Tag | Content |
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UniProt Accession | G3BP1_HUMAN; Q13283; |
Entrez ID | 10146 |
GenBank Protein ID | NM_005754.2; NM_198395.1; XM_006714749.3; XM_006714750.3; XM_017008922.1; XM_017008923.1; |
GenBank Nucleotide ID | NP_005745.1; NP_938405.1; XP_006714812.1; XP_006714813.1; XP_016864411.1; XP_016864412.1; |
Protein Name | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) |
Gene Name | G3BP1; G3BP |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. |
Sequence (Fasta) | MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK PADAVYGQKE 60 IHRKVMSQNF TNCHTKIRHV DAHATLNDGV VVQVMGLLSN NNQALRRFMQ TFVLAPEGSV 120 ANKFYVHNDI FRYQDEVFGG FVTEPQEESE EEVEEPEERQ QTPEVVPDDS GTFYDQAVVS 180 NDMEEHLEEP VAEPEPDPEP EPEQEPVSEI QEEKPEPVLE ETAPEDAQKS SSPAPADIAQ 240 TVQEDLRTFS WASVTSKNLP PSGAVPVTGI PPHVVKVPAS QPRPESKPES QIPPQRPQRD 300 QRVREQRINI PPQRGPRPIR EAGEQGDIEP RRMVRHPDSH QLFIGNLPHE VDKSELKDFF 360 QSYGNVVELR INSGGKLPNF GFVVFDDSEP VQKVLSNRPI MFRGEVRLNV EEKKTRAARE 420 GDRRDNRLRG PGGPRGGLGG GMRGPPRGGM VQKPGFGVGR GLAPRQ 467 |
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Database | Annotation |
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GWASdb (count: 1) | rs1062177; Preschool internalizing problems; Null |
PTM | Modification Sites |
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Phosphorylation (count: 28) (view all) | 119 FVLAPEGSVANKFYV dbPAF
125 GSVANKFYVHNDIFR dbPAF 133 VHNDIFRYQDEVFGG dbPAF 143 EVFGGFVTEPQEESE dbPAF 149 VTEPQEESEEEVEEP dbPAF 162 EPEERQQTPEVVPDD dbPAF |
Acetylation (count: 10) (view all) | 123 PEGSVANKFYVHNDI PLMD
257 SWASVTSKNLPPSGA PLMD 287 SQPRPESKPESQIPP PLMD 353 NLPHEVDKSELKDFF PLMD 36 MLHRFYGKNSSYVHG PLMD 376 LRINSGGKLPNFGFV PLMD |
Ubiquitination (count: 14) (view all) | 123 PEGSVANKFYVHNDI PLMD
257 SWASVTSKNLPPSGA PLMD 353 NLPHEVDKSELKDFF PLMD 357 EVDKSELKDFFQSYG PLMD 36 MLHRFYGKNSSYVHG PLMD 376 LRINSGGKLPNFGFV PLMD |
Sumoylation (count: 1) | 214 VSEIQEEKPEPVLEE PLMD |
Malonylation (count: 2) | 5 ***MVMEKPSPLLVG PLMD
76 NFTNCHTKIRHVDAH PLMD |
Methylation (count: 1) | 5 ***MVMEKPSPLLVG PLMD |
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