Q14185

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	DOCK1_HUMAN; Q14185;
Entrez ID	1793
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene Name	DOCK1
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). Functional Description Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).
Sequence (Fasta)	MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT LRKKSKKGIF 60 PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS TIWRQLYVQD NREMFRSVRH 120 MIYDLIEWRS QILSGTLPQD ELKELKKKVT AKIDYGNRIL DLDLVVRDED GNILDPELTS 180 TISLFRAHEI ASKQVEERLQ EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA 240 EVLMSLYDPV ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 300 IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP FQPVAGENDF 360 LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP HLVDRTTAVA RKTGFPEIIM 420 PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV TVSVYDEDGK RLEHVIFPGA GDEAISEYKS 480 VIYYQVKQPR WFETVKVAIP IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD 540 GTTLRDGEHD LIVYKAEAKK LEDAATYLSL PSTKAELEEK GHSATGKSMQ SLGSCTISKD 600 SFQISTLVCS TKLTQNVDLL GLLKWRSNTS LLQQNLRQLM KVDGGEVVKF LQDTLDALFN 660 IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET YIKKHFSATL AYTKLTKVLK 720 NYVDGAEKPG VNEQLYKAMK ALESIFKFIV RSRILFNQLY ENKGEADFVE SLLQLFRSIN 780 DMMSSMSDQT VRVKGAALKY LPTIVNDVKL VFDPKELSKM FTEFILNVPM GLLTIQKLYC 840 LIEIVHSDLF TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSHILEV LYRKDVGPTQ 900 RHVQIIMEKL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL IKTFGKMRTD 960 VVDFLMETFI MFKNLIGKNV YPFDWVIMNM VQNKVFLRAI NQYADMLNKK FLDQANFELQ 1020 LWNNYFHLAV AFLTQESLQL ENFSSAKRAK ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF 1080 IPEMVGPILE MTLIPETELR KATIPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR 1140 GDEQYKVLFD KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKENRMSCT 1200 VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS EDVCVAHLTQ 1260 RDGYQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL AEQYENEMFD YEQLSELLKK 1320 QAQFYENIVK VIRPKPDYFA VGYYGQGFPT FLRGKVFIYR GKEYERREDF EARLLTQFPN 1380 AEKMKTTSPP GDDIKNSPGQ YIQCFTVKPK LDLPPKFHRP VSEQIVSFYR VNEVQRFEYS 1440 RPIRKGEKNP DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 1500 NDKINSMVQQ HLDDPSLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY LQEHPEAHEK 1560 IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC FKQLKEKVEK EYGVRIMPSS 1620 LDDRRGSRPR SMVRSFTMPS SSRPLSVASV SSLSSDSTPS RPGSDGFALE PLLPKKMHSR 1680 SQDKLDKDDL EKEKKDKKKE KRNSKHQEIF EKEFKPTDIS LQQSEAVILS ETISPLRPQR 1740 PKSQVMNVIG SERRFSVSPS SPSSQQTPPP VTPRAKLSFS MQSSLELNGM TGADVADVPP 1800 PLPLKGSVAD YGNLMENQDL LGSPTPPPPP PHQRHLPPPL PSKTPPPPPP KTTRKQASVD 1860 SGIVQ 1866 Fasta Sequence >Q14185\|DOCK1\|Homo sapiens (Human) MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVTDIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMMSSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIGNFVACMTAILRQMEDYHYAHLIKTFGKMRTDVVDFLMETFIMFKNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGRGDEQYKVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWSEDVCVAHLTQRDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRAKLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVDSGIVQ

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Tyrosine Phosphorylation	Glioblastoma		P	Y722	22323579
1	[Reference]: Finally, phosphorylated Dock180(Y722) is coexpressed with EGFRvIII and phosphorylated Src(Y418) in clinical specimens, and such coexpression correlates with an extremely poor survival in glioblastoma patients.
