Q13085

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	ACACA_HUMAN; Q13085;
Entrez ID	31
GenBank Protein ID	NM_198834.2; NM_198836.2; NM_198837.1; NM_198838.1; NM_198839.2; XM_011524703.1; XM_017024555.1;
GenBank Nucleotide ID	NP_942131.1; NP_942133.1; NP_942134.1; NP_942135.1; NP_942136.1; XP_011523005.1; XP_016880044.1;
Protein Name	Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)]
Gene Name	ACACA; ACAC; ACC1; ACCA
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Functional Description Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Sequence (Fasta)	MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVGSDTLS 60 DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK 120 VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG 180 GPNNNNYANV ELILDIAKRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL 240 GDKIASSIVA QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA 300 AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV 360 QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV FEHMEQCAVK LAKMVGYVSA 420 GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY 480 GVSPWGDSPI DFEDSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY 540 FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET 600 ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN FLHSLERGQV 660 LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG 720 SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVMRSPSAG KLIQYIVEDG GHVFAGQCYA 780 EIEVMKMVMT LTAVESGCIH YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ 840 STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSKVKD WVERLMKTLR DPSLPLLELQ 900 DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV 960 FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD 1020 MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR 1080 ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH 1140 SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM 1200 SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFSDSP 1260 PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDRLAAMFRE FTQQNKATLV 1320 DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ 1380 LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE 1440 YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG 1500 SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA 1560 YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSTQA 1620 FLPSPPLPSD MLTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTFKSPE YPEGRDIIVI 1680 GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVSANS GARIGLAEEI RHMFHVAWVD 1740 PEDPYKGYRY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GIGPENLRGS 1800 GMIAGESSLA YNEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR 1860 EVYTSNNQLG GIQIMHNNGV THCTVCDDFE GVFTVLHWLS YMPKSVHSSV PLLNSKDPID 1920 RIIEFVPTKT PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG 1980 IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL 2040 MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECCQPVLV YIPPQAELRG GSWVVIDSSI 2100 NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSTAE 2160 RKELENKLKE REEFLIPIYH QVAVQFADLH DTPGRMQEKG VISDILDWKT SRTFFYWRLR 2220 RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL AEWLEKQLTE 2280 EDGVHSVIEE NIKCISRDYV LKQIRSLVQA NPEVAMDSII HMTQHISPTQ RAEVIRILST 2340 MDSPST 2347 Fasta Sequence >Q13085\|ACACA; ACAC; ACC1; ACCA\|Homo sapiens (Human) MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTEEDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRILSTMDSPST

