Q13416

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ORC2_HUMAN; Q13416;
Entrez ID 4999
GenBank Protein ID NM_006190.4; XM_006712555.3;
GenBank Nucleotide ID NP_006181.1; XP_006712618.1;
Protein Name Origin recognition complex subunit 2
Gene Name ORC2; ORC2L
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionComponent of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
Sequence
(Fasta)
MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED 60
DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS 120
VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE 180
SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV 240
EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK 300
WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL 360
DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL 420
IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV 480
LRSLTPNARG IFRLLIKYQL DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR 540
DHKLIRTKKG TDGVEYLLIP VDNGTLTDFL EKEEEEA 578

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationPancreatic cancer/carcinoma/adenocarcinomaP23188630
[Reference]: Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)
rs1912331; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 36)
(view all)
103       SFQNRKHSEKMAKLA     dbPAF
111       EKMAKLASELAKTPQ     dbPAF
116       LASELAKTPQKSVSF     dbPAF
122       KTPQKSVSFSLKNDP     dbPAF
124       PQKSVSFSLKNDPEI     dbPAF
138       ITINVPQSSKGHSAS     dbPAF
Acetylation
(count: 7)
(view all)
108       KHSEKMAKLASELAK     PLMD
119       ELAKTPQKSVSFSLK     PLMD
147       KGHSASDKVQPKNND     PLMD
266       LQKLKRAKLDQQTLR     PLMD
278       TLRNLLSKVSPSFSA     PLMD
47        AQLLVNPKKIIKKPE     PLMD
Ubiquitination
(count: 1)
278       TLRNLLSKVSPSFSA     PLMD
Sumoylation
(count: 2)
126       KSVSFSLKNDPEITI     PLMD
7         *MSKPELKEDKMLEV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource