Q13188

※ Protein Information

Tag	Content
UniProt Accession	STK3_HUMAN; Q13188;
Entrez ID	6788
GenBank Protein ID	NM_001256312.1; NM_006281.3;
GenBank Nucleotide ID	NP_001243241.1; NP_006272.2;
Protein Name	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-prot
Gene Name	STK3; KRS1; MST2
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory p(view all) Functional Description Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
Sequence (Fasta)	MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV 60 ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLIE 120 DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT 180 VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT 240 FRKPELWSDD FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK 300 RHEEQQRELE EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES 360 DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM 420 SKNVFPDNWK VPQDGDFDFL KNLSLEELQM RLKALDPMME REIEELRQRY TAKRQPILDA 480 MDAKKRRQQN F 492 Fasta Sequence >Q13188\|STK3; KRS1; MST2\|Homo sapiens (Human) MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Threonine Phosphorylation	Breast cancer/tumor/carcinoma	MCF-7 cell line	U	T117	20231902
1	[Reference]: Further, inverse correlation between pMST2-T117/pAkt and pMST2-T180 was observed in human breast tumors.

※ Disease Cross-ref Annotation

Database	Annotation
GWASdb (count: 34) (view all)	rs12542022; Smoking initiation; nicotine dependence rs4370499; Smoking initiation; nicotine dependence rs12056323; Smoking initiation; nicotine dependence rs16897061; Smoking initiation; nicotine dependence rs12547922; Smoking initiation; nicotine dependence rs10955181; Smoking initiation; nicotine dependence rs3802198; Smoking initiation; nicotine dependence rs6991043; Smoking initiation; nicotine dependence rs7011216; Height; Null rs7011216; Creatinine levels; chronic kidney failure rs12542758; Smoking initiation; nicotine dependence rs12542069; Smoking initiation; nicotine dependence rs6651182; Smoking initiation; nicotine dependence rs4735568; Smoking initiation; nicotine dependence rs12550012; Smoking initiation; nicotine dependence rs12550783; Smoking initiation; nicotine dependence rs10755896; Smoking initiation; nicotine dependence rs10755897; Smoking initiation; nicotine dependence rs12549803; Smoking initiation; nicotine dependence rs12675964; Smoking initiation; nicotine dependence rs11774463; Smoking initiation; nicotine dependence rs12547297; Smoking initiation; nicotine dependence rs12680195; Smoking initiation; nicotine dependence rs11780500; Hearing function; auditory system disease rs11778767; Hearing function; auditory system disease rs34366206; Smoking initiation; nicotine dependence rs10447977; Smoking initiation; nicotine dependence rs12679734; Smoking initiation; nicotine dependence rs4255105; Smoking initiation; nicotine dependence rs2515218; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs2922074; Smoking initiation; nicotine dependence rs2922078; Hearing function; auditory system disease rs3019290; Smoking initiation; nicotine dependence rs2922066; Smoking initiation; nicotine dependence

Database

Annotation

GWASdb
(count: 34)
(view all)

rs12542022; Smoking initiation; nicotine dependence
rs4370499; Smoking initiation; nicotine dependence
rs12056323; Smoking initiation; nicotine dependence
rs16897061; Smoking initiation; nicotine dependence
rs12547922; Smoking initiation; nicotine dependence
rs10955181; Smoking initiation; nicotine dependence

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 18) (view all)	117 IIRLRNKTLIEDEIA dbPAF 15 KSKLKKLSEDSLTKQ dbPAF 174 VAGQLTDTMAKRNTV dbPAF 18 LKKLSEDSLTKQPEE dbPAF 180 DTMAKRNTVIGTPFW dbPAF 316 LEEEEENSDEDELDS dbPAF 323 SDEDELDSHTMVKTS dbPAF 325 EDELDSHTMVKTSVE dbPAF 333 MVKTSVESVGTMRAT dbPAF 336 TSVESVGTMRATSTM dbPAF 384 GTMKRNATSPQVQRP dbPAF 385 TMKRNATSPQVQRPS dbPAF 392 SPQVQRPSFMDYFDK dbPAF 396 QRPSFMDYFDKQDFK dbPAF 406 KQDFKNKSHENCNQN dbPAF 444 FDFLKNLSLEELQMR dbPAF 72 QEIIKEISIMQQCDS dbPAF 81 MQQCDSPYVVKYYGS dbPAF
Acetylation (count: 1)	43 GSYGSVFKAIHKESG PLMD
Ubiquitination (count: 8) (view all)	116 DIIRLRNKTLIEDEI PLMD 21 LSEDSLTKQPEEVFD PLMD 243 NPPPTFRKPELWSDD PLMD 256 DDFTDFVKKCLVKNP PLMD 298 ITEAMEIKAKRHEEQ PLMD 453 EELQMRLKALDPMME PLMD 484 ILDAMDAKKRRQQNF PLMD 56 SGQVVAIKQVPVESD PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

P04049	Q13188	HPRD
P53350	Q13188	IntAct
Q13188	Q9HB71	IntAct
Q13188	Q9NRM7	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction