Q13887

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession KLF5_HUMAN; Q13887;
Entrez ID 688
GenBank Protein ID NM_001286818.1; NM_001730.4;
GenBank Nucleotide ID NP_001273747.1; NP_001721.2;
Protein Name Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)
Gene Name KLF5; BTEB2; CKLF; IKLF
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscription factor that binds to GC box promoter elements. Activates the transcription of these genes.
Sequence
(Fasta)
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA 60
QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV 120
DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP 180
APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP 240
SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 300
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN 360
RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL 420
TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN 458

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationBreast cancer/tumor/carcinomaP20484041
[Reference]: The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation
2UbiquitinationProstate cancer/carcinoma/adenocarcinomaU15735697
[Reference]: These results suggest that KLF5 protein is degraded at least in part through ubiquitination-proteasome pathway, which may have become hyperactive for KLF5 in cancer cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)
MESH:C538231 ; Adenocarcinoma of lung
MESH:D002294 ; Carcinoma, Squamous Cell
MESH:D058426 ; Neointima
MESH:D010190 ; Pancreatic Neoplasms
GWASdb
(count: 2)
rs7998378; Liver disease in chronic hepatitis B virus infection; hepatitis B|liver disease
rs3782933; Acute lung injury; lung disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 11)
(view all)
116       HKKYRRDSASVVDQF     dbPAF
153       LRTGLYKSQRPCVTH     dbPAF
303       QATYFPPSPPSSEPG     dbPAF
323       AEMLQNLTPPPSYAA     dbPAF
346       HNPNLPTTLPVNSQN     dbPAF
363       PVRYNRRSNPDLEKR     dbPAF
Acetylation
(count: 3)
31        EPVFAQLKPVLGAAN     PLMD
335       YAATIASKLAIHNPN     PLMD
369       RSNPDLEKRRIHYCD     PLMD
Ubiquitination
(count: 3)
110       VPIIPEHKKYRRDSA     PLMD
31        EPVFAQLKPVLGAAN     PLMD
52        LFPGEELKHAHHRPQ     PLMD
Sumoylation
(count: 4)
110       VPIIPEHKKYRRDSA     PLMD
162       RPCVTHIKTEPVAIF     PLMD
209       EVNNIFIKQELPTPD     PLMD
52        LFPGEELKHAHHRPQ     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource