| Tag | Content |
|---|---|
| UniProt Accession | DPYL1_HUMAN; Q14194; |
| Entrez ID | 1400 |
| GenBank Protein ID | NM_001014809.2; NM_001288661.1; NM_001288662.1; NM_001313.4; |
| GenBank Nucleotide ID | NP_001014809.1; NP_001275590.1; NP_001275591.1; NP_001304.1; |
| Protein Name | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Unc-33-like phosphoprotein 3) (ULIP-3) |
| Gene Name | CRMP1; DPYSL1; ULIP3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. |
| Sequence (Fasta) | MSYQGKKSIP HITSDRLLIK GGRIINDDQS LYADVYLEDG LIKQIGENLI VPGGVKTIEA 60 NGRMVIPGGI DVNTYLQKPS QGMTAADDFF QGTRAALVGG TTMIIDHVVP EPGSSLLTSF 120 EKWHEAADTK SCCDYSLHVD ITSWYDGVRE ELEVLVQDKG VNSFQVYMAY KDVYQMSDSQ 180 LYEAFTFLKG LGAVILVHAE NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI 240 TIAGRINCPV YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA 300 FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL IPEGVNGIEE 360 RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR IAVGSDADVV IWDPDKLKTI 420 TAKSHKSAVE YNIFEGMECH GSPLVVISQG KIVFEDGNIN VNKGMGRFIP RKAFPEHLYQ 480 RVKIRNKVFG LQGVSRGMYD GPVYEVPATP KYATPAPSAK SSPSKHQPPP IRNLHQSNFS 540 LSGAQIDDNN PRRTGHRIVA PPGGRSNITS LG 573 |
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| Database | Annotation |
|---|---|
| DisGeNet (Curated) (count: 2) | C0036341; Schizophrenia
C3178803; Social Anhedonia |
| GWASdb (count: 16) (view all) | rs3821936; Multiple complex diseases; Null
rs6820236; Multiple complex diseases; Null rs12331; Multiple complex diseases; Null rs7654446; Alcohol dependence; alcohol dependence rs16837723; Blood pressure; hypertension rs16837723; Intraocular pressure; glaucoma |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 24) (view all) | 101 RAALVGGTTMIIDHV dbPAF
102 AALVGGTTMIIDHVV dbPAF 2 ******MSYQGKKSI dbPAF 253 INCPVYITKVMSKSA dbPAF 257 VYITKVMSKSAADII dbPAF 259 ITKVMSKSAADIIAL dbPAF |
| Acetylation (count: 1) | 345 TAQKAVGKDNFTLIP PLMD |
| Ubiquitination (count: 2) | 293 DGTHYWSKNWAKAAA PLMD
345 TAQKAVGKDNFTLIP PLMD |