Tag | Content |
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UniProt Accession | IKKE_HUMAN; Q14164; |
Entrez ID | 9641 |
GenBank Protein ID | NM_001193321.1; NM_001193322.1; NM_014002.3; XM_005273356.2; |
GenBank Nucleotide ID | NP_001180250.1; NP_001180251.1; NP_054721.1; XP_005273413.1; |
Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) |
Gene Name | IKBKE; IKKE; IKKI; KIAA0151 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to tra(view all) |
Sequence (Fasta) | MQSTANYLWH TDDLLGQGAT ASVYKARNKK SGELVAVKVF NTTSYLRPRE VQVREFEVLR 60 KLNHQNIVKL FAVEETGGSR QKVLVMEYCS SGSLLSVLES PENAFGLPED EFLVVLRCVV 120 AGMNHLRENG IVHRDIKPGN IMRLVGEEGQ SIYKLTDFGA ARELDDDEKF VSVYGTEEYL 180 HPDMYERAVL RKPQQKAFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEIMYRITTE 240 KPAGAIAGAQ RRENGPLEWS YTLPITCQLS LGLQSQLVPI LANILEVEQA KCWGFDQFFA 300 ETSDILQRVV VHVFSLSQAV LHHIYIHAHN TIAIFQEAVH KQTSVAPRHQ EYLFEGHLCV 360 LEPSVSAQHI AHTTASSPLT LFSTAIPKGL AFRDPALDVP KFVPKVDLQA DYNTAKGVLG 420 AGYQALRLAR ALLDGQELMF RGLHWVMEVL QATCRRTLEV ARTSLLYLSS SLGTERFSSV 480 AGTPEIQELK AAAELRSRLR TLAEVLSRCS QNITETQESL SSLNRELVKS RDQVHEDRSI 540 QQIQCCLDKM NFIYKQFKKS RMRPGLGYNE EQIHKLDKVN FSHLAKRLLQ VFQEECVQKY 600 QASLVTHGKR MRVVHETRNH LRLVGCSVAA CNTEAQGVQE SLSKLLEELS HQLLQDRAKG 660 AQASPPPIAP YPSPTRKDLL LHMQELCEGM KLLASDLLDN NRIIERLNRV PAPPDV 717 |
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Database | Annotation |
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GWASdb (count: 5) | rs41303986; Taste perception; sensory system disease
rs2297546; Parkinson's disease (age of onset); Parkinson's disease rs11118087; Coronary artery calcification; coronary artery disease rs944775; Celiac disease; celiac disease rs15672; Celiac disease; celiac disease |
PTM | Modification Sites |
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Phosphorylation (count: 12) (view all) | 172 DDDEKFVSVYGTEEY dbPAF
179 SVYGTEEYLHPDMYE dbPAF 463 RTLEVARTSLLYLSS dbPAF 464 TLEVARTSLLYLSSS dbPAF 474 YLSSSLGTERFSSVA dbPAF 479 LGTERFSSVAGTPEI dbPAF |
Ubiquitination (count: 11) (view all) | 137 GIVHRDIKPGNIMRL PLMD
154 EEGQSIYKLTDFGAA PLMD 231 FGGPRRNKEIMYRIT PLMD 241 MYRITTEKPAGAIAG PLMD 25 GATASVYKARNKKSG PLMD 401 DPALDVPKFVPKVDL PLMD |
Sumoylation (count: 1) | 231 FGGPRRNKEIMYRIT PLMD |