| Tag | Content |
|---|---|
| UniProt Accession | GAB1_HUMAN; Q13480; |
| Entrez ID | 2549 |
| GenBank Protein ID | NM_002039.3; NM_207123.2; |
| GenBank Nucleotide ID | NP_002030.2; NP_997006.1; |
| Protein Name | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) |
| Gene Name | GAB1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). |
| Sequence (Fasta) | MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 60 DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEEMNKWVRC ICDICGFNPT 120 EEDPVKPPGS SLQAPADLPL AINTAPPSTQ ADSSSATLPP PYQLINVPPH LETLGIQEDP 180 QDYLLLINCQ SKKPEPTRTH ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM 240 IYDSPPSRAP SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM 300 RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP AHDRSPVETC 360 SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA SSQDCYDIPR AFPSDRSSSL 420 EGFHNHFKVK NVLTVGSVSS EELDENYVPM NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF 480 DFSSFGMQVP PPAHMGFRSS PKTPPRRPVP VADCEPPPVD RNLKPDRKVK PAPLEIKPLP 540 EWEELQAPVR SPITRSFARD SSRFPMSPRP DSVHSTTSSS DSHDSEENYV PMNPNLSSED 600 PNLFGSNSLD GGSSPMIKPK GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS SVADERVDYV 660 VVDQQKTLAL KSTREAWTDG RQSTESETPA KSVK 695 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D011085 ; Polycystic Ovary Syndrome |
| DisGeNet (Curated) (count: 1) | C0032460; Polycystic Ovary Syndrome |
| GWASdb (count: 19) (view all) | rs300917; Multiple complex diseases; Null
rs300916; Multiple complex diseases; Null rs300916; Asthma; asthma rs300915; Multiple complex diseases; Null rs300915; Urate levels; gout rs300913; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 72) (view all) | 183 IQEDPQDYLLLINCQ dbPAF
206 THADSAKSTSSETDC dbPAF 208 ADSAKSTSSETDCND dbPAF 209 DSAKSTSSETDCNDN dbPAF 211 AKSTSSETDCNDNVP dbPAF 242 FFQQQMIYDSPPSRA dbPAF |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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