| Tag | Content |
|---|---|
| UniProt Accession | RIPK1_HUMAN; Q13546; |
| Entrez ID | 8737 |
| GenBank Protein ID | NM_003804.4; XM_005249457.3; |
| GenBank Nucleotide ID | NP_003795.2; XP_005249514.2; |
| Protein Name | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP) |
| Gene Name | RIPK1; RIP; RIP1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. |
| Sequence (Fasta) | MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG PNCIEHNEAL 60 LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL MHVLKAEMST PLSVKGRIIL 120 EIIEGMCYLH GKGVIHKDLK PENILVDNDF HIKIADLGLA SFKMWSKLNN EEHNELREVD 180 GTAKKNGGTL YYMAPEHLND VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC 240 IKSGNRPDVD DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED 300 VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG MGPVEESWFA 360 PSLEHPQEEN EPSLQSKLQD EANYHLYGSR MDRQTKQQPR QNVAYNREEE RRRRVSHDPF 420 AQQRPYENFQ NTEGKGTAYS SAASHGNAVH QPSGLTSQPQ VLYQNNGLYS SHGFGTRPLD 480 PGTAGPRVWY RPIPSHMPSL HNIPVPETNY LGNTPTMPFS SLPPTDESIK YTIYNSTGIQ 540 IGAYNYMEIG GTSSSLLDST NTNFKEEPAA KYQAIFDNTT SLTDKHLDPI RENLGKHWKN 600 CARKLGFTQS QIDEIDHDYE RDGLKEKVYQ MLQKWVMREG IKGATVGKLA QALHQCSRID 660 LLSSLIYVSQ N 672 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 9) (view all) | rs2272990; Preschool internalizing problems; Null
rs6907943; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease rs7745598; Coronary artery calcification; coronary artery disease rs17548259; Coronary artery calcification; coronary artery disease rs17513478; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs17513478; LDL cholesterol; atherosclerosis|coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 28) (view all) | 14 LNVIKMKSSDFLESA dbPAF
15 NVIKMKSSDFLESAE dbPAF 161 IADLGLASFKMWSKL dbPAF 166 LASFKMWSKLNNEEH dbPAF 20 KSSDFLESAELDSGG dbPAF 25 LESAELDSGGFGKVS dbPAF |
| Acetylation (count: 3) | 316 SNENAVVKRMQSLQL PLMD
530 PPTDESIKYTIYNST PLMD 604 HWKNCARKLGFTQSQ PLMD |
| Ubiquitination (count: 9) (view all) | 11 DMSLNVIKMKSSDFL PLMD
13 SLNVIKMKSSDFLES PLMD 140 GVIHKDLKPENILVD PLMD 167 ASFKMWSKLNNEEHN PLMD 185 EVDGTAKKNGGTLYY PLMD 316 SNENAVVKRMQSLQL PLMD |
| Malonylation (count: 1) | 604 HWKNCARKLGFTQSQ PLMD |