Tag | Content |
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UniProt Accession | PAK2_HUMAN; Q13177; |
Entrez ID | 5062 |
GenBank Protein ID | NM_002577.4; XM_011512870.2; XM_017006501.1; |
GenBank Nucleotide ID | NP_002568.2; XP_011511172.1; XP_016861990.1; |
Protein Name | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] |
Gene Name | PAK2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream t(view all) |
Sequence (Fasta) | MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT 60 EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP 120 QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP 180 PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV 240 SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE 300 LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH 360 ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY 420 GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC 480 LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR 525 |
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Database | Annotation |
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CTD (Curated) (count: 2) | MESH:D011507
; Proteinuria MESH:D012559 ; Schizophrenia |
GWASdb (count: 4) | rs1684470; Personality dimensions; personality disorder
rs1798619; Personality dimensions; personality disorder rs2084385; Total ventricular volume; Alzheimer's disease rs6789365; Prostate cancer (early onset); prostate cancer |
PTM | Modification Sites |
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Phosphorylation (count: 39) (view all) | 112 LLQTSNITKLEQKKN dbPAF
130 VLDVLKFYDSNTVKQ dbPAF 132 DVLKFYDSNTVKQKY dbPAF 134 LKFYDSNTVKQKYLS dbPAF 139 SNTVKQKYLSFTPPE dbPAF 141 TVKQKYLSFTPPEKD dbPAF |
Acetylation (count: 12) (view all) | 128 QAVLDVLKFYDSNTV PLMD
147 LSFTPPEKDGFPSGT PLMD 191 APRPDHTKSIYTRSV PLMD 216 SHVDGAAKSLDKQKK PLMD 226 DKQKKKTKMTDEEIM PLMD 235 TDEEIMEKLRTIVSI PLMD |
Ubiquitination (count: 19) (view all) | 10 DNGELEDKPPAPPVR PLMD
128 QAVLDVLKFYDSNTV PLMD 136 FYDSNTVKQKYLSFT PLMD 138 DSNTVKQKYLSFTPP PLMD 147 LSFTPPEKDGFPSGT PLMD 226 DKQKKKTKMTDEEIM PLMD |
Malonylation (count: 1) | 52 EEKKPRHKIISIFSG PLMD |
Network | Interaction | ||
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A | B | Source | |