Tag | Content |
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UniProt Accession | STK4_HUMAN; Q13043; |
Entrez ID | 6789 |
GenBank Protein ID | NM_006282.3; XM_005260533.2; |
GenBank Nucleotide ID | NP_006273.1; XP_005260590.1; |
Protein Name | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-prot |
Gene Name | STK4; KRS2; MST1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory p(view all) |
Sequence (Fasta) | METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ 60 VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT 120 LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK 180 RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP 240 PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV 300 KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT 360 LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK 420 NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK 480 KRRQQNF 488 |
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Database | Annotation |
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CTD (Curated) (count: 1) | OMIM:614868 ; T-CELL IMMUNODEFICIENCY, RECURRENT INFECTIONS, AND AUTOIMMUNITY WITH OR WITHOUT CARDIAC MALFORMATIONS |
GWASdb (count: 7) (view all) | rs927000; Bipolar disorder and schizophrenia; bipolar disorder|schizophrenia
rs17322289; Neuroblastoma; neuroblastoma rs2284271; Melanoma; skin melanoma rs2284271; Metabolite levels; inherited metabolic disorder rs17420378; Multiple complex diseases; Null rs2180291; Urinary metabolites; kidney disease |
PTM | Modification Sites |
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Phosphorylation (count: 38) (view all) | 120 IIRLRNKTLTEDEIA dbPAF
122 RLRNKTLTEDEIATI dbPAF 132 EIATILQSTLKGLEY dbPAF 175 FGVAGQLTDTMAKRN dbPAF 177 VAGQLTDTMAKRNTV dbPAF 183 DTMAKRNTVIGTPFW dbPAF |
Ubiquitination (count: 11) (view all) | 119 DIIRLRNKTLTEDEI PLMD
151 RKIHRDIKAGNILLN PLMD 180 QLTDTMAKRNTVIGT PLMD 246 NPPPTFRKPELWSDN PLMD 264 FVKQCLVKSPEQRAT PLMD 285 HPFVRSAKGVSILRD PLMD |
Network | Interaction | ||
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A | B | Source | |