Tag | Content |
---|---|
UniProt Accession | PAK1_HUMAN; Q13153; |
Entrez ID | 5058 |
GenBank Protein ID | NM_001128620.1; NM_002576.4; XM_011545080.2; XM_011545081.2; XM_011545082.2; XM_011545083.2; XM_011545084.2; XM_017017846.1; XM_017017847.1; XM_017017848.1; XM_017017849.1; XM_017017850.1; |
GenBank Nucleotide ID | NP_001122092.1; NP_002567.3; XP_011543382.1; XP_011543383.1; XP_011543384.1; XP_011543385.1; XP_011543386.1; XP_016873335.1; XP_016873336.1; XP_016873337.1; XP_016873338.1; XP_016873339.1; |
Protein Name | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) |
Gene Name | PAK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby me(view all) |
Sequence (Fasta) | MSNNGLDIQD KPPAPPMRNT STMIGAGSKD AGTLNHGSKP LPPNPEEKKK KDRFYRSILP 60 GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN 120 PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNALN VKAVSETPAV PPVSEDEDDD 180 DDDATPPPVI APRPEHTKSV YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE 240 KQKKKPKMSD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAMDV ATGQEVAIKQ 300 MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG SLTDVVTETC 360 MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD GSVKLTDFGF CAQITPEQSK 420 RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL GIMAIEMIEG EPPYLNENPL RALYLIATNG 480 TPELQNPEKL SAIFRDFLNR CLEMDVEKRG SAKELLQHQF LKIAKPLSSL TPLIAAAKEA 540 TKNNH 546 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 3) | MESH:D001943
; Breast Neoplasms MESH:D002292 ; Carcinoma, Renal Cell MESH:D011507 ; Proteinuria |
GWASdb (count: 7) (view all) | rs1377470; Parkinson's disease; Parkinson's disease
rs1453342; Vascular dementia; vascular dementia rs2602475; Pure-tone audiometry; auditory system disease rs618012; Smoking cessation; nicotine dependence rs10501425; Pure-tone audiometry; auditory system disease rs527589; Orofacial clefts; orofacial cleft |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 44) (view all) | 109 QWARLLQTSNITKSE dbPAF
110 WARLLQTSNITKSEQ dbPAF 115 QTSNITKSEQKKNPQ dbPAF 131 VLDVLEFYNSKKTSN dbPAF 133 DVLEFYNSKKTSNSQ dbPAF 136 EFYNSKKTSNSQKYM dbPAF |
Acetylation (count: 3) | 256 SDEEILEKLRSIVSV PLMD
29 TMIGAGSKDAGTLNH PLMD 63 RSILPGDKTNKKKEK PLMD |
Ubiquitination (count: 2) | 247 EKQKKKPKMSDEEIL PLMD
508 CLEMDVEKRGSAKEL PLMD |
Sumoylation (count: 1) | 256 SDEEILEKLRSIVSV PLMD |
Glycation (count: 1) | 299 TGQEVAIKQMNLQQQ PLMD |
Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|