Q13501

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SQSTM_HUMAN; Q13501;
Entrez ID 8878
GenBank Protein ID NM_001142298.1; NM_001142299.1; NM_003900.4; XM_017010010.1;
GenBank Nucleotide ID NP_001135770.1; NP_001135771.1; NP_003891.1; XP_016865499.1;
Protein Name Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene Name SQSTM1; ORCA; OSIL
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionAutophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha,(view all)
Sequence
(Fasta)		MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP 60
GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN 120
MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS 180
HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV 240
GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV 300
EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE 360
SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK 420
NYDIGAALDT IQYSKHPPPL 441

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationProstate cancer/carcinoma/adenocarcinomaUT26926279575
[Reference]: Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.
2Serine PhosphorylationProstate cancer/carcinoma/adenocarcinomacell lineUS27226279575
[Reference]: Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.
3Serine PhosphorylationAlzheimer's diseaseUS34924886973
[Reference]: Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)		MESH:D000690 ; Amyotrophic Lateral Sclerosis
MESH:C536816 ; Distal myopathy, Nonaka type
OMIM:616437 ; FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 3
MESH:D008268 ; Macular Degeneration
OMIM:617145 ; NEURODEGENERATION WITH ATAXIA, DYSTONIA, AND GAZE PALSY, CHILDHOOD-ONSET
MESH:D010001 ; Osteitis Deformans
GWASdb
(count: 4)		rs72807343; Alzheimer's disease (late onset); Alzheimer's disease
rs7711505; Acute lung injury; lung disease
rs3734007; Multiple complex diseases; Null
rs2450484; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 54)
(view all)		 148       KCSVCPDYDLCSVCE     dbPAF
152       CPDYDLCSVCEGKGL     dbPAF
170       HTKLAFPSPFGHLSE     dbPAF
176       PSPFGHLSEGFSHSR     dbPAF
180       GHLSEGFSHSRWLRK     dbPAF
182       LSEGFSHSRWLRKVK     dbPAF
Acetylation
(count: 5)		 13        VKAYLLGKEDAAREI     PLMD
141       PVVGTRYKCSVCPDY     PLMD
157       LCSVCEGKGLHRGHT     PLMD
295       SCCSDPSKPGGNVEG     PLMD
435       LDTIQYSKHPPPL**     PLMD
Ubiquitination
(count: 12)
(view all)		 13        VKAYLLGKEDAAREI     PLMD
141       PVVGTRYKCSVCPDY     PLMD
157       LCSVCEGKGLHRGHT     PLMD
165       GLHRGHTKLAFPSPF     PLMD
189       SRWLRKVKHGHFGWP     PLMD
264       IDVEHGGKRSRLTPV     PLMD
Sumoylation
(count: 1)		 435       LDTIQYSKHPPPL**     PLMD
Malonylation
(count: 2)		 13        VKAYLLGKEDAAREI     PLMD
141       PVVGTRYKCSVCPDY     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource