Q13769

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession THOC5_HUMAN; Q13769;
Entrez ID 8563
GenBank Protein ID NM_001002877.1; NM_001002878.1; NM_001002879.1; NM_003678.4;
GenBank Nucleotide ID NP_001002877.1; NP_001002878.1; NP_001002879.1; NP_003669.4;
Protein Name THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)
Gene Name THOC5; C22orf19; KIAA0983
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionActs as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex i(view all)
Sequence
(Fasta)		MSSESSKKRK PKVIRSDGAP AEGKRNRSDT EQEGKYYSEE AEVDLRDPGR DYELYKYTCQ 60
ELQRLMAEIQ DLKSRGGKDV AIEIEERRIQ SCVHFMTLKK LNRLAHIRLK KGRDQTHEAK 120
QKVDAYHLQL QNLLYEVMHL QKEITKCLEF KSKHEEIDLV SLEEFYKEAP PDISKAEVTM 180
GDPHQQTLAR LDWELEQRKR LAEKYRECLS NKEKILKEIE VKKEYLSSLQ PRLNSIMQAS 240
LPVQEYLFMP FDQAHKQYET ARHLPPPLYV LFVQATAYGQ ACDKTLSVAI EGSVDEAKAL 300
FKPPEDSQDD ESDSDAEEEQ TTKRRRPTLG VQLDDKRKEM LKRHPLSVML DLKCKDDSVL 360
HLTFYYLMNL NIMTVKAKVT TAMELITPIS AGDLLSPDSV LSCLYPGDHG KKTPNPANQY 420
QFDKVGILTL SDYVLELGHP YLWVQKLGGL HFPKEQPQQT VIADHSLSAS HMETTMKLLK 480
TRVQSRLALH KQFASLEHGI VPVTSDCQYL FPAKVVSRLV KWVTVAHEDY MELHFTKDIV 540
DAGLAGDTNL YYMALIERGT AKLQAAVVLN PGYSSIPPVF QLCLNWKGEK TNSNDDNIRA 600
MEGEVNVCYK ELCGPWPSHQ LLTNQLQRLC VLLDVYLETE SHDDSVEGPK EFPQEKMCLR 660
LFRGPSRMKP FKYNHPQGFF SHR 684

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationChronic myelogenous leukemia/Chronic myeloid leukemiaUY22523032722
[Reference]: We show that THOC5 phosphorylation is elevated in stem cells from patients with chronic myeloid leukemia (CML) and that this phosphorylation is sensitive to the frontline drugs used in CML treatment.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 6)		rs2283859; Vaspin levels; obesity|type 2 diabetes mellitus
rs2283859; Treatment outcomes for selective serotonin reuptake inhibitors (SSRIs) - response at 8 weeks; major depressive disorder
rs2283859; Treatment outcomes for selective serotonin reuptake inhibitors (SSRIs) - response at last visit; major depressive disorder
rs8135828; Lipid traits; lipid metabolism disorder|cardiovascular system disease|obesity
rs5763305; Lipid traits; lipid metabolism disorder|cardiovascular system disease|obesity
rs737980; Esophageal cancer (squamous cell); esophageal cancer

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 19)
(view all)		 16        RKPKVIRSDGAPAEG     dbPAF
2         ******MSSESSKKR     dbPAF
210       EKYRECLSNKEKILK     dbPAF
225       EIEVKKEYLSSLQPR     dbPAF
28        AEGKRNRSDTEQEGK     dbPAF
293       LSVAIEGSVDEAKAL     dbPAF
Acetylation
(count: 8)
(view all)		 204       QRKRLAEKYRECLSN     PLMD
212       YRECLSNKEKILKEI     PLMD
217       SNKEKILKEIEVKKE     PLMD
24        DGAPAEGKRNRSDTE     PLMD
477       SHMETTMKLLKTRVQ     PLMD
491       QSRLALHKQFASLEH     PLMD
Ubiquitination
(count: 6)		 217       SNKEKILKEIEVKKE     PLMD
222       ILKEIEVKKEYLSSL     PLMD
223       LKEIEVKKEYLSSLQ     PLMD
256       MPFDQAHKQYETARH     PLMD
610       GEVNVCYKELCGPWP     PLMD
73        MAEIQDLKSRGGKDV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource