Q13283

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession G3BP1_HUMAN; Q13283;
Entrez ID 10146
GenBank Protein ID NM_005754.2; NM_198395.1; XM_006714749.3; XM_006714750.3; XM_017008922.1; XM_017008923.1;
GenBank Nucleotide ID NP_005745.1; NP_938405.1; XP_006714812.1; XP_006714813.1; XP_016864411.1; XP_016864412.1;
Protein Name Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
Gene Name G3BP1; G3BP
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.
Sequence
(Fasta)
MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK PADAVYGQKE 60
IHRKVMSQNF TNCHTKIRHV DAHATLNDGV VVQVMGLLSN NNQALRRFMQ TFVLAPEGSV 120
ANKFYVHNDI FRYQDEVFGG FVTEPQEESE EEVEEPEERQ QTPEVVPDDS GTFYDQAVVS 180
NDMEEHLEEP VAEPEPDPEP EPEQEPVSEI QEEKPEPVLE ETAPEDAQKS SSPAPADIAQ 240
TVQEDLRTFS WASVTSKNLP PSGAVPVTGI PPHVVKVPAS QPRPESKPES QIPPQRPQRD 300
QRVREQRINI PPQRGPRPIR EAGEQGDIEP RRMVRHPDSH QLFIGNLPHE VDKSELKDFF 360
QSYGNVVELR INSGGKLPNF GFVVFDDSEP VQKVLSNRPI MFRGEVRLNV EEKKTRAARE 420
GDRRDNRLRG PGGPRGGLGG GMRGPPRGGM VQKPGFGVGR GLAPRQ 467

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationBreast cancer/tumor/carcinomaU11888885
[Reference]: In addition, HRG stimulation of breast cancer cells promoted phosphorylation of G3BP and increased the association of G3BP with GTPase-activating protein, both of which are essential for G3BP activity.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)
rs1062177; Preschool internalizing problems; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 28)
(view all)
119       FVLAPEGSVANKFYV     dbPAF
125       GSVANKFYVHNDIFR     dbPAF
133       VHNDIFRYQDEVFGG     dbPAF
143       EVFGGFVTEPQEESE     dbPAF
149       VTEPQEESEEEVEEP     dbPAF
162       EPEERQQTPEVVPDD     dbPAF
Acetylation
(count: 10)
(view all)
123       PEGSVANKFYVHNDI     PLMD
257       SWASVTSKNLPPSGA     PLMD
287       SQPRPESKPESQIPP     PLMD
353       NLPHEVDKSELKDFF     PLMD
36        MLHRFYGKNSSYVHG     PLMD
376       LRINSGGKLPNFGFV     PLMD
Ubiquitination
(count: 14)
(view all)
123       PEGSVANKFYVHNDI     PLMD
257       SWASVTSKNLPPSGA     PLMD
353       NLPHEVDKSELKDFF     PLMD
357       EVDKSELKDFFQSYG     PLMD
36        MLHRFYGKNSSYVHG     PLMD
376       LRINSGGKLPNFGFV     PLMD
Sumoylation
(count: 1)
214       VSEIQEEKPEPVLEE     PLMD
Malonylation
(count: 2)
5         ***MVMEKPSPLLVG     PLMD
76        NFTNCHTKIRHVDAH     PLMD
Methylation
(count: 1)
5         ***MVMEKPSPLLVG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
H7C0V6Q13283IntAct
O14929Q13283IntAct
O15264Q13283IntAct
O15530Q13283IntAct
O60674Q13283MINT
O75369Q13283IntAct
O75385Q13283IntAct
O95166Q13283IntAct
P03372Q13283IntAct
P06239Q13283MINT
P06241Q13283MINT
P20936Q13283HPRD
P21333Q13283IntAct
P26196Q13283IntAct
P29322Q13283IntAct
P35658Q13283IntAct
P37198Q13283IntAct
P41240Q13283HPRD; MINT
P49407Q13283IntAct
P54105Q13283IntAct
P60520Q13283IntAct
Q08881Q13283MINT
Q12894Q13283IntAct
Q13131Q13283IntAct
Q13283Q13283HPRD
Q13283Q13823IntAct
Q13283Q14164IntAct
Q13283Q14694HPRD; IntAct
Q13283Q32Q12IntAct
Q13283Q5SRE5IntAct
Q13283Q6FI13IntAct
Q13283Q7KZF4MINT
Q13283Q7Z417IntAct
Q13283Q86Y01IntAct
Q13283Q8IX18IntAct
Q13283Q8IXW5IntAct
Q13283Q8N3C0IntAct
Q13283Q8N9T8IntAct
Q13283Q8NI36IntAct
Q13283Q8WWM7IntAct
Q13283Q96EY4IntAct
Q13283Q96RL1IntAct
Q13283Q9BRJ2IntAct
Q13283Q9BYJ9IntAct
Q13283Q9H0R8IntAct
Q13283Q9H6R4IntAct
Q13283Q9UBN7IntAct
Q13283Q9UHX1IntAct
Q13283Q9UNN5IntAct
Q13283Q9Y4K3IntAct
Q13283Q9Y5J1IntAct