Q13118

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession KLF10_HUMAN; Q13118;
Entrez ID 7071
GenBank Protein ID NM_001032282.3; NM_005655.3;
GenBank Nucleotide ID NP_001027453.1; NP_005646.1;
Protein Name Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1)
Gene Name KLF10; TIEG; TIEG1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
Sequence
(Fasta)		MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC SWKSDFKKYV 60
ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD FEPSQVSNLM APAPSTVHFK 120
SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA QATSVIRHTA DAQLCNHQTC PMKAASILNY 180
QNNSFRRRTH LNVEAARKNI PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI 240
CRSQPAPVSP QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA 300
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF SPSAAKVTPQ 360
IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS CSWKGCERRF ARSDELSRHR 420
RTHTGEKKFA CPMCDRRFMR SDHLTKHARR HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ 480
481

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PolyubiquitinationProstate cancer/carcinoma/adenocarcinomaTRAMP-C2 cell lineP21471442
[Reference]: Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 16)
(view all)		 184       ILNYQNNSFRRRTHL     dbPAF
206       NIPCAAVSPNRSKCE     dbPAF
249       RSQPAPVSPQQKSVL     dbPAF
335       SSKPPVVSPNGTRLS     dbPAF
339       PVVSPNGTRLSPIAP     dbPAF
351       IAPAPGFSPSAAKVT     dbPAF
Acetylation
(count: 1)		 135       PHIAAPFKEEEKSPV     PLMD
Ubiquitination
(count: 8)
(view all)		 139       APFKEEEKSPVSAPK     PLMD
223       TVADVDEKASAALYD     PLMD
32        ESMYSWNKTAEKSDF     PLMD
330       QPVVQSSKPPVVSPN     PLMD
356       GFSPSAAKVTPQIDS     PLMD
36        SWNKTAEKSDFEAVE     PLMD
Sumoylation
(count: 3)		 135       PHIAAPFKEEEKSPV     PLMD
149       VSAPKLPKAQATSVI     PLMD
456       RRHLSAKKLPNWQME     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource