| Tag | Content |
|---|---|
| UniProt Accession | TRAF2_HUMAN; Q12933; |
| Entrez ID | 7186 |
| GenBank Protein ID | NM_021138.3; XM_011518974.2; XM_011518975.2; XM_011518976.2; XM_011518977.2; XM_011518978.2; XM_017015095.1; |
| GenBank Nucleotide ID | NP_066961.2; XP_011517276.1; XP_011517277.1; XP_011517278.1; XP_011517279.1; XP_011517280.1; XP_016870584.1; |
| Protein Name | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) |
| Gene Name | TRAF2; TRAP3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. |
| Sequence (Fasta) | MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS 60 ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE 120 YESCHEGRCP LMLTECPACK GLVRLGEKER HLEHECPERS LSCRHCRAPC CGADVKAHHE 180 VCPKFPLTCD GCGKKKIPRE KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL 240 REHLAMLLSS VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA 300 EACSRQHRLD QDKIEALSSK VQQLERSIGL KDLAMADLEQ KVLEMEASTY DGVFIWKISD 360 FARKRQEAVA GRIPAIFSPA FYTSRYGYKM CLRIYLNGDG TGRGTHLSLF FVVMKGPNDA 420 LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD VTSSSFQRPV NDMNIASGCP LFCPVSKMEA 480 KNSYVRDDAI FIKAIVDLTG L 502 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 8) (view all) | rs17243641; LDL cholesterol; atherosclerosis|coronary artery disease
rs17243641; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs17243641; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease rs56079415; Beta-trace protein levels; kidney disease rs4880160; Urinary metabolites; kidney disease rs17250539; Beta-trace protein levels; kidney disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 13) (view all) | 102 AARREVESLPAVCPS dbPAF
11 ASVTPPGSLELLQPG dbPAF 117 DGCTWKGTLKEYESC dbPAF 121 WKGTLKEYESCHEGR dbPAF 20 ELLQPGFSKTLLGTK dbPAF 22 LQPGFSKTLLGTKLE dbPAF |
| Acetylation (count: 1) | 31 LGTKLEAKYLCSACR PLMD |
| Ubiquitination (count: 18) (view all) | 115 PSDGCTWKGTLKEYE PLMD
119 CTWKGTLKEYESCHE PLMD 140 LTECPACKGLVRLGE PLMD 176 PCCGADVKAHHEVCP PLMD 194 LTCDGCGKKKIPREK PLMD 201 KKKIPREKFQDHVKT PLMD |