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Lung cancer/carcinoma		P	S80	22348039
1	[Reference]: The results showed that 18 molecules were significantly different (p<0.05) by at least 30% between normal and tumor tissues.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:C562678 ; Acetyl-Coa Carboxylase Deficiency MESH:D006528 ; Carcinoma, Hepatocellular MESH:D006333 ; Heart Failure
DisGeNet (Curated) (count: 10) (view all)	C0018801; Heart failure C0026827; Muscle hypotonia C0026848; Myopathy C0151686; Growth retardation C0456070; Growth delay C0878787; Growth failure C1837385; Poor growth C2239176; Liver carcinoma C3552463; Very poor growth C4020899; Autosomal recessive predisposition
HGMD (count: 1)	CM044557; Ovarian cancer ?; Missense/nonsense
GWASdb (count: 10) (view all)	rs1266180; Alzheimer's disease; Alzheimer's disease rs1266182; Alzheimer's disease; Alzheimer's disease rs1266175; Alzheimer's disease; Alzheimer's disease rs12450937; Alzheimer's disease; Alzheimer's disease rs7221404; Alzheimer's disease; Alzheimer's disease rs2305098; Urinary metabolites; kidney disease rs2590728; Urinary metabolites; kidney disease rs17841479; Urinary metabolites; kidney disease rs8081319; Celiac disease; celiac disease rs878520; Lymphocyte counts; asthma\|leukemia\|lymphoma\|lymphopenia\|cardiovascular system disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 70) (view all)	104 QRDFTVASPAEFVTR dbPAF 1042 TKKNLLVTMLIDQLC dbPAF 1073 LTQLSKTTNAKVALR dbPAF 1196 PNRGNIPTLNRMSFS dbPAF 1201 IPTLNRMSFSSNLNH dbPAF 1209 FSSNLNHYGMTHVAS dbPAF 1216 YGMTHVASVSDVLLD dbPAF 1218 MTHVASVSDVLLDNS dbPAF 1227 VLLDNSFTPPCQRMG dbPAF 1238 QRMGGMVSFRTFEDF dbPAF 1257 DEVMGCFSDSPPQSP dbPAF 1259 VMGCFSDSPPQSPTF dbPAF 1263 FSDSPPQSPTFPEAG dbPAF 1265 DSPPQSPTFPEAGHT dbPAF 1273 FPEAGHTSLYDEDKV dbPAF 1342 DFRKQVNYEVDRRFH dbPAF 1370 KFEEDRIYRHLEPAL dbPAF 1438 DLVTKEASFEYLQNE dbPAF 1441 TKEASFEYLQNEGER dbPAF 1494 KIEESVRSMVMRYGS dbPAF 1499 VRSMVMRYGSRLWKL dbPAF 1501 SMVMRYGSRLWKLRV dbPAF 17 PLELNQHSRFIIGSV dbPAF 1720 RIYVSANSGARIGLA dbPAF 1745 WVDPEDPYKGYRYLY dbPAF 1844 RTIQVENSHLILTGA dbPAF 1849 ENSHLILTGAGALNK dbPAF 1908 YMPKSVHSSVPLLNS dbPAF 2099 SWVVIDSSINPRHME dbPAF 2108 NPRHMEMYADRESRG dbPAF 2144 MRRVDPVYIHLAERL dbPAF 2153 HLAERLGTPELSTAE dbPAF 23 HSRFIIGSVSEDNSE dbPAF 2327 IHMTQHISPTQRAEV dbPAF 234 IAFMGPPSQAMWALG dbPAF 2343 RILSTMDSPST** dbPAF 25 RFIIGSVSEDNSEDE dbPAF 286 LNVPQELYEKGYVKD dbPAF 29 GSVSEDNSEDEISNL dbPAF 290 QELYEKGYVKDVDDG dbPAF 34 DNSEDEISNLVKLDL dbPAF 344 VQAEVPGSPIFVMRL dbPAF 417 KLAKMVGYVSAGTVE dbPAF 434 YSQDGSFYFLELNPR dbPAF 48 LLEEKEGSLSPASVG dbPAF 488 GVSPWGDSPIDFEDS dbPAF 5 *MDEPSPLAQPLE dbPAF 50 EEKEGSLSPASVGSD dbPAF 53 EGSLSPASVGSDTLS dbPAF 56 LSPASVGSDTLSDLG dbPAF 58 PASVGSDTLSDLGIS dbPAF 60 SVGSDTLSDLGISSL dbPAF 610 FQMNRIDTGWLDRLI dbPAF 66 LSDLGISSLQDGLAL dbPAF 676 TVDVELIYEGVKYVL dbPAF 734 MKEEVDRYRITIGNK dbPAF 752 FEKENDPSVMRSPSA dbPAF 756 NDPSVMRSPSAGKLI dbPAF 77 GLALHIRSSMSGLHL dbPAF 78 LALHIRSSMSGLHLV dbPAF 80 LHIRSSMSGLHLVKQ dbPAF 801 VESGCIHYVKRPGAA dbPAF 835 QAELHTGSLPRIQST dbPAF 841 GSLPRIQSTALRGEK dbPAF 855 KLHRVFHYVLDNLVN dbPAF 867 LVNVMNGYCLPDPFF dbPAF 893 MKTLRDPSLPLLELQ dbPAF 907 QDIMTSVSGRIPPNV dbPAF 96 RDRKKIDSQRDFTVA dbPAF 977 QLVQRYRSGIRGHMK dbPAF
Acetylation (count: 6)	1334 LTFLVAQKDFRKQVN PLMD 1580 INTPYVTKDLLQSKR PLMD 1788 KITDIIGKEEGIGPE PLMD 1856 TGAGALNKVLGREVY PLMD 2127 PEGTVEIKFRRKDLV PLMD 817 DPGCVLAKMQLDNPS PLMD
Ubiquitination (count: 25) (view all)	1316 REFTQQNKATLVDHG PLMD 1334 LTFLVAQKDFRKQVN PLMD 1338 VAQKDFRKQVNYEVD PLMD 1435 RHSDLVTKEASFEYL PLMD 1524 IRLTPTGKAIPIRLF PLMD 1759 YLTPQDYKRVSALNS PLMD 1781 DEGESRYKITDIIGK PLMD 1788 KITDIIGKEEGIGPE PLMD 1856 TGAGALNKVLGREVY PLMD 1916 SVPLLNSKDPIDRII PLMD 1929 IIEFVPTKTPYDPRW PLMD 2031 FKTYQAIKDFNREGL PLMD 2127 PEGTVEIKFRRKDLV PLMD 2209 ISDILDWKTSRTFFY PLMD 2260 VEVEGTVKAYVWDNN PLMD 2293 SVIEENIKCISRDYV PLMD 2302 ISRDYVLKQIRSLVQ PLMD 276 WQENDFSKRILNVPQ PLMD 288 VPQELYEKGYVKDVD PLMD 311 VGYPVMIKASEGGGG PLMD 386 SVQRRHQKIIEEAPA PLMD 410 HMEQCAVKLAKMVGY PLMD 747 NKTCVFEKENDPSVM PLMD 817 DPGCVLAKMQLDNPS PLMD 825 MQLDNPSKVQQAELH PLMD
Malonylation (count: 2)	1334 LTFLVAQKDFRKQVN PLMD 323 GGGKGIRKVNNADDF PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

P09914	Q13085	IntAct
P38398	Q13085	IntAct
P54646	Q13085	HPRD
Q13085	Q96EB6	IntAct