Tag | Content |
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UniProt Accession | AAPK1_HUMAN; Q13131; |
Entrez ID | 5562 |
GenBank Protein ID | NM_006251.5; NM_206907.3; |
GenBank Nucleotide ID | NP_006242.5; NP_996790.3; |
Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRK |
Gene Name | PRKAA1; AMPK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of (view all) |
Sequence (Fasta) | MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 60 QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 120 RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF 180 LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG 240 IFYTPQYLNP SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID 300 DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS 360 FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI 420 MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTYSKMSL QLYQVDSRTY LLDFRSIDDE 480 ITEAKSGTAT PQRSGSVSNY RSCQRSDSDA EAQGKSSEVS LTSSVTSLDS SPVDLTPRPG 540 SHTIEFFEMC ANLIKILAQ |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D018149
; Glucose Intolerance MESH:D007333 ; Insulin Resistance MESH:D013274 ; Stomach Neoplasms |
GWASdb (count: 12) (view all) | rs1002424; Schizophrenia; schizophrenia
rs3792822; Major depressive disorder; major depressive disorder rs10074991; Multiple complex diseases; Null rs10074991; Major depressive disorder; major depressive disorder rs10074991; Autism spectrum disorders (language delay); autism spectrum disorder rs10074991; Parkinson's disease; Parkinson's disease |
PTM | Modification Sites |
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Phosphorylation (count: 41) (view all) | 172 KIADFGLSNMMSDGE dbPAF
183 SDGEFLRTSCGSPNY dbPAF 184 DGEFLRTSCGSPNYA dbPAF 187 FLRTSCGSPNYAAPE dbPAF 247 GIFYTPQYLNPSVIS dbPAF 293 YLFPEDPSYSSTMID dbPAF |
Acetylation (count: 4) | 40 LGVGTFGKVKVGKHE PLMD
429 AEVCRAIKQLDYEWK PLMD 52 KHELTGHKVAVKILN PLMD 71 RSLDVVGKIRREIQN PLMD |
Ubiquitination (count: 13) (view all) | 236 HVPTLFKKICDGIFY PLMD
266 MLQVDPMKRATIKDI PLMD 280 IREHEWFKQDLPKYL PLMD 285 WFKQDLPKYLFPEDP PLMD 349 RRIMNEAKDFYLATS PLMD 396 LDELNPQKSKHQGVR PLMD |
Glycation (count: 1) | 23 QKHDGRVKIGHYILG PLMD |