Tag | Content |
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UniProt Accession | ORC2_HUMAN; Q13416; |
Entrez ID | 4999 |
GenBank Protein ID | NM_006190.4; XM_006712555.3; |
GenBank Nucleotide ID | NP_006181.1; XP_006712618.1; |
Protein Name | Origin recognition complex subunit 2 |
Gene Name | ORC2; ORC2L |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. |
Sequence (Fasta) | MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED 60 DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS 120 VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE 180 SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV 240 EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK 300 WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL 360 DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL 420 IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV 480 LRSLTPNARG IFRLLIKYQL DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR 540 DHKLIRTKKG TDGVEYLLIP VDNGTLTDFL EKEEEEA 578 |
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Database | Annotation |
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GWASdb (count: 1) | rs1912331; Multiple complex diseases; Null |
PTM | Modification Sites |
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Phosphorylation (count: 36) (view all) | 103 SFQNRKHSEKMAKLA dbPAF
111 EKMAKLASELAKTPQ dbPAF 116 LASELAKTPQKSVSF dbPAF 122 KTPQKSVSFSLKNDP dbPAF 124 PQKSVSFSLKNDPEI dbPAF 138 ITINVPQSSKGHSAS dbPAF |
Acetylation (count: 7) (view all) | 108 KHSEKMAKLASELAK PLMD
119 ELAKTPQKSVSFSLK PLMD 147 KGHSASDKVQPKNND PLMD 266 LQKLKRAKLDQQTLR PLMD 278 TLRNLLSKVSPSFSA PLMD 47 AQLLVNPKKIIKKPE PLMD |
Ubiquitination (count: 1) | 278 TLRNLLSKVSPSFSA PLMD |
Sumoylation (count: 2) | 126 KSVSFSLKNDPEITI PLMD
7 *MSKPELKEDKMLEV PLMD |
Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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