2	Serine Phosphorylation	Glioblastoma		C	S1250	23728337
2	[Reference]: EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 1)	MESH:D019966 ; Substance-Related Disorders
DisGeNet (Curated) (count: 1)	C0236969; Substance-Related Disorders
GWASdb (count: 47) (view all)	rs9733352; Apolipoprotein Levels; lipid metabolism disorder rs10741150; Premature ovarian failure; premature ovarian failure rs10741150; Hypertension (essential hypertension); hypertension rs2275540; Response to cytidine analogues (gemcitabine); cancer rs2275540; Response to cytadine analogues (cytosine arabinoside); cancer rs9418753; Response to cytidine analogues (gemcitabine); cancer rs7912111; Stroke; cerebrovascular disease rs4751175; Urinary metabolites; kidney disease rs2050812; Smoking quantity; nicotine dependence rs4635002; Urinary metabolites; kidney disease rs9418834; Urinary metabolites; kidney disease rs12264769; Multiple complex diseases; Null rs928572; Multiple complex diseases; Null rs7923977; Cognitive test performance; cognitive disorder rs2489401; Multiple complex diseases; Null rs1060561; Coronary Artery Disease; coronary artery disease rs2486968; Cognitive test performance; cognitive disorder rs2483853; Response to statin therapy; coronary artery disease\|myopathy\|atherosclerosis rs2483865; Iron levels; iron metabolism disease rs2050305; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs10829607; Oral cancers (chewing tobacco related); squamous cell carcinoma\|mouth disease rs11819364; Social communication problems; autism spectrum disorder rs11016909; Multiple complex diseases; Null rs2498947; Stroke; cerebrovascular disease rs11017083; Height (Pygmy height); Null rs2720972; Coronary heart disease; coronary artery disease rs2720967; Coronary heart disease; coronary artery disease rs1006217; Prostate cancer mortality; prostate cancer rs1006217; Salmonella-induced pyroptosis; Null rs12570609; Alzheimer's disease; Alzheimer's disease rs7914006; Alzheimer's disease; Alzheimer's disease rs10829893; Multiple complex diseases; Null rs2296630; Response to mTOR inhibitor (everolimus); renal cell carcinoma\|breast cancer\|non-small cell lung carcinoma\|endometrial carcinoma\|glioblastoma multiforme\|mantle cell lymphoma rs2229599; Multiple complex diseases; Null rs2229599; Coronary heart disease; coronary artery disease rs7895671; Magnesium levels; disorder of magnesium metabolism\|magnesium deficiency rs7920698; Magnesium levels; disorder of magnesium metabolism\|magnesium deficiency rs11017990; Alzheimer's disease; Alzheimer's disease rs1078336; Post-operative nausea and vomiting; Null rs1078336; White matter integrity; bipolar disorder\|brain disease rs10765093; Weight; obesity rs11018077; Alcohol dependence; alcohol dependence rs7095670; Magnesium levels; disorder of magnesium metabolism\|magnesium deficiency rs1931702; Cognitive test performance; cognitive disorder rs10830067; Urinary metabolites; kidney disease rs11018104; Body mass index; obesity rs7904011; Alzheimer's disease; Alzheimer's disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 43) (view all)	100 TTTLREWSTIWRQLY dbPAF 101 TTLREWSTIWRQLYV dbPAF 107 STIWRQLYVQDNREM dbPAF 1198 ENKENRMSCTVNVLN dbPAF 1200 KENRMSCTVNVLNFY dbPAF 1250 HAKLLKWSEDVCVAH dbPAF 1304 GKELAEQYENEMFDY dbPAF 150 KELKKKVTAKIDYGN dbPAF 155 KVTAKIDYGNRILDL dbPAF 1612 KEKVEKEYGVRIMPS dbPAF 1627 SLDDRRGSRPRSMVR dbPAF 1637 RSMVRSFTMPSSSRP dbPAF 1642 SFTMPSSSRPLSVAS dbPAF 1664 STPSRPGSDGFALEP dbPAF 1681 PKKMHSRSQDKLDKD dbPAF 1704 KKKEKRNSKHQEIFE dbPAF 1743 LRPQRPKSQVMNVIG dbPAF 1751 QVMNVIGSERRFSVS dbPAF 1756 IGSERRFSVSPSSPS dbPAF 1758 SERRFSVSPSSPSSQ dbPAF 1760 RRFSVSPSSPSSQQT dbPAF 1763 SVSPSSPSSQQTPPP dbPAF 1772 QQTPPPVTPRAKLSF dbPAF 1807 PPLPLKGSVADYGNL dbPAF 1811 LKGSVADYGNLMENQ dbPAF 1823 ENQDLLGSPTPPPPP dbPAF 1825 QDLLGSPTPPPPPPH dbPAF 1842 HLPPPLPSKTPPPPP dbPAF 1844 PPPLPSKTPPPPPPK dbPAF 1858 KTTRKQASVDSGIVQ dbPAF 204 ERLQEEKSQKQNIDI dbPAF 265 NYLVRWSSSGLPKDI dbPAF 314 MELRDNNTRKLTSGL dbPAF 319 NNTRKLTSGLRRPFG dbPAF 478 GDEAISEYKSVIYYQ dbPAF 483 SEYKSVIYYQVKQPR dbPAF 583 ELEEKGHSATGKSMQ dbPAF 591 ATGKSMQSLGSCTIS dbPAF 760 RILFNQLYENKGEAD dbPAF 784 RSINDMMSSMSDQTV dbPAF 800 VKGAALKYLPTIVND dbPAF 803 AALKYLPTIVNDVKL dbPAF 818 VFDPKELSKMFTEFI dbPAF
Acetylation (count: 1)	1054 KRAKILNKYGDMRRQ PLMD
Ubiquitination (count: 1)	799 RVKGAALKYLPTIVN PLMD
Glycation (count: 1)	253 LYDPVESKFISENYL PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O15084	Q14185	MINT
O43639	Q14185	HPRD; MINT
P06241	Q14185	IntAct; MINT
P12931	Q14185	IntAct; MINT
P16333	Q14185	IntAct
P46108	Q14185	HPRD; DIP; IntAct
P56945	Q14185	HPRD
P62993	Q14185	IntAct
P63000	Q14185	IntAct; MINT;HPRD
P84095	Q14185	HPRD; IntAct
Q14185	Q14185	MINT
Q14185	Q15744	MINT
Q14185	Q92556	HPRD; IntAct; MINT
Q14185	Q96JJ3	HPRD
Q14185	Q9GZQ8	IntAct
Q14185	Q9Y6W5	HPRD