta)
MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV 60
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE 120
GTDTTAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGASSSLGPS GSASAGELSS 180
SEPSTPAQTP LAAPIIPTPV LTSPGAVPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRAE 240
DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT 300
ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL 360
KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE 420
STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE 480
TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA 540
SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG 600
GDHDCVLVLL LMPRLICKAE LIRKQAQEKF ELSENCSERP GLRGAAGEQL SFAAGLVYSL 660
SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL 720
TKAIKYYQHL YSIHLAEQPE DCTMQLADHI KFTQSALDCM SVEVGRLRAF LQGGQEATDI 780
ALLLRDLETS CSDIRQFCKK IRRRMPGTDA PGIPAALAFG PQVSDTLLDC RKHLTWVVAV 840
LQEVAAAAAQ LIAPLAENEG LLVAALEELA FKASEQIYGT PSSSPYECLR QSCNILISTM 900
NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK 960
IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLEE TQALLRKKEK EFEETMDALQ 1020
ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEQQR GAIPGQAPGS 1080
VPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG 1140
SELPAGALYR KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE 1200
KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGFGQRH 1260
RLVLTQEQLH QLHSRLIS 1279

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationProstate cancer/carcinoma/adenocarcinomaPC-3 cell linePS17923661607
[Reference]: Plk1 phosphorylation of p150Glued and CLIP-170 prevents paclitaxel-induced apoptosi

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
inflammatory myofibroblastic tumour, Spitzoid tumour
CTD (Curated)
(count: 6)
MESH:C531617 ; Amyotrophic lateral sclerosis 1
MESH:D007040 ; Hypoventilation
MESH:D019964 ; Mood Disorders
MESH:C564362 ; Neuronopathy, Distal Hereditary Motor, Type Viib
MESH:D020734 ; Parkinsonian Disorders
MESH:C566822 ; Perry Syndrome
DisGeNet (Curated)
(count: 65)
(view all)
C0002736; Amyotrophic Lateral Sclerosis
C0003467; Anxiety
C0011581; Depressive disorder
C0013362; Dysarthria
C0013404; Dyspnea
C0015672; Fatigue
HGMD
(count: 11)
(view all)
CM030648; Motor neuron disease, lower; Missense/nonsense
CM090397; Perry syndrome; Missense/nonsense
CM090398; Perry syndrome; Missense/nonsense
CM090396; Perry syndrome; Missense/nonsense
CM090399; Perry syndrome; Missense/nonsense
CM090400; Perry syndrome; Missense/nonsense

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 30)
(view all)
1001      VQTRLEETQALLRKK     dbPAF
103       VFEDGADTTSPETPD     dbPAF
104       FEDGADTTSPETPDS     dbPAF
1041      KQRLNSQSKRTIEGL     dbPAF
105       EDGADTTSPETPDSS     dbPAF
108       ADTTSPETPDSSASK     dbPAF
Acetylation
(count: 6)
230       QVRDLEEKLETLRLK     PLMD
262       LEQVQEWKSKMQEQQ     PLMD
38        SRVEVIGKGHRGTVA     PLMD
390       SEKQEHVKLQKLMEK     PLMD
393       QEHVKLQKLMEKKNQ     PLMD
725       EPLTKAIKYYQHLYS     PLMD
Ubiquitination
(count: 25)
(view all)
1034      EAEKAELKQRLNSQS     PLMD
1115      QHENSILKGAQMKAS     PLMD
1120      ILKGAQMKASLASLP     PLMD
1133      LPPLHVAKLSHEGPG     PLMD
115       TPDSSASKVLKREGT     PLMD
1151      PAGALYRKTSQLLET     PLMD
Sumoylation
(count: 1)
1203      SDTVEKLKDEVLKET     PLMD
Malonylation
(count: 6)
398       LQKLMEKKNQELEVV     PLMD
453       RNLNLEEKVRELRET     PLMD
518       ADYQQTIKKYRQLTA     PLMD
567       AETKAHAKAIEMELR     PLMD
77        DGTVQGRKYFTCDEG     PLMD
960       KELKKSLKIKGEELS     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
E9PE28Q14203HPRD
E9PHM6Q14203HPRD
F5H0P3Q14203MINT
H0YBT0Q14203IntAct
O14576Q14203MINT
O14593Q14203IntAct
O15020Q14203HPRD
O60925Q14203MINT
O75935Q14203HPRD
O76071Q14203IntAct
P08670Q14203HPRD
P10636Q14203MINT
P18669Q14203HPRD; IntAct; MINT
P20340Q14203MINT;HPRD
P27695Q14203HPRD
P30622Q14203HPRD
P31749Q14203MINT
P40337Q14203IntAct
P42025Q14203HPRD; IntAct
P42224Q14203IntAct
P42574Q14203HPRD
P42575Q14203HPRD
P43034Q14203HPRD
P43360Q14203IntAct
P46734Q14203HPRD
P49662Q14203IntAct
P49841Q14203HPRD
P51955Q14203MINT
P52564Q14203HPRD
P52732Q14203HPRD
P54257Q14203HPRD; MINT
P55210Q14203HPRD
P61163Q14203HPRD
P62136Q14203IntAct
P62330Q14203IntAct
P62993Q14203HPRD
Q13409Q14203HPRD
Q14203Q14203HPRD
Q14203Q15436HPRD
Q14203Q15691HPRD
Q14203Q16543MINT
Q14203Q6ZP65MINT
Q14203Q6ZU52MINT
Q14203Q7L1Q6IntAct
Q14203Q8NFJ9IntAct
Q14203Q8TCX1MINT
Q14203Q8TD16HPRD; MINT
Q14203Q96G01HPRD; MINT
Q14203Q96KM6MINT
Q14203Q96RK4IntAct
Q14203Q99551IntAct
Q14203Q9H8T0IntAct
Q14203Q9NRI5IntAct
Q14203Q9Y2Q3IntAct