Q13043

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession STK4_HUMAN; Q13043;
Entrez ID 6789
GenBank Protein ID NM_006282.3; XM_005260533.2;
GenBank Nucleotide ID NP_006273.1; XP_005260590.1;
Protein Name Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-prot
Gene Name STK4; KRS2; MST1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionStress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory p(view all)
Sequence
(Fasta)
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ 60
VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT 120
LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK 180
RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP 240
PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV 300
KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT 360
LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK 420
NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK 480
KRRQQNF 488

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationOvarian cancer/carcinomacell linesUT12019940129
[Reference]: Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.
2Threonine PhosphorylationOvarian cancer/carcinomaDT18319940129
[Reference]: Further, inverse correlation between pMST1-Thr(120) and pMST1-Thr(183) was observed in human ovarian tumors.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
OMIM:614868 ; T-CELL IMMUNODEFICIENCY, RECURRENT INFECTIONS, AND AUTOIMMUNITY WITH OR WITHOUT CARDIAC MALFORMATIONS
GWASdb
(count: 7)
(view all)
rs927000; Bipolar disorder and schizophrenia; bipolar disorder|schizophrenia
rs17322289; Neuroblastoma; neuroblastoma
rs2284271; Melanoma; skin melanoma
rs2284271; Metabolite levels; inherited metabolic disorder
rs17420378; Multiple complex diseases; Null
rs2180291; Urinary metabolites; kidney disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 38)
(view all)
120       IIRLRNKTLTEDEIA     dbPAF
122       RLRNKTLTEDEIATI     dbPAF
132       EIATILQSTLKGLEY     dbPAF
175       FGVAGQLTDTMAKRN     dbPAF
177       VAGQLTDTMAKRNTV     dbPAF
183       DTMAKRNTVIGTPFW     dbPAF
Ubiquitination
(count: 11)
(view all)
119       DIIRLRNKTLTEDEI     PLMD
151       RKIHRDIKAGNILLN     PLMD
180       QLTDTMAKRNTVIGT     PLMD
246       NPPPTFRKPELWSDN     PLMD
264       FVKQCLVKSPEQRAT     PLMD
285       HPFVRSAKGVSILRD     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource