Q13163

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MP2K5_HUMAN; Q13163;
Entrez ID 5607
GenBank Protein ID NM_001206804.1; NM_002757.3; NM_145160.2;
GenBank Nucleotide ID NP_001193733.1; NP_002748.1; NP_660143.1;
Protein Name Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene Name MAP2K5; MEK5; MKK5; PRKMK5
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionActs as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Sequence
(Fasta)		MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120
KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV 180
YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240
TEFMDGGSLD VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 300
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360
KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 420
QFNDGNAAVV SMWVCRALEE RRSQQGPP 449

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationColon cancer/carcinomatumor tissueUS31122458985
[Reference]: pMEK5 expression was significantly higher in CRC tissues (185 out of 335, 55.2%) than in normal tissues (6 out of 80, 7.5%; P < 0.001)
2Threonine PhosphorylationColon cancer/carcinomatumor tissueUT31522458985
[Reference]: pMEK5 expression was significantly higher in CRC tissues (185 out of 335, 55.2%) than in normal tissues (6 out of 80, 7.5%; P < 0.001)

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D019969 ; Amphetamine-Related Disorders
MESH:D001835 ; Body Weight
GWASdb
(count: 23)
(view all)		rs2414975; Multiple complex diseases; Null
rs2414976; Multiple complex diseases; Null
rs8042567; Response to cytidine analogues (gemcitabine); cancer
rs72751410; Menopause (age at onset); obesity|type 2 diabetes mellitus|cardiovascular system disease|osteoporosis|breast cancer|Alzheimer's disease
rs997295; Body mass index (males); obesity
rs997295; Body mass index; obesity

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 129       VNTRAGPSQHSSPAV     dbPAF
132       RAGPSQHSSPAVSDS     dbPAF
133       AGPSQHSSPAVSDSL     dbPAF
137       QHSSPAVSDSLPSNS     dbPAF
142       AVSDSLPSNSLKKSS     dbPAF
144       SDSLPSNSLKKSSAE     dbPAF
Ubiquitination
(count: 4)		 121       ERNIHGLKVNTRAGP     PLMD
146       SLPSNSLKKSSAELK     PLMD
154       KSSAELKKILANGQM     PLMD
298       VNTRGQVKLCDFGVS     PLMD
Glycation
(count: 1)		 146       SLPSNSLKKSSAELK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource